A5044761926- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and genetic disorders
- Cerebrovascular and Carotid Artery Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Functional Brain Connectivity Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Renal and Vascular Pathologies
- Fetal and Pediatric Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Cardiac, Anesthesia and Surgical Outcomes
- MRI in cancer diagnosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Brain Tumor Detection and Classification
- Retinal Imaging and Analysis
- Effects of Vibration on Health
Brigham and Women's Hospital
2014-2024
Harvard University
2014-2024
Beth Israel Deaconess Medical Center
2017-2024
Hebrew SeniorLife
2017-2023
Hadassah Medical Center
2019
Massachusetts General Hospital
2019
State University of New York
2017
Binghamton University
2017
Brown University
2017
Azienda Ospedaliera Sant'Andrea
2006-2015
The kynurenine pathway of tryptophan metabolism has been implicated in the pathophysiology psychiatric disorders, including schizophrenia. We report here that metabolite, xanturenic acid (XA), interacts with, and activates mGlu2 mGlu3 metabotropic glutamate receptors heterologous expression systems. However, molecular nature this interaction is unknown, our data cannot exclude XA acts primarily on other targets, such as vesicular transporter, CNS. Systemic administration mice produced...
Despite the significant impact of postoperative delirium on surgical outcomes and long-term prognosis older patients, its neural basis has not yet been clarified. In this study we investigated premorbid brain microstructural integrity, as measured by diffusion tensor imaging before surgery, incidence severity, well relationship among presurgical cognitive performance, abnormalities delirium. Presurgical scans 136 (≥70 years), dementia-free subjects from prospective Successful Aging after...
Prostate cancer (PC) is a frequent male malignancy and represents the second most diagnosed in men. Since pre-cancerous lesions, i.e., high-grade prostatic intraepithelial neoplasia (HGPIN), can be detected years before progression to PC, early diagnosis chemoprevention are targeted strategies reduce PC rates. Animal studies have shown that lycopene, carotenoid contained tomatoes, promising candidate for of PC. However, its efficacy humans remains controversial. The present study aimed...
It is unclear whether fatigue a consequence or predictive trait of disease worsening.To investigate the value toward conversion to confirmed moderate-severe disability in patients with relapsing-remitting multiple sclerosis (RRMS).We retrospectively selected from Comprehensive Longitudinal Investigations MS at Brigham and Women's Hospital (CLIMB) study cohort RRMS who converted (⩾2 years) Expanded Disability Status Scale (EDSS) score ⩾3 within follow-up period years. We contrasted Modified...
ABSTRACT BACKGROUND AND PURPOSE A pipeline for fully automated segmentation of 3T brain MRI scans in multiple sclerosis (MS) is presented. This morphometry (3TM) provides indicators MS disease progression from multichannel datasets with high‐resolution 3‐dimensional T1‐weighted, T2‐weighted, and fluid‐attenuated inversion‐recovery (FLAIR) contrast. 3TM segments white (WM) gray matter (GM) cerebrospinal fluid (CSF) to assess atrophy WM lesion (WML) volume. METHODS To address nonuniform...
The Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) affects mainly small cerebral arteries leads to disability dementia. relationship between clinical expression of the disease progression microvessel pathology is, however, uncertain as we lack tools for imaging brain vessels in vivo. Ophthalmoscopy is regarded a window into microcirculation. In this study carried out an ophthalmoscopic examination subjects CADASIL. Specifically, performed...
To investigate the effect of postoperative delirium on longitudinal brain microstructural changes, as measured by diffusion tensor imaging.We studied a subset larger Successful Aging after Elective Surgery (SAGES) study cohort older adults (≥70 years) without dementia undergoing elective surgery: 113 participants who had imaging before and 1 year surgery. Postoperative severity occurrence were assessed during hospital stay using Confusion Assessment Method validated chart review method. We...
Morphological analysis of the retinal vessels by fundoscopy provides noninvasive means for detecting and staging systemic microvascular damage. However, full exploitation in clinical settings is limited paucity quantitative, objective information obtainable through observer-driven evaluations currently employed routine practice. Here, we report on development a semiautomated, computer-based method to assess vessel morphology. The allows simultaneous operator-independent quantitative...
Three-dimensional Arterial Spin Labeling (ASL) MRI was performed before surgery in a cohort of 146 prospectively enrolled subjects ≥ 70 years old scheduled to undergo elective surgery. We investigated the prospective association between ASL-derived measures cerebral blood flow (CBF) with postoperative delirium incidence and severity using whole-brain globally normalized voxel-wise analysis. also cross-sectional CBF patients’ baseline performance on specific neuropsychological tests,...
Grey matter (GM) damage is a clinically relevant feature of multiple sclerosis (MS) that has been previously assessed with diffusion tensor imaging (DTI). Fractional anisotropy (FA) the basal ganglia and thalamus might be increased in MS patients, correlates disability scores. Despite established role striatum motor control, mood cognition, impact DTI changes within these structures on neuropsychological performance not yet specifically addressed MS. We investigated metrics deep GM nuclei...
