A5100325544- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Cardiac Fibrosis and Remodeling
- Acute Ischemic Stroke Management
- Cardiac electrophysiology and arrhythmias
- Corneal surgery and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Radiopharmaceutical Chemistry and Applications
University of Electronic Science and Technology of China
2023-2025
Capital Medical University
2024-2025
Beijing Anzhen Hospital
2025
Italian Resuscitation Council
2024
National Research Council
2024
China Rehabilitation Research Center
2024
Tris Pharma (United States)
2023
Southwest Medical University
2023
Novartis (United States)
2021
Wenzhou City People's Hospital
2009-2021
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous entity including patients different phenotypes of near normal, and supernormal left ventricular (LV) function. To assess the value resting LV elastance (also known as force) transthoracic echocardiography (TTE) to identify HFpEF phenotypes. In prospective, observational, multicenter study, 2380 were recruited from July 2016 May 2024. Systolic blood pressure (SBP) was measured. We assessed end-diastolic volume (EDV),...
To investigate the protective effect of Polygonatum sibiricum polysaccharide (PSP) on retina in diabetic rats.A total 120 Sprague-Dawley rats were randomly divided into blank control, control model (meaning diabetes mellitus), and mellitus with PSP intervention high, medium low doses groups. The difference retinal vascularization between groups was evaluated by fluorescein isothiocyanate-dextran perfusion. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining used to...
Abstract In addition to the known antitumour effects of ursolic acid (UA), increasing evidence indicates that this molecule plays a role in cardiac protection. study, on heart mice treated with doxorubicin (DOX) were assessed. The results showed improved left ventrical fractional shortening (LVFS) and ejection fraction (LVEF) heart, increased nitrogen oxide (NO) levels, inhibited reactive oxygen species (ROS) production decreased apoptosis doxorubicin. Mechanistically, AKT endothelial...
Apoptosis plays a crucial role in regulating cardiomyopathy and injuries of coxsackievirus B3 (CVB3)-induced viral myocarditis (VM). It has been reported that Astragaloside IV (AST-IV) from Astragalus membranaceus could inhibit apoptosis under variety pathological conditions vivo or vitro. However, the functional roles AST-IV CVB3-induced VM still remain unknown. Here, we found significantly enhanced survival for mice. protected mice against virus characterized by increased body weight,...
Background Studies demonstrated sex differences in outcomes following acute myocardial infarction, with women more likely to develop heart failure (HF). Sacubitril/valsartan has been shown reduce cardiovascular death and HF hospitalizations patients reduced ejection fraction. Methods Results A total of 5661 (1363 [24%]) infarction complicated by left ventricular fraction (≤40%), pulmonary congestion, or both ≥1 8 risk‐augmenting factors were randomized receive sacubitril/valsartan ramipril....
Left ventricular (LV) function is typically evaluated through LV ejection fraction (EF), a robust indicator of risk, showing nonlinear increase in mortality rates below 40%. Conversely, excessively high EF values (> 65%) also correlate with elevated mortality, following U-shaped curve, its nadir observed between 50% and 65%. This underscores the necessity for improved identification hypercontractile phenotype. However, not synonymous contraction function, as it can fluctuate independently...
ABSTRACT Purpose This study aims to elucidate the characteristics of segment myocardial work (MW) and reserve function through exercise stress echocardiography (ESE) explore associations between MW parameters capacity in patients with left ventricular remodeling due hypertension (LVRH). Methods A total 105 LVRH (LVMI ≥ 115 g/m 2 for males LVMI 95 females) underwent ESE examination following established guidelines. Additionally, 59 healthy subjects served as a control group. Speckle tracking...
Background/Objective: Cardiomyopathy is a key cause of cardiovascular mortality in critically ill patients. Although red blood cell distribution width (RDW) recognized as potential prognostic biomarker, its variations during ICU admission and interaction with treatments such β-blockers are not well understood across different cardiomyopathy subtypes. To assess the significance RDW dynamics their β-blocker therapy predicting 365-day among patients dilated, hypertrophic, restrictive...
