An efficient and Brønsted acid free one-pot protocol to directly generate structurally sophisticated α-formylpyrrole derivatives in moderate good yields has been demonstrated, involving an iron-mediated domino oxidation/formylation reaction of readily available 2,3-dihydro-1H-pyrroles dimethyl sulfoxide air atmosphere, which acts as the formyl donor. A possible mechanism is presented.

Abstract An efficient copper‐catalyzed tandem oxidation/α‐formylation reaction of 2,3‐dihydro‐1 H ‐pyrroles in an oxygen atmosphere has been developed. The new is conducted dimethyl sulfoxide (DMSO), which serves as both the carbonyl carbon source and solvent, presence trifluoroacetic acid to directly generate structurally diverse α‐formylpyrrole derivatives one pot moderate good yields. Sensitive aldehyde groups remain intact oxidant, a transition metal salt. A possible mechanism presented....

Super-enhancers (SEs) are exceptionally large enhancers and recognized to play prominent roles in cell identity mammalian species. We surveyed the genomic regions containing clusters of accessible chromatin (ACRs) marked by deoxyribonuclease (DNase) I hypersensitivity Arabidopsis thaliana . identified a set 749 putative SEs, which have minimum length 1.5 kilobases represent top 2.5% largest ACR clusters. demonstrate that associating with these SEs were more sensitive DNase than other...

The ferric perchlorate-mediated reactions of C 60 with various nitriles in o-dichlorobenzene under nitrogen atmosphere afforded the rare fullerooxazoles, which would be difficult to prepare by other methods. A possible reaction mechanism for formation fullerooxazoles was proposed.

Functionalization with the sulfonic acid group as directing in a C-H activation reaction has been revealed for first time. [60]Fullerene employed unprecedented palladium-catalyzed of arylsulfonic acids to afford [60]fullerene-fused sultones.

A convenient and efficient Cu(OAc)2-mediated N-heteroannulation reaction of [60]fullerene with N-sulfonylated o-amino-aromatic methyl ketones or O-alkyl oximes has been reported for the synthesis novel scarce [60]fullerene-fused tetrahydroazepinones -azepinonimines in a highly selective manner. Moreover, possible mechanism involving two pathways is proposed on basis experimental observations.

An efficient and convenient iron-catalyzed protocol has been developed for the synthesis of substituted pyrrolo[1,2-a]quinoxalines from 1-(N-arylpyrrol-2-yl)ethanone O-acetyl oximes through N-O bond cleavage intramolecular directed C-H arylation reactions in acetic acid.

A highly regioselective iodosulfonylation of allenes in the presence CuI and 1,10-phenanthroline has been developed for synthesis various useful ( E)-α-iodomethyl vinylsulfones moderate to excellent yields. This practical reaction is fast, operationally simple, particular, proceeds under very mild conditions afford target products with high regio- stereoselectivity. The selectivity was illustrated by a conceptual DFT analysis.

Soybean production is severely hampered by saline-alkaline stress caused saline-alkalization. Plants have aldehydrogenase (ALDH) family members that convert reactive aldehydes to carboxylic acids remove active aldehyde molecules. However, little known about the increased saline-alkali tolerance ALDH function in soybean. Here, we introduced a previously identified coding gene AhALDH3H1 from Arachis hypogaea into soybean genome investigate its critical role response stress. Transgenic with...

The addition of aluminum chloride to the manganese acetate-mediated radical reaction [60]fullerene with 2-arylmalonates, 2-benzylmalonates, and 2-arylcyanoacetates can switch pathway affords a variety structurally novel scarce [60]fullerene-fused tetrahydronaphthalene indane derivatives. These products are formed probably through addition, followed by Friedel–Crafts-type annulation.

A general and practical methodology for the preparation of novel vinyl-substituted [60]fullerene-fused tetrahydrofurans/pyrans/quinolines through palladium-catalyzed decarboxylative heterocyclizations [60]fullerene with vinylethylene/2-alkylidenetrimethylene carbonates vinyl carbamates was developed. Without additives or ligands, Pd(PPh3)4-catalyzed transformations undergo O- N-heteroannulation processes to efficiently furnish structurally diverse heterocyclic derivatives.

