A5006924088- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- Molecular Biology Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Polyomavirus and related diseases
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Cancer-related molecular mechanisms research
- Appendicitis Diagnosis and Management
- Cutaneous Melanoma Detection and Management
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Congenital Anomalies and Fetal Surgery
- Hematological disorders and diagnostics
- Cell Adhesion Molecules Research
- Intraperitoneal and Appendiceal Malignancies
- Infectious Disease Case Reports and Treatments
- Cervical Cancer and HPV Research
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
Kantonsspital Baselland
2003-2024
University of Zurich
2020
Hospital Base
2016
Theological Seminary Bienenberg
2000-2013
Praxis
2009
Psychiatry Baselland
2006
University of Basel
1999-2003
Cancer Genetics (United States)
1999-2001
National Human Genome Research Institute
1999-2001
National Institutes of Health
1999-2001
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly evolved into a sweeping pandemic. Its major manifestation is in the tract, and general extent of organ involvement microscopic changes lungs remain insufficiently characterised. Autopsies are essential to elucidate COVID-19-associated alterations.This article reports autopsy findings 21 COVID-19 patients hospitalised at University Hospital Basel Cantonal Baselland,...
Abstract Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute syndrome coronavirus 2 (SARS-CoV-2), which has grown to worldwide pandemic with substantial mortality. Immune mediated damage been proposed as pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles post mortem ( n = 34 tissues from 16 patients) normal lung 9 6 patients). Two distinct...
<h3>Background</h3> Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) have been recently approved for treatment of patients with metastatic melanoma non-small lung cancer (NSCLC). Despite important clinical benefits, these therapies are associated a diverse spectrum immune-related adverse events (irAEs) that typically transient, but occasionally severe or even fatal. <h3>Case presentation</h3> This autopsy case...
BACKGROUND: The molecular mechanisms underlying the progression of prostate cancer during hormonal therapy have remained poorly understood. In this study, we developed a new strategy for identification differentially expressed genes in hormone-refractory human by use combination complementary DNA (cDNA) and tissue microarray technologies. METHODS: Differences gene expression between CWR22R xenografts (human transplanted into nude mice) xenograft parental, hormone-sensitive CWR22 strain were...
The ANX7 gene is located on human chromosome 10q21, a site long hypothesized to harbor tumor suppressor gene(s) (TSG) associated with prostate and other cancers. To test whether might be candidate TSG, we examined the ANX7- dependent suppression of cell growth, stage-specific expression in 301 specimens tissue microarray, loss heterozygosity (LOH) microsatellite markers at or near locus. Here report that proliferation colony formation are markedly reduced when wild-type transfected into two...
Aims : Programmed death-1 (PD-1) is expressed by germinal center-associated helper T-cells and acts as a negative regulator of the immune system. PD-1 encountered on tumor cells angioimmunoblastic T-cell lymphoma postulated diagnostic marker in chronic lymphocytic leukemia (CLL/SLL). Recent data suggest prognostic importance follicular (FL). We assessed potential B-cell lymphomas. Methods Distribution PD-1+ lymphocytes lymphomas was studied 403 cases. Correlation with known biologic clinical...
Programmed death-1 (PD-1) is expressed by germinal center-associated helper T-cells and acts as a negative regulator of the immune system. PD-1 encountered on tumor cells angioimmunoblastic T-cell lymphoma postulated diagnostic marker in chronic lymphocytic leukemia (CLL/SLL). Recent data suggest prognostic importance follicular (FL). We assessed potential B-cell lymphomas.Distribution PD-1+ lymphocytes lymphomas was studied 403 cases. Correlation with known biologic clinical key performed....
Aims Immune checkpoint inhibitors have become a successful treatment in metastatic melanoma. The high response rates subset of patients suggest that sensitive companion diagnostic test is required. predictive value programmed death ligand 1 ( PD ‐L1) staining melanoma has been questioned due to inconsistent correlation with clinical outcome. Whether this irrelevance ‐L1 expression or inaccurate assessment techniques remains unclear. aim study was develop standardised digital protocol for the...
