A5001835930- Axon Guidance and Neuronal Signaling
- Phagocytosis and Immune Regulation
- Angiogenesis and VEGF in Cancer
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Research Studies
- Toxin Mechanisms and Immunotoxins
- Lung Cancer Treatments and Mutations
- Apelin-related biomedical research
- Robotics and Sensor-Based Localization
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Biomarkers in Disease Mechanisms
- HER2/EGFR in Cancer Research
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Transgenic Plants and Applications
- Genetic Neurodegenerative Diseases
- Chronic Lymphocytic Leukemia Research
- Underwater Vehicles and Communication Systems
- Manufacturing Process and Optimization
- Bacterial Genetics and Biotechnology
- Autonomous Vehicle Technology and Safety
Vaccinex (United States)
2015-2024
University of Minnesota
2019
Emory University
2019
University of California, Los Angeles
2019
Massachusetts Institute of Technology
2008-2015
University of Rochester
2014
Cornell University
2005-2008
City of Hope
2005
National Cancer Institute
2005
PTC (United States)
1996
In this paper we address the problem of drift-free navigation for underwater vehicles performing harbor surveillance and ship hull inspection. Maintaining accurate localization duration a mission is important variety tasks, such as planning vehicle trajectory ensuring coverage area to be inspected. Our approach only uses onboard sensors in simultaneous mapping setting removes need any external infrastructure like acoustic beacons. We extract dense features from forward-looking imaging sonar...
In this work, we develop a monocular SLAMaware object recognition system that is able to achieve considerably stronger performance, as compared classical systems function on frame-by-frame basis.By incorporating several key ideas including multi-view proposals and efficient feature encoding methods, our proposed detect robustly recognize objects in its environment using single RGB camera near-constant time.Through experiments, illustrate the utility of such effectively objects, multiple...
Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell infiltration of CNS, blood-brain barrier (BBB) breakdown, localized myelin destruction, and progressive neuronal degeneration. There exists significant need to identify novel therapeutic targets strategies that effectively safely disrupt even reverse pathophysiology. Signaling cascades initiated semaphorin 4D (SEMA4D) induce glial activation, process collapse, inhibit migration differentiation...
Abstract SIGNAL is a multicenter, randomized, double-blind, placebo-controlled phase 2 study (no. NCT02481674) established to evaluate pepinemab, semaphorin 4D (SEMA4D)-blocking antibody, for treatment of Huntington’s disease (HD). The trial enrolled total 265 HD gene expansion carriers with either early manifest (EM, n = 179) or late prodromal (LP, 86) HD, randomized (1:1) receive 18 monthly infusions pepinemab ( 91 EM, 41 LP) placebo 88 45 LP). Pepinemab was generally well tolerated,...
Many important missions for autonomous underwater vehicles (AUVs), such as undersea inspection of ship hulls, require integrated navigation, control, and motion planning in complex, 3D environments. This paper describes a SLAM implementation using forward-looking sonar (FLS) data from highly maneuverable, hovering AUV performing hull mission. The exactly sparse extended information filter (ESEIF) algorithm is applied to perform based upon features manually selected within FLS images. results...
Abstract Midway through the 2007 DARPA Urban Challenge, MIT's robot “Talos” and Team Cornell's “Skynet” collided in a low‐speed accident. This accident was one of first collisions between full‐sized autonomous road vehicles. Fortunately, both vehicles went on to finish race collision thoroughly documented vehicle logs. collaborative study MIT Cornell traces confluence events that preceded examines its root causes. A summary robot–robot interactions during is presented. The logs from are used...
Study objectives included evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of VX15/2503 in advanced solid tumor patients.Weekly i.v. doses were administered on a 28-day cycle. Safety, immunogenicity, PK, efficacy, T-cell membrane-associated SEMA4D (cSEMA4D) expression saturation, soluble (sSEMA4D) serum levels, biomarker levels evaluated.Forty-two patients enrolled into seven sequential cohorts an expansion cohort (20 mg/kg). was well...
To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of VX15/2503 in a randomized, single-dose, dose-escalation, double-blind, placebo-controlled study enrolling adult patients with MS.Single IV doses or placebo were administered. Ten each randomized (4:1 randomization ratio) into 5 ascending dose cohorts 1, 3, 6, 10, 20 mg/kg. Safety, immunogenicity, PK/PD, MRI, ECG, lymphocyte subset levels evaluated. A Dose Escalation Safety Committee (DESC) approved...
A high-affinity IgG1 kappa murine monoclonal anti-CD20 antibody (IDEC-2B8) was developed for radioimmunotherapy of non-Hodgkin's B-cell lymphoma. stable immunoconjugate (Zevalintrade mark) prepared by reacting IDEC-2B8 with a derivative diethylenetriaminepentaacetic acid, designated MX-DTPA, chelator exhibiting high affinity and retention 90Y. Zevalin exhibited antigen specificity, human tissue reactivity, preclinical safety profile comparable to the native antibody. The conjugate...