Background: Several magnetic resonance imaging (MRI) studies investigated the evolution of multiple sclerosis (MS) lesions to understand pathophysiological mechanisms leading blood-brain barrier breakdown and lesion formation. Only a few assessed early natural history MS using short-interval longitudinal MRI. Objective: The purpose this study was characterize occurrence on high-resolution MRI acquired at weekly intervals. Methods: Active were characterized 3D fluid attenuation inversion...
Background: Fatigue in multiple sclerosis (MS) has been inconsistently associated with disruption of specific brain circuitries. Temporal fluctuations fatigue have not considered. Objective: The aim this study was to investigate the association diffusion abnormalities, using robust criteria for patient stratification based on longitudinal patterns fatigue. Methods: Patient stratification: (1) sustained (SF, n = 26): latest two Modified Impact Scale (MFIS) ⩾ 38; (2) reversible (RF, 25): MFIS...
Fatigue in multiple sclerosis (MS) has been associated with brain damage low replicability. Temporal fatigue fluctuations have not considered. We assessed whether sustained (SF) associates more strongly grey matter (GM) changes than reversible (RF). Patients were stratified into three groups according to historical levels: SF (n = 30, i.e. patients who reported at the latest ≥2 assessments), RF 31, fatigued assessment, but previously), and never (NF, n 37). Groups compared for GM volume...
Major surgery is associated with a systemic inflammatory cascade that thought, in some cases, to contribute transient and/or sustained cognitive decline, possibly through neuroinflammatory mechanisms. However, the relationship between surgery, peripheral and central nervous system inflammation, post-operative outcomes remains unclear humans, primarily owing limitations of vivo biomarkers neuroinflammation which vary sensitivity, specificity, validity, reliability. In present study,...
Despite its devastating clinical and societal impact, approaches to treat delirium in older adults remain elusive, making it important identify factors that may confer resilience this syndrome. Here, we investigated a cohort of 93 cognitively normal patients undergoing elective surgery recruited as part the Successful Aging after Elective Surgery study. Each participant was classified either SuperAger (n = 19) or typically aging adult 74) based on neuropsychological criteria, where former...
Reports on the relationships between white matter lesion load (WMLL) and fatigue anxiety in multiple sclerosis (MS) are inconsistent.To investigate association of total tract-specific WMLL with anxiety.Total regional T2 was assessed for 19 tracts 48 MS patients (30 females). ICBM-DTI-81 Atlas-based parcellation combined segmentation T2-weighted magnetic resonance imaging (MRI). Fatigue, anxiety, depression were using Fatigue Impact Scale, State Trait Anxiety Inventory, Beck Depression...
Enlarged perivascular spaces (EPVSs) have been associated with relapses and brain atrophy in multiple sclerosis (MS). We investigated the association of EPVS clinical MRI features disease worsening a well-characterized cohort relapsing-remitting MS patients prospectively followed for up to 10 years.Baseline EPVSs were scored on 1.5T 30 converters moderate-severe disability, nonconverters matched baseline characteristics.EPVS scores not significantly different between nonconverters, nor...
Background:Older surgical patients with Alzheimer's disease (AD) dementia and delirium are at increased risk for accelerated long-term cognitive decline. Objective:Investigate associations between a probabilistic marker of preclinical AD, delirium, Methods:The Succe ssful Aging after Elective Surgery cohort includes older adults (≥70 years) without who underwent elective surgery. 140 preoperative magnetic resonance imaging had≥6 months follow-up. Cortical thickness was measured in...
While the cerebellum plays a critical role in motor coordination and control no studies have investigated its involvement idiopathic mobility impairment community-dwelling elderly. In this study we tested hypothesis that structural changes cerebellar peduncles not detected by conventional magnetic resonance imaging are associated with reduced performance. The analysis involved eighty-five subjects (age range: 75-90 years) who had clinical signs of dysfunction. Based on short physical...
Background:Intracranial volume (ICV) has been proposed as a measure of maximum lifetime brain size. Accurate ICV measures require neuroimaging which is not always feasible for epidemiologic investigations. We examined head circumference useful surrogate in older adults.Methods:99 adults underwent Magnetic Resonance Imaging (MRI). was measured by Statistical Parametric Mapping 8 (SPM8) software or Functional MRI the Brain Software Library (FSL) extraction with manual editing, typically...
Delirium is a common postoperative complication among older patients with many adverse outcomes. Due to lack of validated biomarkers, prediction and monitoring delirium by biological testing not currently feasible. Circulating proteins in cerebrospinal fluid (CSF) may reflect processes causing delirium. Our goal was discover investigate candidate protein biomarkers preoperative CSF that were associated the development surgical patients. We employed nested case–control study design coupled...