Objective. Very recently it has been shown that hyperbilirubinemia is a specific predictor of perforation in acute appendicitis. We compared the diagnostic importance bilirubin, C-reactive protein (CRP), leukocyte count and age as markers Material methods. A two-center retrospective cohort study was completed. Patients with appendicitis (n = 725) were divided into two groups, group 155) B without 570). Results. In an elevated CRP (> 5 mg/l) measured 98% cases versus 72.5% B....
Helicobacter-negative gastritis has been increasingly reported. Molecular techniques as the polymerase chain reaction (PCR) may detect bacterial DNA in histologically negative gastritis.To evaluate of Helicobacter PCR gastric biopsies for daily diagnostics gastritis.Over a 5-year period, routine with chronic reminiscent infection, but by histology, were tested using H. pylori specific PCR. Subsequently, PCR-negative samples re-evaluated other species.Of 9184 biopsies, 339 (3.7%)...
Background DNA sequence amplifications are involved in the progression of many tumor types, and have also been found advanced prostate cancer. The aim this study was to detect new loci Methods Comparative genomic hybridization (CGH) used for whole genome screening copy number alterations 27 cancers. Results most prevalent changes were losses 8p, 13q (52%, each), 6q (48%), 18q (37%), 5q (30%), 2q, 4q 16q (26%, gains 8q Xq (40%), Xp (26%). In addition, 16 high-level found. These included Xq12...
Urinary cytology is limited by high interobserver variability in the evaluation of cells with little atypia. We set up an online quiz on urinary and tested performance 246 international participants. The consisted still images 42 specimens equivocal morphologic features 10 control cases unequivocal cytologic diagnosis. nature 292 had been verified multitarget fluorescence situ hybridization addition to information obtained cystoscopy, clinical follow up, and/or histologic examination....
Urinary cytology is limited by high interobserver variability in the evaluation of cells with little atypia. We set up an online quiz on urinary and tested performance 246 international participants. The consisted still images 42 specimens equivocal morphologic features 10 control cases unequivocal cytologic diagnosis. nature 292 had been verified multitarget fluorescence situ hybridization addition to information obtained cystoscopy, clinical follow-up, and/or histologic examination....
Abstract The sirenomelia sequence with fusion, rotation, hypotrophy or atrophy of the lower limbs in combination severe urogenital and gastrointestinal malformations is a rare usually lethal disorder. We present case 28‐year‐old woman, who was referred to our department because an intraabdominal cystic structure 9th week gestation. Subsequent scans confirmed diagnosis fusion extremities without bones according Stocker I classification. size cyst decreased during follow‐up. After counseling,...
Dermatologic toxicity is an important adverse effect of immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 receptor (PD-1) or PD ligand (PD-L1). Skin most commonly includes a maculopapular erythematous rash pruritus. Rarely life threatening complications such as Steven's Johnson syndrome toxic epidermal necrolysis may occur.Here we report the uncommon event drug-induced transient acantholytic dermatosis (Grover's disease)...
We identified a novel human circovirus in an immunocompromised 66-year-old woman with sudden onset of self-limiting hepatitis. detected 1 (HCirV-1) transcripts hepatocytes and the HCirV-1 genome long-term patient's blood, stool, urine. is emerging pathogen that persists susceptible patients.
Studies of Merkel cell polyomavirus (MCPyV) in nonmelanoma skin cancers (NMSC) other than carcinoma (MCC) produced controversial results. Therefore, we studied the prevalence MCPyV basal (BCC) and squamous (SCC).Tissue specimens were analyzed for presence DNA by conventional polymerase chain reaction (PCR). Expression large T protein was determined immunohistochemistry.MCPyV frequently detected PCR, 36 88 BCCs, 21 75 SCCs 10 47 normal samples. In BCC, a significant difference detection rate...
Coronavirus disease 2019 (COVID-19) mortality can be estimated based on reliable data. Variable testing procedures and heterogeneous course suggest that a substantial number of COVID-19 deaths is undetected. To address this question, we screened an unselected autopsy cohort for the presence SARS-CoV-2 panel common respiratory pathogens. Lung tissues from 62 consecutive autopsies, conducted during first second pandemic waves in Switzerland, were analyzed bacterial, viral fungal pathogens...