A5100415170- Herpesvirus Infections and Treatments
- Functional Brain Connectivity Studies
- Biomarkers in Disease Mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Healthcare and Venom Research
- MicroRNA in disease regulation
- Neural dynamics and brain function
- Cell Adhesion Molecules Research
- Traditional Chinese Medicine Studies
- Medical Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Ovarian function and disorders
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Acute Ischemic Stroke Management
- Microbial Natural Products and Biosynthesis
- Lipoproteins and Cardiovascular Health
- Respiratory viral infections research
- Pelvic floor disorders treatments
- Endometriosis Research and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Circular RNAs in diseases
- Lymphoma Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Reproductive System and Pregnancy
Yunnan Agricultural University
2012-2025
Guangzhou University of Chinese Medicine
2025
Chengdu University of Traditional Chinese Medicine
2025
Sun Yat-sen University
2014-2024
Xi'an Technological University
2024
Third Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2010-2024
Longgang Central Hospital
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2019-2024
Hebei Eye Hospital
2024
Abstract The objective of this study was to investigate the mechanism curcumin in diabetic foot ulcer (DFU) wound healing. A DFU rat model established, and fibroblasts were cultured a high-glucose (HG) environment create cell model. Various techniques, including Western blot, RT‒qPCR, flow cytometry, Transwell, scratch test H&E staining, employed measure levels relevant genes proteins, as well assess proliferation, apoptosis, migration, pathological changes. results showed that...
Fluorine may result in damage to teeth, bones and other body tissues, is a serious public health problem. SIRT1 deacetylates FOXOs, which brings about apoptosis autophagy promotion or suppression. induce cell apoptosis, however, the role of induced by fluorine still poorly understood, interaction between FOXOs should be further illustrated. Therefore, this study investigated mechanisms underlying NaF- osteoblast-like MC3T3-E1 cells vitro through activating inhibiting SIRT1. Via RT-PCR,...
Noninvasive testing and continuous monitoring of ultralow-concentration hormones in biofluids have attracted increasing interest for health management personalized medicine, which saliva could fulfill the demand. Steroid sex such as progesterone (P4) β-estradiol (E2) are crucial female wellness reproduction; however, their concentrations can vary down to sub-pM constantly fluctuate over several orders magnitude. This remains a major obstacle toward user-friendly reliable at home with...
Schistosomiasis japonicum remains a considerable economic and public health concern in China, the Philippines Indonesia. Currently available measures to control unique intermediate host Oncomelania hupensis are frequently associated with severe side effects. Previous studies have demonstrated that linalool-rich extracts from various plants exhibited promising biological activities including cytotoxic, anti-microbial anti-parasitic properties.We identified components of leaf Cinnamomum...
High invasiveness is a biological and clinical characteristic of glioblastoma predicts poor prognosis patients. Quercetin, natural flavonoid compound, exhibits anticancer activity. However, we have limited understanding the possible underlying mechanism quercetin in glioblastoma. In this study, investigated effect human cells. Our results showed that markedly suppressed viability cells vitro vivo, significantly inhibited cell migration invasion. Moreover, reversed EMT-like mesenchymal...
Background: Pancreatic cancer is a malignancy with high mortality rate and worse prognosis. Recently, public databases bioinformatics tools make it easy to develop the prognostic risk model of pancreatic cancer, but aging-related signature has not been reported. The present study aimed identify an potential value for patients. Method: Gene expression profiling human clinical information were derived from Cancer Genome Atlas database (TCGA). Aging-related gene sets downloaded Molecular...
Hydropericardium hepatitis syndrome (HHS) is primarily caused by fowl adenovirus serotype 4 (FAdV-4), causing high mortality in chickens. Although vaccination strategies against FAdV-4 have been adopted, HHS still occurs sporadically. Furthermore, no effective drugs are available for controlling infection. However, type I and III interferon (IFN) crucial therapeutic agents viral The following experiments were conducted to investigate the inhibitory effect of chicken IFN FadV-4. We expressed...
Nocardia is one of the causing agents bovine mastitis and increasing prevalence nocardial in shape serious outbreaks has been reported from many countries. However, mechanisms by which this pathogen damages mammary epithelial cells (bMECs) not yet studied. Therefore, study was designed with aim to evaluate apoptotic effects elicited investigate pathway induce apoptosis bMECs. Clinical N. cyriacigeorgica strain used infect bMECs for different time intervals, viz. 1 h, 3 6 12 18 then induced...
