A5078665994- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- Nuclear Receptors and Signaling
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Alzheimer's disease research and treatments
- Autoimmune Neurological Disorders and Treatments
- Polyomavirus and related diseases
- Neurological and metabolic disorders
- Peripheral Neuropathies and Disorders
- Genomic variations and chromosomal abnormalities
- Evaluation and Optimization Models
- Sirtuins and Resveratrol in Medicine
- Multiple Sclerosis Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Cannabis and Cannabinoid Research
- Financial Distress and Bankruptcy Prediction
- CNS Lymphoma Diagnosis and Treatment
- Muscle Physiology and Disorders
- Genetic Neurodegenerative Diseases
- Porphyrin Metabolism and Disorders
- Autophagy in Disease and Therapy
Southern Medical University
2016-2025
Nanfang Hospital
2016-2025
Sun Yat-sen University
2011-2015
Third Affiliated Hospital of Sun Yat-sen University
2012-2015
Zhejiang University
2008
Background In addition to their original applications lowering cholesterol, statins display multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely with the dopaminergic system and are strongly implicated in therapeutic paradigms of Parkinson's disease (PD). This study aims investigate how simvastatin impacts on experimental parkinsonian models via regulating NMDA receptors. Methodology/Principal Findings Regional changes rat brain anxiolytic-like activity...
Summary Background In addition to their original applications for lowering cholesterol, statins display multiple neuroprotective effects. Inflammatory reactions and the PI 3K/ AKT /caspase 3 pathway are strongly implicated in dopaminergic neuronal death P arkinson's disease ( PD ). This study aims investigate how simvastatin affects 6‐hydroxydopamine‐lesioned PC 12 via regulating modulating inflammatory mediators. Methods 6‐hydroxydopamine‐treated cells were used neuroprotection of...
Objectives: Cystatin C (Cys C) and high-density lipoprotein (HDL) play critical roles in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) vascular dementia (VaD). However, whether they can be used reliable biomarkers to distinguish patients with from healthy subjects determine severity remain largely unknown. Methods: We conducted a cross-sectional study plasma Cys HDL levels of 88 (43 AD patients, 45 VaD patients) age-matched controls. The was determined based on the...
<b><i>Background:</i></b> Elevation of serum uric acid (UA) is correlated with a decreased risk Parkinson’s disease (PD); however, the association and clinical relevance UA levels in patients PD vascular parkinsonism (VP) are unknown. <b><i>Objective:</i></b> We performed cross-sectional study 160 Chinese VP to determine whether could predict outcomes. <b><i>Methods:</i></b> Serum were divided into quartiles between...
Mitochondrial creatine kinase (MtCK) is vital in the process of mitochondrial energy metabolism, and dysfunction has been implicated pathogenesis Parkinson's disease (PD). Therefore, we speculated that MtCK activity could be altered serum PD patients. However, no studies to date have investigated this specific topic, so sought investigate activities among a cohort 50 patients with 30 age-matched controls were recruited for study. Serum ubiquitous (uMtCK) sarcomeric (sMtCK) assayed using an...
This study explored the association between cerebral metabolic rates of glucose (CMRGlc) and severity Vascular Parkinsonism (VP) Parkinson’s disease (PD). A cross-sectional was performed to compare CMRGlc in normal subjects vs. VP PD patients. Twelve subjects, 22 VP, 11 patients were evaluated with H&Y MMSE, underwent 18F-FDG measurements. Pearson’s correlations used identify potential associations VP/PD CMRGlc. pronounced reduction frontal lobe caudate putamen detected when compared...
Parkinson's disease (PD) is a neurodegenerative caused by the loss of dopaminergic neurons. It characterized static tremors, stiffness, slow movements, and gait disturbances, but it also accompanied anxiety depression. Our previous study showed that atorvastatin could reduce risk PD, mechanism still unclear. In this paper, findings increased muscle capacity coordination movement improved Atorvastatin decrease expression α-synuclein Ser129 NADPH oxidase 2 (NOX2), increase protein LC3II/I,...
Background : Brain iron deposition, low hemoglobin (HGB), and increased heme oxygenase-1 (HO-1) have been implicated in Parkinson’s disease (PD). However, the association among them PD is poorly studied. Objective To explore of level HO-1 with brain deposition HGB PD. Methods A total 32 patients 26 controls were recruited for this study. C57BL/6 male mice used generating 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced chronic model. The Levels serum human subjects assayed by...
