A5049801201- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Connective tissue disorders research
- Vascular Procedures and Complications
- Diabetic Foot Ulcer Assessment and Management
- Diagnosis and Treatment of Venous Diseases
- Cardiac Valve Diseases and Treatments
- Central Venous Catheters and Hemodialysis
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Health, Environment, Cognitive Aging
- Dermatologic Treatments and Research
- Cardiovascular Health and Disease Prevention
- Pressure Ulcer Prevention and Management
- Acute Ischemic Stroke Management
- Pain Management and Treatment
- Cardiovascular Health and Risk Factors
- Tracheal and airway disorders
- Cardiac Structural Anomalies and Repair
- Genetics and Physical Performance
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
University of Pennsylvania
2023-2025
Hospital of the University of Pennsylvania
2021-2024
Philadelphia University
2023
University of Pennsylvania Health System
2023
Pennsylvania Hospital
2023
Georgetown University
2018-2021
MedStar Georgetown University Hospital
2020
Importance: Carotid stenosis, which is atherosclerotic narrowing of the extracranial carotid arteries, an important risk factor for ischemic stroke. The prevalence asymptomatic stenosis generally low, with moderate and severe present in up to ~6% ~2% population, respectively. Prior studies have been small, factors severity incompletely described. We sought leverage rich electronic health record data within Veterans Health Administration assess at population level. Objective: Develop validate...
Background: Thoracic aortic aneurysm and dissection (TAAD) can have catastrophic health consequences. Eleven genes strong or definitive evidence for causing hereditary TAAD (HTAAD). However, patients are seldom tested rare pathogenic (P) likely (LP) variants in these HTAAD absent a family history, little is known about either their prevalence the general population associated risk. Furthermore, degree to which common genetic variation with modifies variant pathogenicity unknown. Methods:...
Thoracic aortic dissection is a life-threatening condition that often occurs in the presence of dilation. However, currently there are limited clinical risk factors beyond diameter (AoD) used to determine individual-level risk. The purpose this study was whether common variant genetics can be improve identification individuals most at for dissection. A genome-wide association (GWAS)-by-subtraction performed characterize diameter-independent thoracic by subtracting GWAS AoD from aneurysm and...
Background: Thoracic aortic aneurysm and dissection (TAAD) can have catastrophic health consequences. Eleven genes strong or definitive evidence for causing hereditary TAAD (HTAAD). However, patients are seldom tested rare pathogenic (P) likely (LP) variants in these HTAAD genes, little is known about their prevalence the general population. The degree to which common genetic variation associated with modifies variant pathogenicity unknown. Methods: Penn Medicine Biobank (PMBB) participants...
Abstract Background Thoracic aortic dissection is a life-threatening condition that often occurs in the presence of dilation. Despite known association between ascending diameter (AscAoD) and risk, predicting risk remains challenging. Objectives Determine whether common variant genetics can be used to improve identification individuals most at for dissection. Methods A genome wide study (GWAS)-by-subtraction was performed characterize diameter-independent thoracic by subtracting GWAS (AoD)...
BACKGROUND: Ascending thoracic aortic dilation is a complex heritable trait that involves modifiable and nonmodifiable risk factors. Polygenic scores (PGS) are increasingly used to assess for diseases. The degree which PGS can improve diameter prediction in diverse populations unknown. Presently, we tested whether adding clinical algorithms improves performance biobank. METHODS: analytic cohort comprised 6235 Penn Medicine Biobank participants with available echocardiography data linked...
Abstract Background Ascending thoracic aortic dilation is a complex trait that involves modifiable and non-modifiable risk factors can lead to aneurysm dissection. Clinical have been shown predict ascending diameter. Polygenic scores (PGS) are increasingly used assess clinical for multifactorial diseases. The degree which PGS improve diameter prediction not known. In this study we tested the extent addition of algorithms improves Methods patient cohort comprised 6,790 Penn Medicine Biobank...
Objective: Sedentary lifestyle with minimal physical activity is a well-established risk factor for poor metabolic health outcomes. Atherosclerotic cardiovascular diseases (ASCVD) are often thought to be associated inactivity, although observational studies may limited by residual confounding which makes causal inference challenging. Mendelian Randomization (MR) method leverages the naturally random allocation of genetic variants as natural experiment, permitting inference. To better...
Background: Ascending thoracic aortic dilation is a complex trait that involves modifiable and non-modifiable risk factors can lead to aneurysm dissection. Clinical have been shown predict ascending diameter. Polygenic scores (PRS) are increasingly used assess clinical for multifactorial diseases. The degree which PRS improves diameter prediction not known. In this study we tested the extent addition of algorithms Methods: Training validation cohorts comprised 6,790 Penn Medicine Biobank...