Abstract Wearable near/in‐sensor neuromorphic computing is driving next‐generation human‐artificial intelligence (AI) interface, the Internet of Things, and intelligent robots, with reservoir (RC) playing a pivotal role in advancing AI hardware, yet its potential remains underexplored. Herein, an all‐polymer accumulation‐mode organic electrochemical synaptic transistor (OEST) demonstrated controlled ionic dynamics that can facilitate high‐performance wearable RC while allowing entire...
Background Uterine corpus endometrial carcinoma (UCEC) is one of the most common cancers in women, yet lacks specific and sensitive tumor markers for diagnosis, as traditional like CA125 show limited specificity. This study investigates clinical significance prognostic value CDH18, a calcium-dependent adhesion protein linked to progression, UCEC. Methods Clinical data from UCEC patients were sourced The Cancer Genome Atlas (TCGA) database. Pan-cancer analysis, differential expression...
It is estimated that 90% of deaths from food poisoning in China can be attributed to Amanita poisoning, whose main toxin α-amanitin. Studies showed apoptosis plays a critical role liver injuries induced by Although the relationship between autophagy and different models has been addressed many times, whether pro or con effect on α-amanitin-induced not clarified. Therefore, this study was conducted explore Hepa1-6 cells. A 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT)...
Background . PD patients present high incidence of pain with unknown pathogenesis. Objective We investigated the relation COMT polymorphisms rs4633 and rs6267 pain. Subjects Methods One hundred 105 controls were evaluated simplified Mc GILL scale VAS scale. assessed H&Y grade, UPDRS score, HAMD Polymorphisms detected by PCR direct sequencing. Results Fifty-seven percent experienced pain, consisting PD-related (64.91%) (the majority was dystonia pain) non-PD-related (35.09%) (psychogenic...
Pentraxin-3 (PTX3) is an inflammatory marker thought to be more specific cardiovascular inflammation than C-reactive protein (CRP). Our aim was assess the prognostic value of PTX3 in patients with stable coronary artery disease (CAD) after drug eluting stent (DES) implantation. Plasma levels were measured before percutaneous intervention (PCI) and at 24 h post-PCI 596 consecutive CAD. Patients followed up for a median 3 years (range 1–5) major adverse events (MACEs). We found that plasma...
In present work, non-isothermal crystallization behavior for novel Cr50Fe6Co7Mo14C15B6Y2 metallic glass (MG) with super high content of Cr and excellent merits was investigated by differential scanning calorimeter X-ray diffraction. Both the Kissinger Ozawa methods show that transition is much harder than other transitions a larger apparent activation energy (E). While, growth process second event easiest process, since it possesses smallest E. Meanwhile, local established...
Abstract Aim This study aimed to explore the link between neutrophil extracellular traps (NETs) and childhood asthma, investigate ability of nitric oxide (NO) induce NETs in asthmatic children find inhibitors reduce NO synthesis pathway. Methods A total 49 with mild persistent asthma were included 20 healthy children's blood samples collected as controls. Children divided into symptomatic asymptomatic groups according presence or absence symptoms on day collection. Neutrophils peripheral...
Polylactide (PLA) microspheres were prepared using the solid-in-oil (S/O) spray-drying method to achieve sustained release of a hydrophilic drug for treatment tuberculosis, via intratracheal instillation. Isoniazid (IN), low-molecular-weight drug, was used as model drug. The effects various sizes micronized IN powder, different drug/polymer ratios, process parameters, and drug-release characteristics studied optimize manufacturing parameters. A high entrapment efficiency (87.3%) obtained...
CCAAT enhancer-binding protein alpha (CEBPA, also known as C/EBPα) is a transcription factor that plays an essential role in regulating terminal differentiation and cell proliferation of many tissues.The objective this study was to explore the potential function CEBPA ovarian cancer.The expression cancer samples adjacent normal tissues evaluated by qRT-PCR.The putative cells immunohistochemistry, western blot, viability assay, BrdU incorporation soft agar colony formation Transwell migration...