A5007253077- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- CAR-T cell therapy research
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Screening and Detection
- Nonmelanoma Skin Cancer Studies
- Colorectal Cancer Treatments and Studies
- Virus-based gene therapy research
- Anorectal Disease Treatments and Outcomes
- Gastric Cancer Management and Outcomes
- Radiopharmaceutical Chemistry and Applications
- Sarcoma Diagnosis and Treatment
- Heat shock proteins research
- T-cell and B-cell Immunology
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Ocular Oncology and Treatments
- Cutaneous lymphoproliferative disorders research
Fondazione IRCCS Istituto Nazionale dei Tumori
2010-2024
Colorectal Surgical Associates
2018
Creative Research Enterprises (United States)
2016
Ospedale San Giuseppe
2007
Melanoma Institute Australia
2004
Tumori Foundation
1994-2003
Sigma Tau (Italy)
2002
European Institute of Oncology
2002
Centro di Riferimento Oncologico
2002
National Cancer Institute
1998-2001
PURPOSE: To determine the immunogenicity and antitumor activity of a vaccine consisting autologous, tumor-derived heat shock protein gp96-peptide complexes (HSPPC-96, Oncophage; Antigenics, Inc, Woburn, MA) in metastatic (American Joint Committee on Cancer stage IV) melanoma patients. PATIENTS AND METHODS: Sixty-four patients had surgical resection tissue required for production, 42 were able to receive vaccine, 39 assessable after one cycle vaccination (four weekly injections). In 21...
Human natural regulatory CD4(+) T cells comprise 5-10% of peripheral CD4(+)T cells. They constitutively express the IL-2Ralpha-chain (CD25) and nuclear transcription Foxp3. These are heterogeneous contain discrete subsets with distinct phenotypes functions. Studies in mice report that LAG-3 has a complex role cell homeostasis is expressed CD4(+)CD25(+) In this study, we explored expression human found identifies subset CD4(+)CD25(high)Foxp3(+) This CD4(+)CD25(high)Foxp3(+)LAG-3(+) population...
Colorectal carcinoma (CRC) is one of the most common tumors in adults, but extremely rare young age. This study retrospectively reports on a group 27 patients <30 years age, and particularly 7 cases <18 old, treated at Istituto Nazionale Tumori, Milan, Italy, between 1985 2005.Among children/adolescents (age 9-18, median 12 years), 5/7 had unfavorable CRC histotypes (poorly differentiated or mucinous adenocarcinoma) all advanced disease onset. Initial surgical resection was complete cases,...
PURPOSE: This study was designed to evaluate the frequency of microscopic distal intramural spread in rectal adenocarcinoma and its correlation other histopathologic prognostic factors. METHODS: We examined 55 patients with adenocarcinomas lower one-third rectum measured extent submucosa and/or muscular layer comparison Dukes Stage, diameter tumor, distance margin resection from depth infiltration into perirectal adipose tissue, nodal status, neoplastic lymphatic vessels, blood nervous...
BACKGROUND The objective of this study was to evaluate the neurologic and quality life impact low dose adjuvant interferon (IFN)-α immunotherapy in patients with malignant melanoma metastatic regional lymph nodes after radical surgery. METHODS One hundred thirteen were randomized receive IFN-α, 3 x 106 IU three times weekly by subcutaneous injection for 36 months or until recurrence (IFN group), act as controls (CTR group). Seventy-five these (66%) entered toxicity underwent formal...
Abstract Tumor cells have been shown recently to escape immune recognition by developing resistance Fas-mediated apoptosis and acquiring expression of Fas ligand (FasL) molecule that they may use for eliminating activated Fas+ lymphocytes. In this study, we report tumor-specific T lymphocytes isolated from tumor lesions repeated in vitro TCR stimulation with relevant Ags (mostly represented normal self proteins, such as MART-1/Melan A gp100) can develop strategies overcoming these...
We have immunized advanced melanoma patients with a HLA-A2-compatible human line genetically modified to release interleukin-2 (IL-2), elicit or increase T cell-mediated anti-melanoma response that may affect distant lesions. Twelve stage-IV were injected subcutaneously at days 1, 13, 26, and 55 IL-2 gene-transduced irradiated cells doses of 5 15 × 107 cells. Both local systemic toxicities mild, consisting transient erythema the vaccination site; fever occurred in minority patients. Three...
The question of whether manual dissection when searching for metastatic lymph nodes from rectal cancer (less than 5 mm) is a reliable method remains controversial.We examined 50 consecutive cases primary adenocarcinoma the rectum treated with sphincter-sparing total resection, mesorectum excision, and coloanal anastomosis. We used detection nodes.One thousand seven hundred ninety-three were found (mean, 36 per patient). One seventy-four contained metastases. Seventy-nine (45.4%) affected...
Abstract Nine different human melanomas and 16 clones, isolated from 2 of them, were characterized for susceptibility to rIL1‐β, rIL4‐, rTNF‐α‐ rIFN‐γ‐mediated effects on proliferation surface expression class‐II HLA (DR DP), ICAM‐1 LFA‐3 molecules 3 tumor‐associated antigens (recognized by MAb 763.74T, 149.53 R24). In spite marked inter‐ intra‐tumor heterogeneity the each cytokine, most frequent upregulation was induced rIFN‐γ adhesion rIFN‐γ, rTNF‐α rlL1‐β, while often down‐modulated...
Utilization of alpha-tumor necrosis factor (alpha-TNF) in clinical practice is limited by severe general side effects. Very promising results with low toxicity were reported administration alpha-TNF isolation perfusion extracorporeal circulation.From December 1991 to November 1992, 14 patients underwent (2-4 mg, total dose), gamma-interferon (1.5 x 10(6) IU), and melphalan (10 mg/l/perfused limb). Twelve presented in-transit metastases the limbs, one patient, a clear cell sarcoma hand, wide...