A5100638429- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Diagnosis and Treatment of Venous Diseases
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Venous Thromboembolism Diagnosis and Management
- Systemic Sclerosis and Related Diseases
- Ginkgo biloba and Cashew Applications
- Radiomics and Machine Learning in Medical Imaging
- Cell Adhesion Molecules Research
- Neuroscience of respiration and sleep
- Tuberculosis Research and Epidemiology
- Multiple Myeloma Research and Treatments
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Cardiac pacing and defibrillation studies
- Metal-Organic Frameworks: Synthesis and Applications
- Drug Transport and Resistance Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Neonatal Respiratory Health Research
- Gastroesophageal reflux and treatments
- Autophagy in Disease and Therapy
- Nutritional Studies and Diet
Fudan University
2017-2025
Sun Yat-sen University
2018-2025
Zhongshan Hospital
2017-2025
The First Affiliated Hospital, Sun Yat-sen University
2018-2025
Air Force Medical University
2023-2025
Zhejiang University
2002-2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
First Affiliated Hospital of Wenzhou Medical University
2023
Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region
2023
Metagenomic next-generation sequencing (mNGS) was suggested to potentially replace traditional microbiological methodology because of its comprehensiveness. However, clinical experience with application the test is relatively limited. From April 2017 December 2017, 511 specimens were collected, and their retrospective diagnoses classified into infectious disease (347 [67.9%]), noninfectious (119 [23.3%]), unknown cases (45 [8.8%]). The diagnostic performance pathogens compared between mNGS...
Over 5,488,000 cases of coronavirus disease-19 (COVID-19) have been reported since December 2019. We aim to explore risk factors associated with mortality in COVID-19 patients and assess the use D-dimer as a biomarker for disease severity clinical outcome.We retrospectively analyzed clinical, laboratory, radiological characteristics 248 consecutive Renmin Hospital Wuhan University, Wuhan, China from January 28 March 08, 2020. Univariable multivariable logistic regression methods were used...
T lymphopenia, occurring in the early phase of sepsis response to systemic inflammation, is commonly associated with morbidity and mortality septic infections. We have previously shown that a sufficient number cells required constrain Toll-like receptors (TLRs) mediated hyperinflammation. However, underlying mechanisms remains unsolved. Herein, we unveil CD4+ engage MHC II macrophages downregulate TLR pro-inflammatory signaling. show further direct contact between CD4 molecule or ectodomain...
To evaluate the diagnostic accuracy of metagenomic next-generation sequencing (mNGS) for active tuberculosis (TB).We retrospectively collected 820 samples at Zhongshan Hospital, Fudan University in Shanghai, China, between 1 April 2017 and 31 March 2018. They were classified into TB cases (125, 15.2%) NOT (695, 84.8%) according to clinical diagnosis. Specimens evaluated by a regular microbiological assay mNGS performed parallel.Sixty-one confirmed 64 included. The overall sensitivity was...
This article was to summarize the treatment course and prognosis of immunocompetent immunocompromised patients with pulmonary cryptococcal infections analyse relevant factors. The chisquared test used for differences in categorical variables, independent samples t compare continuous variables. Multivariable analyses using Cox proportional hazards model were estimate effect prognostic factors on time improvement time. A total 243 included analysis. Immunocompetent diffuse imaging infiltrates...
ABSTRACT Aims Efgartigimod, a first‐in‐class neonatal Fc receptor antagonist, is approved for generalized myasthenia gravis (gMG). Its safety and efficacy across MG subtypes remain unclear. Methods This single‐center real‐world study (September 2023–July 2024) analyzed patients from an registry in China. The primary outcome the mean MG‐ADL score changes baseline at weeks 4, 8, 12, via estimating equations. Safety was assessed by adverse events. Results Among 77 (mean age 56.1 ± 15.2 years;...
BACKGROUND. Computer-aided diagnosis (CAD) systems for breast ultrasound interpretation have been primarily evaluated at tertiary and/or urban medical centers by radiologists with expertise. OBJECTIVE. The purpose of this study was to evaluate the usefulness deep learning–based CAD software on diagnostic performance without expertise secondary or rural hospitals in differentiation benign and malignant lesions measuring up 2.0 cm ultrasound. METHODS. This prospective included patients...
As the primary cause for chronic pain and disability in elderly individuals, osteoarthritis (OA) is one of fastest-growing diseases due to aging world population. To date, impact microenvironmental changes on pathogenesis OA remains poorly understood, greatly hindering development effective therapeutic approaches against OA. In this study, we profiled differential metabolites synovial fluid from patients identified downregulation vitamin B1 (VB1) as a metabolic feature microenvironment....
Friedreich's ataxia (FA) is an autosomal recessive neurodegenerative disorder, which results primarily from reduced expression of the mitochondrial protein frataxin. FA has estimated prevalence one in 50,000 population, making it most common hereditary ataxia. Paradoxically, mortality arises frequently cardiomyopathy and cardiac failure rather than neurological effects. Decreased high-density lipoprotein (HDL) apolipoprotein A-I (ApoA-l) levels general population are associated with...
Presently, curcumin derivatives had been paid more attention in view of their high bioavailability or water solubility, which herein possibly replaced the for functional applications future. Here, one novel chemically synthesized derivative, ZYX01, was used to identify anti-proliferation activity human non-small lung cancer cells A549 and its anti-proliferative mechanism. Our study showed that ZYX01 could induce autophagic death by morphological observation, MTT assay, acridine orange...
Abstract Background The consequence of cessation biventricular pacing in super‐responders cardiac resynchronization therapy (CRT) has not been fully investigated. Methods In this prospective, single‐blinded clinical trial, 21 were randomly assigned to the ceased (CeP, 11 patients) group or continued (CoP, 10 group. Patients randomized CeP underwent pacing. New York Heart Association (NYHA) class, quality life (QOL) assessed with Minnesota questionnaire, 6‐minute walking distance (6MWD), left...
Purpose: To establish a new rat model, the pathogenesis of which is closer to clinical occurrence chronic obstructive jaundice with liver fibrosis. Methods: 90 SD rats were randomly divided into 3 groups. Group A common bile duct ligation, group B injection compont and C saline. The serum three groups was extracted, function detected by ELISA. HE staining, Masson staining immunohistochemistry used detect pathology. Results: showed fluctuant development jaundice, degree reached peak at 2...