In the current work, synergy between natural compounds and conventional chemotherapeutic drugs is comprehensively reviewed in light of preclinical research findings. The prognosis for lung cancer patients poor, with a 5-year survival rate 18.1%. use combination has gained significant attention as potential novel approach treatment cancer. present work highlights importance finding more effective therapies to increase rates. Chemotherapy primary option but it limitations such reduced...

Lung cancer (LC) represents one of the most prevalent health issues globally and is a leading cause tumor-related mortality. Despite being attractive compounds plant origin due to its numerous biological properties, therapeutic applications rutin (RUT) are limited by disadvantageous pharmacokinetics. Thus, present study aimed evaluate in vitro application two RUT fatty acids bioconjugates, oleate (RUT-O) linoleate (RUT-L), as potential improved RUT-based chemotherapeutics non-small cell lung...

Despite its rarity, cutaneous melanoma (CM) represents the deadliest skin cancer with a high mortality rate, an incidence on rise, and limited therapeutic options at present. Melanin is polymeric pigment naturally produced within melanocytes CM cells that gained noteworthy attention due to pharmacological properties, potential for design of nanoplatforms biomedical applications. Up date, utilization melanin-like nanoparticles (MEL-NPs) in treatment has been well-documented, although their...

Over the past several decades, dental health products containing fluoride have been widely employed to mitigate tooth decay and promote oral hygiene. However, concerns regarding potential toxicological repercussions of exposure incited continuous scientific inquiry. The current study investigated cytotoxicity sodium (NaF) xylitol (Xyl), both individually in combination, utilizing human keratinocyte (HaCaT) osteosarcoma (SAOS-2) cell lines. In HaCaT cells, NaF decreased proliferation a...

Colorectal cancer (CRC) is a heterogenous pathology with high incidence and mortality rates globally, but it also preventable so finding the most promising candidates (natural compounds or repurposed drugs) to be chemopreventive alternatives has become topic of interest in recent years. The present work aims elucidate potential effects combination between genistein (GEN), an isoflavone natural origin, aspirin (ASA) CRC prevention/treatment by performing vitro evaluation human colorectal...

Chlorhexidine (CHX) represents one of the most commonly used antiseptics in dentistry and other medical–pharmaceutical fields due to its broad-spectrum antimicrobial activity. However, potential toxic events arising from common use practice has become a subject increasing concern. Thus, present study was designed investigate toxicity CHX digluconate at concentrations covering antibacterial properties (0.0002–0.2%) HGF primary gingival fibroblasts, HaCaT immortalized human keratinocytes, JB6...

Aspartame (ASP), an artificial sweetener abundantly consumed in recent years array of dietary products, has raised some concerns terms toxicity, and it was even suggested a link with the risk carcinogenesis (colorectal cancer), though present scientific data are rather inconclusive. This study aims at investigating potential role aspartame colorectal cancer by suggesting two experimental approaches: (i) vitro cytotoxicity screening HT-29 human carcinoma cells based on cell viability (Alamar...

Rutin (Rut) is a natural flavonol, well-known for its broad-spectrum of therapeutic effects, including antioxidant and antitumoral activities; still, it has reduced clinical outcome due to limited solubility in aqueous solutions. To overcome this drawback, study proposes novel formulation rutin as proniosomal gel cutaneous applications. The was prepared by coacervation phase-separation method complies with the standard requirements terms particle size (140.5 ± 2.56 nm), zeta potential...

Malignant melanoma represents the deadliest type of skin cancer with narrow treatment options in advanced stages. Herbal constituents possessing anticancer properties occupy a particular spot research as potential chemotherapeutics. Rutin (RUT) is natural compound exerting antioxidant, antimicrobial, anti-inflammatory, UV-filtering, and SPF-enhancing activities that are beneficial to skin; however, its effect an anti-melanoma agent less investigated. The current study focused on assessing...

Oral contraceptives (OCs) are widely used due to their efficiency in preventing unplanned pregnancies and treating several human illnesses. Despite medical value, the toxicity of OCs remains a public concern. Previous studies indicate carcinogenic potential synthetic sex hormones link development progression hormone-dependent malignancies such as breast cancer. However, little is known about influence on evolution triple-negative carcinoma (TNBC), malignancy defined by absence estrogen,...