The manganese(III) acetate-mediated radical reaction of [60]fullerene with carboxylic acids in the presence 4-(dimethylamino)pyridine exclusively afforded [60]fullerene-fused lactones. Interestingly, lead(IV) acetate-promoted same selectively gave another type fullerene products, i.e., fullerenyl esters. Possible mechanisms for formation products are proposed.

The facile reaction of [60]fullerene (C(60)) with various aldehydes or ketones in the presence ferric perchlorate successfully afforded rare C(60)-fused 1,3-dioxolanes. A possible mechanism for formation 1,3-dioxolanes is proposed.

Opening a filled cage: Under an aerobic atmosphere, the reaction of Ih-Sc3[email protected]80 with 4,5-diisopropoxybenzyne generated in situ afforded unprecedented open-cage metallofullerene oxygen atom and benzyne addend spanning 13-membered orifice (see picture, green; N blue, Sc pink, C black, O red, H white). Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...

Fullerenyl boronic esters have been prepared by a ferric perchlorate-promoted reaction of [60]fullerene with various arylboronic acids. The obtained fullerenyl could undergo further functionalization diols to afford C60-fused dioxane/dioxepane derivatives. A possible mechanism for the formation has proposed.

An alternative route has been developed for the construction of multisubstituted pyrrole derivatives from readily available, doubly activated cyclopropanes and anilines using an iron-mediated oxidation domino reaction (i.e., sequential ring-opening, cyclization, dehydrogenation reactions). This uses available reactants is tolerant a broad range substrates, with desired products being formed in good to excellent yields.

The first umpolung strategy for the cycloacylation of fullerene using a N-heterocyclic carbene organocatalyst is reported. coupling [60]fullerene with different structural α,β-unsaturated aldehydes efficiently furnishes interesting [60]fullerene-fused cyclopentan-1-ones or cyclohex-2-en-1-ones in good to excellent yields. This new reaction displays wide substrate scope and functional-group tolerance, diverse substituents such as aryl, heteroaryl, alkenyl, alkyl, ester can be installed by...

Abstract A mild and efficient method for the synthesis of thiosulfonates has been developed through a CuI‐catalyzed reductive coupling arenesulfonyl chlorides using Na 2 SO 3 or NaHSO as terminal reductant under nitrogen atmosphere at room temperature. broad scope was obtained in high to excellent yields via this simple, practical economical transformation. The ease handling, use low‐cost readily available reaction materials temperature, efficiency on large scale, make attractive both...

A novel Ag(I)-induced three-component annulation reaction of [60]fullerene with sulfonylhydrazones and nitriles has been developed for the efficient synthesis diverse disubstituted [60]fullerene-fused dihydropyrroles. The exhibits a broad substrate scope excellent functional-group tolerance, also allows fullerene-bound macromolecules.

A highly selective, IBX-promoted reaction has been developed for the oxidative cleavage of inert C(aryl)–N bonds on secondary amides while leaving C(carbonyl)–N bond unchanged. This metal-free proceeds under mild conditions (HFIP/H2O, 25 °C), providing facile access to various useful primary amides, some which would be otherwise unattainable using conventional aminolysis and hydrolysis approaches.

The reaction of o-aminoacetophenones and arylboronic acids catalyzed by copper(II) salts in the presence pyridine under an O2 atmosphere provides a general efficient one-pot preparation biologically interesting acridones. This relay comprises intermolecular Suzuki cross-coupling, intramolecular oxidative C(sp3)–H amination, C(sp2)–H activation with simultaneous rearrangement generated isatin intermediates. strategy tolerates both electron-donating -withdrawing functionalities to afford...

The first example of transition-metal catalyzed multicomponent carboannulation [60]fullerene has been developed. [60]Fullerene, 2-(2,3-allenyl)malonates, and (hetero)aryl iodides undergo a Pd(0)-catalyzed tandem coupling-carboannulation process for regioselective access to novel polysubstituted [60]fullerene-fused cyclopentane derivatives with wide range substrate scope high functional group compatibility. A plausible mechanism involving the formation fullerene-π-allylpalladium complex...

A novel iron-catalyzed vinylogous aldol condensation of Biginelli products with aryl aldehydes has been developed for the syntheses potential bioactive (E)-6-arylvinyl-dihydropyrimidin-2(1H)-ones. These materials are valuable synthetic precursors to drug-like pyrido[4,3-d]pyrimidine derivatives. The amide group at 5-position dihydropyrimidin-2(1H)-ones played an important role in reaction.