Abstract Introduction: MyVax® personalized immunotherapy consists of the tumor-specific Id protein, produced using molecular methods, conjugated to Keyhole limpet hemocyanin (KLH) and administered in a series sc immunizations with GM-CSF. Methods: This is multi-center, randomized, blinded, controlled trial examining safety efficacy MyVax compared control patients previously untreated follicular non-Hodgkin's lymphoma (fNHL). Patients received 8 cycles CVP followed by 6-month rest period. who...
Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family proteins and an important mediator movement differentiation multiple cell types, including those immune, vascular, nervous systems. Blocking binding SEMA4D to its receptors can result in physiologic changes that may have implications cancer, autoimmune, neurological disease. To study effects blocking SEMA4D, we generated, SEMA4D-deficient mice, panel SEMA4D-specific hybridomas react with murine, primate, human SEMA4D....
The integral membrane protein responsible for the transport and phosphorylation of D-mannitol in Escherichia coli, mannitol-specific Enzyme I1 phosphotransferase system (Mr = 60,000), has been purified to apparent homogeneity using a modification previously published procedure (Jacobson, G. R.,
Purified mannitol Enzyme II from Escherichia coli was reconstituted in phospholipid vesicles employing the octylglucoside dilution procedure and shown to catalyze vectorial 1-phosphate:mannitol transphosphorylation. Reconstitution of enzyme into liposomes showed a marked dependency upon concentration with an optimum at 1.2%. The transphosphorylation activity exhibited absolute dependence 1-phosphate as phosphoryl donor, sensitive N-ethylmaleimide, had pH near 6. intravesicular radiolabeled...
Abstract Purpose: The CLASSICAL-Lung clinical trial tested the combination of pepinemab, an IgG4 humanized mAb targeting semaphorin 4D, with PD-L1 inhibitor avelumab to assess effects coupling increased T-cell infiltration and reversal immune suppression via pepinemab sustained activation checkpoint inhibition. Patients Methods: This phase Ib/II, single-arm study was designed evaluate safety, tolerability, efficacy in 62 patients advanced non–small cell lung cancer (NSCLC), including...
Abstract The humanized IgG4 monoclonal antibody VX15/2503 bound with 1 to 5 nmol/L affinity purified recombinant semaphorin 4D (SEMA4D; CD100) produced using murine, rat, cynomolgus macaque, and human sequences. for native SEMA4D expressed on macaque T lymphocytes was approximately 0.6 nmol/L. Tissues from rats macaques demonstrated specific staining only resident lymphocytes. Single-dose one-month toxicology/PK studies used dose levels of 0 100 mg/kg. No toxicity observed either species in...
It is essential for a robot to be able detect revisits or loop closures long-term visual navigation.A key insight that the loop-closing event inherently occurs sparsely, i.e., image currently being taken matches with only small subset (if any) of previous observations.Based on this observation, we formulate problem loop-closure detection as sparse, convex 1-minimization problem.By leveraging fast optimization techniques, are efficiently find closures, thus enabling real-time navigation.This...
Recent applications of robotics often demand two types spatial awareness: 1) A fine-grained description the robot's immediate surroundings for obstacle avoidance and planning, 2) Knowledge position in a large-scale global coordinate frame such as that provided by GPS. Although managing information at both these scales is essential to purpose, each scale has different requirements terms state representation handling uncertainty. In scenario, it can be tempting pick either body-centric or...
Receptor occupancy, or saturation, assays are often utilized in preclinical and clinical development programs to evaluate the binding of a biologic cellular target. These provide critical information regarding dose drug required "saturate" target as well important pharmacodymamic (PD) data. A flow cytometric method was developed measure degree Semaphorin 4D (SEMA4D; CD100) saturation by VX15/2303, an investigational monoclonal antibody specific for SEMA4D.The assay detects VX15/2503, human...
3064 Background: The class I phosphatidylinositol 3-kinases (PI3Ks) regulate cellular functions relevant to oncogenesis. Expression of the PI3K p110δ isoform (PI3Kδ) is restricted cells hematopoietic origin. CAL-101 an isoform-selective inhibitor PI3Kδ that has demonstrated substantial single-agent clinical activity in patients with indolent B-cell non-Hodgkin lymphoma (iNHL) and chronic lymphocytic leukemia (CLL). Methods: This phase study evaluated combination anti-CD20 monoclonal antibody...
Approximately 60 mutants of Salmonella typhimurium were isolated which exhibited altered levels the activities mannitol enzyme II. The grouped into six distinct categories based on their fermentation, transport, chemotaxis, and phosphorylation activities.