Rutin (RUT) is considered one the most attractive flavonoids from a therapeutic perspective due to its multispectral pharmacological activities including antiradical, anti-inflammatory, antiproliferative, and antimetastatic among others. Still, this compound presents low bioavailability what narrows clinical applications. To overcome inconvenience, current paper was focused on synthesis, characterization, toxicological assessment of two RUT bioconjugates obtained by enzymatic esterification...

Background and Objectives: Cutaneous melanoma (CM) poses a continuous challenge in oncology due to the developing resistance available treatments. Doxorubicin (DOX) is noted as one of most effective chemotherapeutics, although associated toxicity limit its use CM treatment. Consequently, DOX has become promising candidate for combination therapies targeting this neoplasm. Genistein (GEN) gathered significant attention anti-neoplastic properties ability enhance effects against several...

Cancer is a significant health problem worldwide; consequently, new therapeutic alternatives are being investigated, including those found in the vegetable kingdom. Eugenol (Eug) has attracted attention for its properties, especially stomatology. The purpose of this study was to investigate cytotoxicity Eug, vitro, on osteosarcoma (SAOS-2) and oropharyngeal squamous cancer (Detroit-562) cells, as well potential irritant effect ovo at level chorioallantoic membrane (CAM). data obtained...

Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancer types with current deficient and aggressive treatment options, but various studied alternative therapies are able to efficiently contribute its management. Essential oils (EOs) contain valuable compounds, antibacterial, anti-inflammatory, anticancer properties, which might serve as effective solutions in CRC prophylaxis or treatment. The aim present work was evaluate phytochemical composition vitro biological activity...

Malignant melanoma (MM) represents the most life-threatening skin cancer worldwide, with a narrow and inefficient chemotherapeutic arsenal available in advanced disease stages. Lupeol (LUP) is triterpenoid-type phytochemical possessing broad spectrum of pharmacological properties, including potent anticancer effect against several neoplasms (e.g., colorectal, lung, liver). However, its potential as an anti-melanoma agent has been investigated to lesser extent. The current study focused on...

Solar ultraviolet radiation (UVR) is responsible for the development of many skin diseases, including malignant melanoma (MM). This study assessed phototoxic effects UVA, and UVB radiations on healthy pathologic cells by evaluating behavior human keratinocytes (HaCaT) MM (A375) at 24 h post-irradiation. The main results showed that UVA 10 J/cm2 exerted no cytotoxicity HaCaT A375 cells, while 0.5 significantly reduced cell viability confluence, induced shrinkage rounding, generated nuclear...

Recent scientific evidence suggests a link between epigenetic changes (DNA methylation) and tumorigenesis. Moreover, potential carcinogenic mechanism of cadmium was associated with in DNA methylation. In this study we investigated the impact CdCl₂ CuSO₄ aqueous solutions on methylation HT‑29 cells by quantifying methyltransferase (DNMT1, DNMT3A DNMT3B) mRNA expression. Furthermore, also studied cytotoxic anti‑migratory these substances. The results showed dose‑dependent...

Melissa officinalis is a medicinal herb with an extensive pharmacological profile that has been proven to have beneficial effects in oral and gastrointestinal disorders. However, the of this plant oral, pharyngeal, colorectal malignancies, types cancer increased incidence recent years, are less investigated. The present study aims evaluate total extract for potential benefits pharynx carcinoma. LC-MS MO (MOte) indicated rich content polyphenols, data support potent antioxidant capacity...

The skin integrity is essential due to its pivotal role as a biological barrier against external noxious factors. Pentacyclic triterpenes stand valuable plant-derived natural compounds in the treatment of injuries their anti-inflammatory, antioxidant, antimicrobial, and healing properties. Consequently, primary aim current investigation was development well physicochemical pharmaco-toxicological characterization betulin- lupeol-based oleogels (Bet OG Lup OG) for topical application injuries....