A5048731309- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Circular RNAs in diseases
- Aortic aneurysm repair treatments
- Spinal Cord Injury Research
- Alkaloids: synthesis and pharmacology
- Protease and Inhibitor Mechanisms
- Systemic Lupus Erythematosus Research
- Pain Mechanisms and Treatments
- MicroRNA in disease regulation
- Mathematical and Theoretical Epidemiology and Ecology Models
- Psoriasis: Treatment and Pathogenesis
- Aortic Disease and Treatment Approaches
- Nonlinear Differential Equations Analysis
- Neuropeptides and Animal Physiology
- Fractional Differential Equations Solutions
- Nerve injury and regeneration
- interferon and immune responses
Second Xiangya Hospital of Central South University
2018-2025
Central South University
2018-2025
Huzhou University
2016-2023
Third People's Hospital of Huzhou
2016-2022
Shandong Maternal and Child Health Hospital
2019
Southwest University
2014-2016
Ferroptosis has emerged to be a promising approach in cancer therapies; however, colorectal (CRC) is relatively insensitive ferroptosis. Exactly how the gut microenvironment impacts ferroptotic sensitivity of CRC remains unknown. Herein, by performing metabolomics, we discovered that butyrate concentrations were significantly decreased patients. Butyrate supplementation sensitized mice ferroptosis induction, showing great vivo translatability. Particularly, treatment reduced resistance stem...
Abstract Background Sepsis-associated encephalopathy (SAE) increases the mortality of septic patients, but its mechanism remains unclear. The present study aimed to investigate roles T lymphocytes, proBDNF, and their interaction in pathogenesis SAE. Methods Fear conditioning tests were conducted for cognitive assessment lipopolysaccharide (LPS, 5 mg kg −1 )-induced mice. Meninges peripheral blood harvested flow cytometry or qPCR. FTY720 monoclonal anti-proBDNF antibody (McAb-proB) used...
Psoriasis is an immune-related inflammatory systemic condition characterized by dysregulated keratinocyte proliferation and chronic inflammation. Tanshinone I (Tan-I) has recently been discovered to have immunomodulatory properties, but its role mechanisms in treating psoriasis remain unclear. To evaluate the efficacy of Tan-I treatment determine involved. An imiquimod (IMQ)-induced psoriasis-like mouse model was treated topically with (7.5 mg/kg/d) or a vehicle. Disease severity evaluated...
The current research study is devoted to analyze the fractional order co-infection disease epidemic model endowed with Caputo derivative. We also investigate qualitative analysis of via using classical fixed point theory. Moreover, stability results regarding Ulam–Hyers type are investigated for proposed model. Apart from this, simulate model, Adam–Bashforth Moulten (ABM) method utilized handle required results. By Matlab, graphical presentation against various orders given.
The present study involves diversity and biological activities of the endophytic fungal community from Distylium chinense, a rare waterlogging tolerant plant endemic to Three Gorges Reservoir. This has been conducted hypothesizing that microbial communities in TGR area would contribute host tolerating range abiotic stress such as summer flooding, infertility, drought, salinity soil erosion etc., they may produce new metabolites, which possess plentiful bioactive property, especially...
Inappropriate expansion of antibody-secreting cells (ASCs) is typical systemic lupus erythematosus (SLE), but the regulatory signaling pathogenic ASCs unclear. The present study shows that brain-derived neurotrophic factor precursor (proBDNF) and its high-affinity pan-75 neurotrophin receptor (p75NTR) are highly expressed in CD19+CD27hiCD38hi patients with SLE CD19+CD44hiCD138+ lupus-like mice. increased proBDNF+ were positively correlated clinical symptoms higher titers autoantibodies SLE....
Abstract Acute type A aortic dissection (ATAAD) is a lethal pathological process within the aorta with high mortality and morbidity. T lymphocytes are perturbed implicated in clinical outcome of ATAAD, but exact characteristics cell phenotype its underlying mechanisms ATAAD remain poorly understood. Here we report that CD4 + cells from patients presented hypofunctional was correlated poor outcomes. Whole transcriptome profiles showed ferroptosis lipid binding pathways were enriched cells....
