A5050395217- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Ion channel regulation and function
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Connexins and lens biology
- Estrogen and related hormone effects
- Neuroscience and Neural Engineering
- Neurotransmitter Receptor Influence on Behavior
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Animal Ecology and Behavior Studies
- Prenatal Substance Exposure Effects
- Cholinesterase and Neurodegenerative Diseases
- Pesticide Exposure and Toxicity
New York Medical College
2016-2025
Penn State Milton S. Hershey Medical Center
2023
Catalyst Foundation
2020
Albert Einstein College of Medicine
2003-2012
Montefiore Medical Center
1995-2011
York University
2011
Yeshiva University
1992-2009
Neurology, Inc
2003-2007
Czech Academy of Sciences, Institute of Physiology
1987-2004
Czech Academy of Sciences
1987-2004
Blast exposure is associated with chronic traumatic encephalopathy, impaired neuronal function, and persistent cognitive deficits in blast-exposed military veterans experimental animals.
Summary: Purpose : Estrogens have neuroprotective effects in ischemia, stroke, and other conditions leading to neuronal cell death (e.g., Alzheimer's disease). The present study examined whether estrogens may after seizures. Methods kainic acid model was used determine if protect hippocampal cells status epilepticus adult female rats. Rats were ovariectomized 1 week before hormone replacement. β‐Estradiol benzoate (EB; 2 μg 0·1 mL of oil) injected subcutaneously 48 24 hours seizure testing....
Infantile spasms (a catastrophic epileptic syndrome of childhood) are insensitive to classic antiepileptic drugs. New therapies limited by lack animal models. Here we develop a new model flexion based on prenatal exposure betamethasone combined with postnatal administration N-methyl-D-aspartic acid (NMDA) and determine brain structures involved in the induction spasms.Pregnant rats received two doses day 15 gestation. Offspring was injected NMDA 15. Effects adrenocorticotropin therapy...
Abstract In adult diabetic patients, periods of hyperglycemia may be associated with exacerbation focal seizures. Our objective was to determine in the rats correlation between seizure susceptibility and extracellular glucose concentration two models Male were injected doses streptozocin (40mg/kg IP) on 2 consecutive days induce hyperglycemia. Controls either received vehicle or not injected. After weeks, blood measured, subjected flurothyl test. Another group solution (20%, 5ml 30 minutes...
Purpose: To determine whether a new model of cryptogenic infantile spasms consisting prenatal priming with betamethasone and postnatal trigger by N-methyl-d-aspartate (NMDA) responds to chronic adrenocorticotropic hormone (ACTH) treatment, has electroencephalography (EEG) signature, efficacy treatments, behavioral impairments similar those in human spasms. Methods: Rats prenatally primed on gestational day 15 were used. Spasms triggered NMDA between days (P) 10 single session or multiple...
Idiopathic generalized epilepsy (IGE) syndromes represent about 30% of all epilepsies. They have strong, but elusive, genetic components and sex-specific seizure expression. Multiple linkage population association studies connected the bromodomain-containing gene BRD2 to forms IGE. In mice, a null mutation at homologous Brd2 locus results in embryonic lethality while heterozygous Brd2+/− mice are viable overtly normal. However, using flurothyl model, we now show, that compared Brd2+/+...
Summary: Purpose : With intraperitoneal N ‐methyl‐D‐aspartate (NMDA; 15–200 mg/kg) administration, we attempted to develop an animal model of age‐specific West syndrome serve for testing putative anticonvulsant drugs and determine the mechanisms this disorder. Methods Experiments were performed in 12‐, 18‐, 60‐day‐old (adult) rats. The effects systemic pretreatment with hydrocortisone (5–25 mg/kg), pyridoxine (20–250 sodium valproate (VPA; 200 400 against NMDA‐induced automatisms,...
Summary: Purpose: Animal studies and anecdotal human case reports have indicated that the subthalamic nucleus (STN) may be a site of anticonvulsant action. Methods: We tested hypothesis continuous electrical stimulation STN inhibits seizures acutely. determined effects three frequencies, 130 Hz, 260 800 on generalized clonic tonic–clonic flurothyl seizures. Adult male rats were implanted with concentric bipolar stimulating electrodes in bilaterally. After recovery, underwent to compare each...
The dentate gyrus filters incoming activity into the hippocampus proper. It plays a role in learning and memory pathological states such as epilepsy. Some of hilar interneurons express neuropeptide Y (NPY), which modulates granule cell activity. A subpopulation NPY-expressing inhibitory is sensitive to seizure-induced damage. Pretreatment with β-estradiol ovariectomized rats protects against injury, including NPY-containing damage-sensitive subpopulation. Here, we demonstrate that enhances...
ATP- and adenosine-mediated signaling are prominent types of glia-glia glia-neuron interaction, with an imbalance ATP/adenosine ratio leading to altered states excitability, as seen in epileptic seizures. Pannexin1 (Panx1), a member the gap junction family, is ATP release channel that expressed astrocytes neurons. Previous studies provided evidence supporting role for purinergic-mediated via Panx1 channels seizures; using mice global deletion Panx1, it was shown these contribute maintenance...
Summary Objective Fibroblast growth factor homologous factors (FHFs) are brain and cardiac sodium channel‐binding proteins that modulate channel density inactivation gating. A recurrent de novo gain‐of‐function missense mutation in the FHF1(FGF12) gene (p.Arg52His) is associated with early infantile epileptic encephalopathy 47 (EIEE47; Online Mendelian Inheritance Man database 617166). To determine whether FHF1 sufficient to cause EIEE establish an animal model for EIEE47, we sought engineer...
Summary: Purpose: Development and sex hormones are important determinants of seizure susceptibility. Seizures develop in the immature brain more readily than mature brain. Male children experience a higher incidence epilepsy or unprovoked seizures do female children. Sex‐specific differences development seizure‐suppressing neuronal networks may account, at least part, for this increased age‐ sex‐related susceptibility to seizures. The control can be influenced by substantia nigra pars...
Abstract In vivo , severe hypoglycemia is frequently associated with seizures. The hippocampus a structure prone to develop seizures and seizure‐induced damage. Patients repeated hypoglycemic episodes have frequent memory problems, suggesting impaired hippocampal function. Here we studied the effects of moderate on primarily generalized flurothyl‐induced in and, using EEG recordings, determined involvement Moderate systemic had proconvulsant clonic (forebrain) During seizures, seizure...
Summary Estrogens are essential for normal brain functions. The effects of estrogens on seizures contradictory. More studies necessary to determine under which conditions the have proconvulsant and when may beneficial action in patients with epilepsy.
We have developed a new model of cryptogenic infantile spasms with prenatal betamethasone brain priming to increase susceptibility development-specific triggered by N-methyl-d-aspartate (NMDA). A recent clinical study linked severe stress increased risk for development spasms. Here, we determined whether restraint (2 × 45 min) in rats on gestational day 15 would develop postnatal 15. Prenatal significantly accelerated onset and number NMDA-triggered compared handled controls. single...