Abstract Objective This study aimed at determining the characteristics of systemic inflammation and brain iron deposition in Parkinson's disease (PD) patients. Methods Thirty two PD patients 30 gender‐ as well age‐matched controls were enrolled. Serum interleukin (IL)‐1β, IL‐33, tumor necrosis factor (TNF)‐α, IL‐6, IL‐10, ferritin, iron, total binding capacity (TIBC) levels assayed. Quantitative susceptibility mapping (QSM) was used to quantitatively analyze accumulation regions interest...
Microglia are more susceptible to ferroptosis compared neurons and astrocytes, which may compromise their phagocytic clearance capabilities of α-synuclein (α-syn) in Parkinson's disease (PD). While the beneficial effects physical exercise (PE) on reducing α-syn deposition PD have been highlighted, role PE modulating microglial remains unclear. This study focuses impact inhibiting mitigating accumulation. We demonstrate that voluntary effectively inhibits ferroptosis. Mechanistically,...
Background The elevation of plasma homocysteine (Hcy) and C-reactive protein (CRP) has been correlated to an increased risk Parkinson's disease (PD) or vascular diseases. association clinical relevance a combined assessment Hcy CRP levels in patients with PD parkinsonism (VP) are unknown. Methodology/Principal Findings We performed cross-sectional study 88 Chinese VP using interview the measurement determine if may predict outcomes motor status, non-motor symptoms (NMS), severity, cognitive...
Studies have shown the spatial specificity of cranial iron deposition in different regions Parkinson's disease (PD). However, time-specific patterns are not yet clear. The purpose this study was to investigate time pattern variations and its clinical relevance multiple gray matter nuclei PD using quantitative susceptibility mapping (QSM). Thirty controls 33 patients were enrolled, namely, 11 cases early stage (ESP) 22 advanced (ASP) according Hoehn-Yahr stages. content subcortical covering...
Introduction Anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis is an autoimmune-mediated disease that common in young female patients with ovarian teratomas. With appropriate immunotherapy, most achieve a good prognosis. Nevertheless, some may be refractory to first- and second-line thus alternative treatments are required for these patients. Case presentation: We present case of anti-NMDA teratoma. After the prompt removal teratoma intense immunotherapy was administered, including...
Abstract Background Studies have demonstrated that antinuclear antibodies (ANAs) may be correlated with neuromyelitis optica spectrum disorder (NMOSD). However, the conflicting results of studies about value ANAs in AQP4 antibody‐positive NMOSD patients need to further investigated. Material Case data were collected from 143 NMOSD. Patients divided into two groups based on ANA test results. The analysis clinical characteristics, laboratory tests, and MRI examination compared between groups:...
Mutations in Methyl-CpG binding protein 2 (MECP2) have been identified as the disease-causing mutations Rett Syndrome (RTT). However, no mutation AT-hook 1 domain of MECP2 has reported RTT yet. The function not described either.The clinical and radiological features a girl with progressive hyperactivity loss acquired linguistic motor functions were presented. Next generation sequencing was used to screen causative gene. Effect mutant on histone 3 methylation assessed vitro experiment.The...
Astrocytes are a major constituent of the central nervous system (CNS). Astrocytic oxidative stress contributes to development Parkinson’s disease (PD). Maintaining production antioxidant and detoxification reactive oxygen nitrogen species (ROS/RNS) in astrocytes is critical prevent PD. Study has illuminated that ascorbic acid (AA) stimulates dopamine synthesis expression tyrosine hydroxylase human neuroblastoma cells. However, role regulatory mechanisms AA on still unclear. The purpose our...
The N-methyl-d-aspartate (NMDA) system closely interacts with the dopaminergic and is strongly implicated in pathophysiological mechanisms therapeutic paradigms of Parkinson's disease. This study aims to systematically investigate changes NMDA receptors a wide range brain structures 3 weeks after unilateral medial forebrain bundle lesion by 6-hydroxydopamine (6-OHDA). receptor distributions alterations post-mortem rat were detected [3H] MK-801 binding autoradiography. In 6-OHDA-induced...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease involving both upper and lower motor neurons. The total prevalence of ALS [2-9]/100,000, with an annual incidence rate 3/100,000. progresses rapidly clinically considered to be progressive degeneration the Although this kind rare disease, mortality high once it occurs, which has great impact on patients their families. Currently there no treatment for either sporadic or familial form. Therefore, significance explore diagnosis...
Abstract Background: Anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is an autoimmune-mediated disease, which predominant in young female patients with ovarian teratomas. With proper immunotherapy, most of the achieve good prognosis. Nevertheless, some may be refractory to first and second-line thus new treatments are required help these patients. Case presentation: We present a case anti-NMDA ovary teratoma. After prompt removal teratoma strong immunotherapy including...