Brain-derived neurotrophic factor precursor (proBDNF) has been reported to strengthen the dysfunction of monocytes/macrophages in animal studies. However, it is still unknown roles proBDNF monocytes inflammatory diseases humans. In present study, we showed that and pan receptor p75 were significantly upregulated from healthy donors (HD) after lipopolysaccharide treatment. Exogenous treatment CD40 proinflammatory cytokines expression including interleukin (IL)-1β, IL-6, tumor necrosis...
We investigated the role of microRNA (miR)-9 in modulating chemoresistance hepatocellular carcinoma (HCC) cells.MiR-9 was overexpressed or knocked down HCC cell lines.Cell viability, proliferation, expression EIF5A2 and epithelial-mesenchymal transition (EMT)-related proteins were examined.HCC cells overexpressing miR-9 more sensitive to cisplatin; knockdown yielded opposite result.The vivo nude mouse xenograft tumors same results.EIF5A2 identified as a potential target miR-9, where...
<title>Abstract</title> Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe conditions with high morbidity mortality, effective treatments limited. Neuroimmune interactions play a critical role in homeostasis, but it remains unclear if specific brain regions regulate inflammation. Here, we unveil the of neuroimmune signaling ALI, focusing on regulatory function corticotropin-releasing hormone (CRH) neurons paraventricular nucleus (PVN) hypothalamus. Using viral...
Abstract Purpose Electroencephalography (EEG) is commonly used to assess sedation levels in general anesthesia, but its ability indicate perioperative trauma and inflammation activation remains unclear. This study examines the relationship between nociception index (NOX), an EEG-derived metric, related immune changes surgical patients. Methods Patients aged 18 75 years scheduled for elective surgery under without chronic pain, hepatic or renal dysfunction, pregnancy, intensive care unit...
The objective of this study is to explore the biological roles microRNA-101-5p (miR-101-5p) in growth and metastasis cervical cancer.The levels miR-101-5p chemokine (C-X-C motif) ligand 6 (CXCL6) cancer tissues cells were detected using quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) assay. proliferation, colony formation, migration, invasion assays conducted transfected cell. expression CXCL6 was measured by immunoblotting Xenograft model constructed reveal precise cell...
Background: The spinal cord expresses brain-derived neurotrophic factor precursor (proBDNF) and its receptor pan neurotrophin 75 (p75 NTR ). However, the role of proBDNF signaling in pathogenesis inflammatory pain remains unknown. Methods: Rats were locally injected with complete Freund's adjuvant (CFA) to induce pain. signal expression was detected by double-labeled immunofluorescence. ProBDNF protein, p75 extracellular domain -ECD), or monoclonal anti-proBDNF (McAb-proB) administrated...
Background The imbalance of monocyte/macrophage polarization toward the preferential proinflammatory phenotype and a lack normal inflammation resolution are present in acute myocardial infarction (AMI). Our previous study showed that upregulation brain-derived neurotrophic factor precursor (proBDNF) M2-like monocytes may contribute to response Stanford type-A aortic dissection. aimed investigate role proBDNF signaling monocytes/macrophages progress AMI. Methods Results We observed patients...
Purpose: A series of microRNAs (miRNAs) have been identified as associated with the survival patients non-small-cell lung cancer (NSCLC). The aim present study was to explore whether combination these experimentally validated individual miRNA biomarkers could be used further increase their prognostic power in NSCLC. Patients and methods: Based on previously NSCLC miRNAs, gene signatures that discriminate high-risk subgroups poor clinical outcome four expression datasets (GSE13937, GSE16025,...
Platelets have a great ability to modulate immune responses. Monocyte-platelet aggregates (MPAs) are associated with the pathogenesis of cardiac disease. Notably, low preoperative platelet count often indicates poor postoperative recovery following acute aortic dissection (AAD). The functions platelets and MPAs in AAD, however, remain poorly understood. We found that, despite decreased counts, were also activated AAD patients, significant alterations immune-modulating mediators. Of interest,...
Big data technologies have proliferated since the dawn of cloud-computing era. Traditional storage, extraction, transformation, and analysis thus become unsuitable for large volume, diversity, high processing speed, low value density big in medical strategies, which require development novel application technologies. In this regard, we investigated most recent platform breakthroughs anesthesiology designed an anesthesia decision model based on a cloud system storing analyzing massive amounts...