A5101946286- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Angiogenesis and VEGF in Cancer
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Microbial Metabolism and Applications
- Heavy Metal Exposure and Toxicity
- Ginger and Zingiberaceae research
- Phytochemistry and biological activity of medicinal plants
- S100 Proteins and Annexins
- Barrier Structure and Function Studies
- Electrolyte and hormonal disorders
- Apelin-related biomedical research
- Trace Elements in Health
- Hormonal Regulation and Hypertension
Shaanxi University of Chinese Medicine
2018-2024
GTx (United States)
2018
Emodin is a natural anthraquinone derivative with numerous beneficial effects, including antioxidant properties, anti-tumor activities, and protecting the nerves. Zinc-induced neurotoxicity plays crucial role in pathogenesis of vascular dementia (VD) Parkinson's disease (PD). Here, protective activity emodin inhibiting zinc-induced its molecular mechanisms such as cellular Zn2+ influx gene expression were examined using human neuroblastoma cells (SH-SY5Y cells). Our findings showed that...
Inhibiting β-amyloid (Aβ)-induced microglial activation is proposed as an effective strategy for the treatment of Alzheimer's disease. Tetrahydroxystilbene glycoside (TSG) main active ingredient Polygonum multiflorum and has a wide range biological properties, including antiinflammation. Here, we focused on function regulatory mechanism TSG in Aβ-induced N9 BV2 cells. The results showed that Aβ induced microglia cells production inflammatory molecules, inducible nitric oxide synthase, oxide,...
Emodin is an active monomer extracted from rhubarb root, which has many biological functions, including anti-inflammation, antioxidation, anticancer, and neuroprotection. However, the protective effect of emodin on nerve injury needs to be further elucidated. The purpose this study investigate neuroprotection special molecular mechanism. Here, activity inhibiting H 2 O -induced apoptosis neuroinflammation as well its mechanisms was examined using human neuroblastoma cells (SH-SY5Y cells)....
Dalbergia Odorifera (DO) has been widely used for the treatment of cardiovascular and cerebrovascular diseasesinclinical. However, effective substances possible mechanisms DO are still unclear. In this study, network pharmacology molecular docking were toelucidate active in treating ischemic stroke (IS). 544 DO-related targets from 29 bioactive components 344 IS-related collected, among them, 71 overlapping common got. Enrichment analysis showed that 12 DO, which regulating 9 important...