A5050740168- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Esophageal and GI Pathology
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Microscopic Colitis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Celiac Disease Research and Management
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Inflammatory Bowel Disease
- Gastroesophageal reflux and treatments
- Vaccine Coverage and Hesitancy
- Pediatric Hepatobiliary Diseases and Treatments
- Diet, Metabolism, and Disease
- Genetic factors in colorectal cancer
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Cancer, Hypoxia, and Metabolism
Golestan University
2016-2025
Golestan University of Medical Sciences
2016-2025
Princess Alexandra Hospital
2025
The University of Queensland
2025
Masih Daneshvari Hospital
2022
Shahid Beheshti University of Medical Sciences
2009-2022
Mashhad University of Medical Sciences
2019-2021
Currently no effective antiviral therapy has been found to treat COVID-19. The aim of this trial was assess if the addition sofosbuvir and daclatasvir improved clinical outcomes in patients with moderate or severe COVID-19.This an open-label, multicentre, randomized controlled adults COVID-19 admitted four university hospitals Iran. Patients were into a treatment arm receiving plus standard care, control care alone. primary endpoint recovery within 14 days treatment. study is registered...
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the cause of COVID-19 pandemic and increased mortality, especially among elderly patients those who have severe complications, such as chronic pulmonary obstruction, hypertension, diabetes, cancer. Nutrition, micronutrients, plays an important role in reducing mortality complications from because micronutrients strengthen our immune system nutritional status factor that affects outcome with COVID-19. Among selenium has effect on...
Oesophageal squamous cell carcinoma (ESCC) is a fatal disease with 5-year survival rates of <5% in Northern Iran. dysplasia (ESD) the precursor histologic lesion ESCC. This pilot study was conducted to assess feasibility, safety, and acceptability non-endoscopic cytological examination oesophagus provide initial data on accuracy atypia for identifying patients ESD this very-high-risk area.Randomly selected asymptomatic participants Golestan Cohort Study were recruited. A specimen taken using...
Tooth loss and periodontal disease have been associated with several cancers, poor oral health may be an important risk factor for upper gastrointestinal (UGI, i.e., esophageal gastric) cancers. We assessed the relationship between UGI cancers using a large prospective study of over 50,000 adults living in Golestan Province, Iran, high-incidence area these Hazard ratios (HRs) 95% confidence intervals (CI) were estimated association three different measures [frequency tooth brushing; number...
ABSTRACT Background and Aims On March 11, 2020, the World Health Organization declared Coronavirus disease 2019 (COVID‐19) as a pandemic. The spread of Delta variant coronavirus started in June 2021 accounted for fifth peak COVID‐19 Iran July 2021. According to reports from other countries, vaccination protects against severe diseases caused by COVID‐19, including variant. Studies have also shown that provides strong protection SARS‐CoV‐2 infection, COVID‐19‐related hospitalization,...
Introduction: Several factors affect the difficulty, clinical success, and side effects related to endoscopic retrograde cholangiopancreatography (ERCP), of which appearance major papilla is one most important. This study aimed investigate outcomes ERCP in relation morphology. Methods: was performed prospectively on 581 patients undergoing ERCP. During ERCP, endoscopist determined morphology before cannulation. Primary included overall operative success rate post-ERCP pancreatitis (PEP) at...
Non-alcoholic fatty liver disease (NAFLD) as the most common chronic is associated with metabolic disorders including dysregulated lipid and glucose metabolism. There no approved drug treatment for NAFLD; thus, new therapies are needed. We studied antidyslipidemic effects of atorvastatin and/or possibly hepatoprotective flaxseed/ flaxseed oil in a rat model NAFLD. Fifty-six male Wistar rats were divided randomly into seven groups: 1) control, 2) high-fructose diet (HFD), 3) HFD +atorvastatin...
The combination of sofosbuvir and daclatasvir is a potent, pangenotypic regimen suitable for mass-scale hepatitis C treatment, especially in resource-limited countries where newer, expensive combinations are not available. This has been widely tested on genotype 4. However, Phase III trials this other genotypes have cost prohibitive. With the introduction generic, low-cost daclatasvir, large-scale studies now possible.Sofosbuvir at 400 mg 60 were coformulated into fixed-dose (FDC) tablet...
Chronic hepatitis B (CHB) poses treatment challenges, with response and disease outcome often determined by the immune response, particularly mononuclear phagocytes. Monocytes can differentiate into various subpopulations influenced AHR. Statins, known for inflammation modulation, may impact monocyte function via AHR activation. This study explored rosuvastatin (RSV)’s effects on subtypes, inflammatory markers, in CHB patients. Fifteen patients were randomly assigned to receive either 20 mg...
We evaluated the immune response to neonatal HBV immunization in children of infected parents 10-18 years after primary vaccination. Healthy individuals immunized with an infantile course three doses vaccine were tested for persistence anti-HB surface antibody (HBsAb). Those HBsAb level <10 IU/mL received a booster dose subsequent those without protective titres. concentrations determined 4 weeks each vaccine. The data analysed separately age groups: 10-11, 12-14 and 15-18 old. A total 541...
Many diabetic individuals use prescription and non-prescription opioids opiates. We aimed to investigate the joint effect of diabetes opiate on all-cause cause-specific mortality.
Celiac disease (CD) is a genetically determined autoimmune triggered by gluten consumption. Patients with these conditions have intraepithelial lymphocytosis, crypt hyperplasia, and severe intestinal atrophy. Gluten elimination the only way to reduce this chronic inflammation. The diagnosis of CD usually made analyzing anti-tTG, anti-DGP, or EMA serological tests, it confirmed biopsy duodenum. In people CD, xerostomia dry mouth common complication. This condition causes salivary glands...
Background: Endoscopic retrograde cholangiopancreatography (ERCP) has an important role in the treatment of pancreaticobiliary disorders. Goals: Considering high prevalence and importance postendoscopic pancreatitis (PEP) controversial findings, we aimed to determine effect adding intravenous somatostatin rectal indomethacin on incidence PEP high-risk patients. Study: In this prospective study, 530 patients underwent ERCP during March 2018 February 2019. Patients were randomized into 2...
Helicobacter pylori and Migraine: Is Eradication of Effective in Relief Migraine Headache?
One of the most important complications in inflammatory Bowel Disease (IBD) are musculoskeletal manifestations that reported more than 50% patients.In this study, we aimed to evaluate and radiologic our IBD cross-sectional study on 96 mild-to-moderate patients (76 UC, 18 CD 2 undifferentiated IBD) with mean (SD) age 39.28 (11.42) years, 44 (45.8%) were males 52 (54.2%) females. Patients examined by an expert rheumatologist their symptoms assessed. The system was evaluated Modified Schober...
According to the significance of extraintestinal symptoms in inflammatory bowel disease (IBD) patients and their connection with obesity, we aimed investigate prevalence fatty liver IBD Sayyad Shirazi Hospital Gorgan, Iran, relation anthropometric indicators body image these patients.