A5105826957- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Obesity, Physical Activity, Diet
- Blood Pressure and Hypertension Studies
- Obesity and Health Practices
- Cardiovascular Health and Risk Factors
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Education
- Nutritional Studies and Diet
- Chronic Kidney Disease and Diabetes
- Retinal Diseases and Treatments
- Diet, Metabolism, and Disease
- Bariatric Surgery and Outcomes
- Gestational Diabetes Research and Management
- Hormonal Regulation and Hypertension
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Physical Activity and Health
- Ovarian function and disorders
- Chronic Disease Management Strategies
- Platelet Disorders and Treatments
University of Pittsburgh
2016-2025
Charlottesville Medical Research
2019-2024
Children's of Alabama
2024
Lincoln Memorial University
2023
Creative Research Enterprises (United States)
2017
nLIGHT (United States)
2015
United States Department of Veterans Affairs
2015
Veterans Health Administration
2015
Michael & Associates
2013
Foster-Miller (United States)
2012
<h3>Background</h3> Clinical treatment goals of type 1 diabetes mellitus (T1DM) have changed since the Diabetes Control and Complications Trial (DCCT) demonstrated reduced long-term complications with intensive therapy. There been few longitudinal studies to describe clinical course T1DM in age Our objective was current-day T1DM. <h3>Methods</h3> An analysis cumulative incidence performed. The DCCT (1983-1993) assigned patients conventional or Since 1993, has observational, therapy...
Diabet. Med. 27, 398–404 (2010) Abstract Aims Time trends in overweight and obesity the general population have been well documented; however, temporal patterns Type 1 diabetes (T1DM) not thoroughly investigated. We therefore assessed predictors of weight change 589 individuals from Pittsburgh Epidemiology Diabetes Complications Study, a cohort childhood‐onset T1DM. Methods Participants were first seen 1986–1988, when mean age duration 29 20 years, respectively, biennially thereafter for 18...
Survival in type 1 diabetes has improved, but the impact on life expectancy U.S. population is not well established. Our objective was to estimate of Pittsburgh Epidemiology Diabetes Complications (EDC) study cohort and quantify improvements by comparing two subcohorts based year diagnosis (1950-1964 [n = 390] vs. 1965-1980 543]). The EDC a prospective 933 participants with childhood-onset (aged <17 years) diagnosed at Children's Hospital from 1950 1980. Mortality ascertainment censored 31...
Significance Statement Although studies show that diabetic kidney disease has a heritable component, searches for the genetic determinants of this complication diabetes have had limited success. In study, new international genomics consortium, JDRF funded Diabetic Nephropathy Collaborative Research Initiative, assembled nearly 20,000 samples from participants with type 1 diabetes, and without disease. The authors found 16 disease–associated loci at genome-wide significance. strongest signal...
To determine whether safety culture factors varied across the intensive care units (ICUs) of a single hospital, between nurses and physicians, to explore ICU nursing directors' perceptions their personnel's attitudes.Cross-sectional surveys using Safety Attitudes Questionnaire-ICU version, validated, aviation industry-based survey instrument. It assesses six factors: teamwork climate, management, stress recognition, job satisfaction, work environment.Four ICUs in one tertiary hospital.All...
OBJECTIVE The aim of this study was to investigate the presence and correlates clinically relevant cognitive impairment in middle-aged adults with childhood-onset type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS During 2010–2013, 97 diagnosed T1D aged &lt;18 years (age duration 49 ± 7 41 6 years, respectively; 51% female) 138 similarly without years; 55% completed extensive neuropsychological testing. Biomedical data on participants were collected periodically since 1986–1988....
The degree to which mortality and cardiovascular disease (CVD) incidence remains elevated in young U.S. adults with type 1 diabetes (T1DM) is unclear. We determined contemporary rates for <45 years old long-standing, childhood-onset T1DM from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study.Members EDC Study cohort during 1996-2012 follow-up period (n = 502) were studied. Mortality CVD calculated those aged 30-39 40-44 years. Data background Allegheny County, Pennsylvania,...
In a recent Diabetes Control and Complications Trial (DCCT)/Epidemiology of Interventions (EDIC) study report, mean HbA1c was the strongest predictor cardiovascular disease (CVD) after age. DCCT/EDIC, diabetes duration 6 years (median 4) at baseline those with high blood pressure or cholesterol were excluded. We now replicate these analyses in Pittsburgh Epidemiology (EDC) prospective cohort childhood-onset (at &lt;17 age) type 1 diabetes, similar age (mean 27 both studies) but longer 19...
Background The cholesterol efflux capacity of high density lipoprotein (HDL) is negatively associated with cardiovascular risk. Small HDL particles account almost quantitatively for capacity, perhaps mediated through and outer leaflet plasma membrane phospholipids by ABCA1 (ATP binding cassette subfamily A member 1). People type 1 diabetes are at increased coronary artery disease (CAD) risk despite normal HDL‐cholesterol concentrations. We therefore tested the hypothesis that small...
Objective: To determine whether an evidence-based, behavioral lifestyle intervention program delivered at a worksite setting is effective in improving type 2 diabetes and cardiovascular disease risk factors. Methods: A randomized 6-month delayed control design was utilized, with two thirds of the participants assigned to begin immediately, one third beginning 6 months later. The year-long (weekly for 3 transitioning monthly) focused on weight loss increasing physical activity. Results:...