ABSTRACT: To develop a spore inactivation strategy, the effect of 15‐min hydrostatic pressure treatments (550 and 650 MPa) at 55 75 °C in citric acid buffer (4.75 6.5 pH) on spores 5 isolates Clostridium perfringens type A carrying gene that encodes C. enterotoxin ( cpe ) chromosome (C‐ ), 4 plasmid (P‐ 2 strains sporogenes were investigated. Treatments MPa, pH moderately effective against P‐ (approximately 3.7 decimal reduction, DR) 2.1 but not for C‐ 1.0 spores. 4.75 3.2 2.5 1.2 when...

Abstract Background The clinical presentation of dengue fever has a wide spectrum; unussual manifestations have been reported and with the rising disease burden, atypical are also on rise, but underreported often missed due to lack awareness among health care professionals. In Argentina we witnessing largest historical outbreak in 2024. objective study is profile outcome severe children. Methods All children (0–18 y age) confirmed as at tertiary hospital Buenos Aires, between January...

ABSTRACT Ciliated adenocarcinomas are rare non‐terminal respiratory unit‐type lung characterised by ciliated cells with nuclear atypia and glandular or papillary architecture. A few cases of adenocarcinoma the have been reported. These negative for TTF1 either KRAS (25%) EGFR (9%) mutations. case a well‐differentiated architecture, focal residual cilia, apical snouts, CHEK2 p53 mutations diagnosed at stage IV(T4NxM0) is The article describes cytomorphological features this tumour, potential...

In our article, we report additional cytolorphologic features of MASC. addition to vacuolated cells/histiocytoid cells and colloid‐like material in the background noticed nuclear membrane irregularities, grooving, hyalinized tissue fragments cell block. These can serve as important diagnostic clues making a diagnosis MASC on cytology.

Cases of epithelioid hemangioendothelioma with WWTR1::CAMTA1 fusion can show rhabdoid cytomorphology. Lack intracytoplasmic luminal spaces, marked cytomorphology, and variability in the expression vascular markers makes diagnosis EHE challenging. Therefore, a high level suspicion ancillary studies (immunohistochemistry next generation sequencing) help reach definitive these cases.

Objective To identify differences in 3‐year overall survival (OS) and disease‐free (DFS) based on race patients with tonsillar squamous cell carcinoma. Methods We retrospectively analyzed 80 carcinoma of the tonsil treated between 2006 2015. Overall DFS curves comparing white black were generated using Kaplan‐Meier method. Cox regression was used to determine covariables associated OS DFS. Results Forty‐one percent this cohort 59% white. Three‐year for 45.5% versus 88.1% ( P = 0.003). 41.1%...

α-methylacyl coenzyme A racemase (AMACR) and insulin-like growth factor-II mRNA-binding protein 3 (IMP3) are 2 markers helpful in detecting difficult cases of dysplasia Barrett esophagus (BE). However, no comparison studies have been performed to assess their performance the same patient population.The aim our study was compare immunohistochemical expression IMP3 AMACR dysplastic lesions early adenocarcinoma (EAC) arising BE evaluate sensitivity specificity.A total 98 [BE negative for...

The salivary gland neoplasm of unknown malignant potential (SUMP) category reflects the cytomorphologic overlap and complexity reporting cytology in Milan system. It includes neoplasms for which a diagnosis specific entity cannot be made and, more importantly, carcinoma entirely excluded. For risk stratification, subcategorization SUMP based on predominant cell type is recommended. This study was aimed at evaluating (RON) malignancy (ROM) basaloid oncocytic subtypes category.A retrospective...

Immune thrombocytopenia is characterized by antibody-mediated platelet destruction and insufficient production resulting in isolated the absence of underlying cause. Despite many treatment options, low-to-intermediate rates remission high resistance to are seen. Approximately 20% patients do not attain a hemostatic count after splenectomy or first- second-line medical approaches. A new option these cases with romiplostim. Bone marrow (BM) fibrosis has been reported clinical trials We report...

Spindle cell lesions of the salivary glands are rare and account for less than 3% gland aspirates. A definitive classification neoplasms by fine needle aspiration is possible most common but remains a challenge entities. We present case 72-year-old male with solitary fibrous tumour (SFT) submandibular mimicking myoepithelial-rich pleomorphic adenoma (PA). In this article, we discuss novel insights that help differentiate SFT from PA other spindle lesions.

Giant cell tumours (GCT) of the skull base account for approximately 1% all GTC bone.Despite being considered as a benign neoplasm, they are locally aggressive with high recurrence rates after incomplete surgery.Due to small number cases reported in base, standardized treatment remains unclear.Even new surgical techniques, complete resection is not always possible without functional compromise.Therefore, adjuvant therapy essential enhance local control and quality life.We described case...

An adult water chevrotain was euthanized due to severe non-responsive pododermatitis. Incidentally, multiple coalescing cholesterol granulomas were identified within the right diencephalon, characterized by presence of foamy macrophages and clefts consistent with encephalic xanthomas. No clinical signs or predisposing conditions associated this finding identified. This is first known report xanthomas in species.

Amoebic infections have been described in humans and animals, causing lesions specific organs or as systemic infections. In both animals humans, immunocompromised patients are predisposed to the infection. The present report macroscopic histologic findings a Quarter horse filly who presented with infection caused by Acanthamoeba spp. that was characterized multinodular lung, kidney, heart, submandibular lymph node, lip. Histopathology revealed dense inflammatory infiltrates composed of...

Hyalinising clear cell carcinoma (HCCC) is a rare salivary gland neoplasm characterised by an EWSR1::ATF1 fusion. Rare cases showing EWSR1::CREB1 rearrangements have been reported. This article presents case of HCCC with novel EWSR1-CREB1 fusion, diffuse eosinophilic appearance, cytomorphological findings, PAS-negativity, and late regional distant lymph node metastases.

Cases of metaplastic pleomorphic adenoma can be diagnostically challenging. Many these cases fall into the Milan system's SUMP category, and some may misdiagnosed. The author shows a case with extensive squamous mucinous metaplasia novel MALAT1::PLAG1 fusion. declares that there are no conflicts interest regarding publication this manuscript. data support findings study available from corresponding upon reasonable request.

ABSTRACT Pleomorphic adenoma (PA) is the most common salivary gland neoplasm worldwide (50%–70%). Most cases of PA are straightforward diagnoses. However, diagnosis may be challenging due to morphological diversity PAs, which in many caused by predominance one three components or presence metaplastic epithelium. We present case a 64‐year‐old male with history prostate cancer and right submandibular excision 16 years ago an unknown previous recent regrowth his mass surgical bed. The tumour...