This study investigated the effects of naringin on platelet aggregation and release in hyperlipidemic rabbits, underlying mechanisms. The safety was also investigated. rabbits were orally administered 60, 30 or 15 mg/kg once a day for 14 days after being fed high fat/cholesterol diet four weeks. Following two weeks drug administration, degree induced by arachidonic acid, adenosine diphosphate collagen significantly reduced at certain doses compared with those model group (P<0.01). levels...
To investigate the effects of levocarnitine on cardiac function, urinary albumin (ALB), high-sensitivity C-reactive protein (hs-CRP), brain natriuretic peptide (BNP), and troponin in patients with coronary heart disease (CHD) failure (HF). In total, 246 CHD-caused HF were selected randomly divided into Group A B. fully automatic biochemical analyzer was used to measure levels ALB, hs-CRP, BNP, both groups patients, expression LVDD LVEF detected by color ultrasonography. Patients B...
Free fatty acids (FFAs) predicted the risk of heart failure (HF) and were elevated in HF with very low left ventricular ejection fraction (LVEF) compared to healthy subjects. The aim this study was investigate whether total levels FFA plasma differed patients preserved (HFpEF), mid-range (HFmrEF), reduced (HFrEF) association three categories. One hundred thirty-nine HFpEF, HFmrEF HFrEF investigated study. Plasma measured using commercially available assay kits, LVEF calculated by...
Objectives: Percutaneous coronary interventions (PCIs) save countless acute myocardial infarction (AMI) patients. However, endothelial injury is still an inevitable complication. Circulating microparticles (MPs) play important roles in vascular dysfunction. Whether PCI affects function of MPs remains unclear. Methods: were obtained from AMI patients (n = 38) both preoperatively and 24 h after PCI, healthy subjects 20). origins tested by flow cytometry. Rat thoracic aortas incubated with to...
The incidence of heart failure was significantly increased in patients with diabetic cardiomyopathy (DCM). therapeutic effect triptolide on DCM has been reported, but the underlying mechanisms remain to be elucidated. This study is aimed at investigating potential targets as a strategy for using network pharmacology approach. Triptolide and its were identified by Traditional Chinese Medicine Systems Pharmacology database. DCM-associated protein comparative toxicogenomics database GeneCards...
The ability to detect left ventricular (LV) apical dyskinesis, the hallmark of an aneurysm, is important requirement diagnostic cardiac imaging modalities that perform wall motion analysis. Our investigation assessed gated blood pool single-photon emission-computed tomography (GBPS) automatically LV using magnetic resonance (CMR) as reference standard.GBPS data were analyzed for 41 patients with congestive heart failure or cardiomyopathy and compared ECG-gated TrueFISP CMR evaluations. An...
Objective: To compare the efficacy of 40 mg and l0 atorvastatin on serum levels 8-Hydroxy-Guanin (8-OHdG) cardiac function in patients with ischemic cardiomyopathy (ICM).Methods: One hundred twenty three hospitalized ICM 120 healthy controls were included this study. All subjects randomly divided into two groups: 10 mg/d group (n=62) (n=61). Serum C-reactive protein (CRP), creatine kinase, glutamic-pyruvic transaminase, lipids B-type natriuretic peptide (BNP) tested all both at initial phase...
Methods Subjects were prospectively enrolled and brain natriuretic peptide (BNP) N-terminal proBNP (NT proBNP) obtained prior to CMR examination. First-pass perfusion was performed in sagital coronal planes covering the main pulmonary artery left atrium using a saturation recovery SSFP sequence with 0.005 0.01 mmol/kg gadopentetate. PTT measured as time interval between peak signal intensity normalized heart rate. cine imaging for ventricular structure function evaluation. All participants...
To explore whether the traditional Chinese medicine (TCM) Bu Jing Yi Shi Tablets alters expression of scleral TGF-β1 and Smad3 in guinea pigs with form-deprivation myopia (FDM). Sixty-five were randomly divided into control, model, low-, medium-, high-dose treatment groups. Except for control group, FDM was induced by covering right eye each animal opaque latex. The groups gavaged different suspension concentrations Tablets. Refraction axial length performed before after induction. At end...