A5072175911- Heavy Metal Exposure and Toxicity
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Birth, Development, and Health
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Nutritional Studies and Diet
- Environmental Justice and Health Disparities
- Cancer, Hypoxia, and Metabolism
- Antioxidant Activity and Oxidative Stress
- Obesity, Physical Activity, Diet
- Trace Elements in Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Arsenic contamination and mitigation
- Retinoids in leukemia and cellular processes
- Immunotoxicology and immune responses
- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Radioactivity and Radon Measurements
- Early Childhood Education and Development
- Child and Adolescent Psychosocial and Emotional Development
- Salivary Gland Disorders and Functions
- Breastfeeding Practices and Influences
University of New Mexico
2014-2025
University of Wisconsin–Madison
1992-2009
UW Health University Hospital
1996-2000
University of Edinburgh
1997
Ventura County Medical Center
1996
Versus Arthritis
1996
Loma Linda University
1996
SUMMARY Natural immunity may be involved in controlling viral spread hosts infected with HIV. A panel of γδ T cell receptor-positive lymphocyte clones was isolated from the peripheral blood healthy HIV− donors and tested for anti-HIV cytotoxic responses. Twelve 30 (40%) Vγ9+Vδ2+ clones, but none seven Vδ1+ displayed lytic activity against HIV-infected cells. The Vγ9+/Vδ2+ cells also lysed Daudi However, not all which targets had capacity to lyse Some were investigated potential proliferative...
Intrarectal inoculation of rhesus monkeys with low doses SIV mac led to a prolonged clinical and virological latency that was not observed for high intrarectal or intravenous inoculation. Animals infected intrarectally virus remained negative serum antibody responses at least one year even though they readily transferred naive recipients via transfusion whole blood.
GRAIL (gene related to anergy in lymphocytes) is an ubiquitin-protein isopeptide ligase (E3) ubiquitin necessary for the induction of CD4+ T cell vivo. We have extended our previous studies characterize expression pattern other murine types with a described anergic phenotype. These revealed that increased naturally occurring (thymically derived) CD25+ regulatory cells (mRNA levels 10-fold higher than naive CD25– cells). Further investigation demonstrated Foxp3+ antigen-specific were induced...
Early-life exposure to environmental toxicants can have detrimental effects on children's neurodevelopment. In the current study, we employed a causal modeling framework examine direct effect of specific maternal prenatal exposures infants' neurodevelopment in context co-occurring metals. Maternal metal and select micronutrients' concentrations were assessed using samples collected at time delivery from mothers living across Navajo Nation with community mixtures originating abandoned uranium...
Abstract BACKGROUND The androgen receptor (AR) plays a critical role in prostate cancer development and progression. Therefore, the inhibition of AR function is an established therapeutic intervention. Since expression retained often increased progressive disease, protein down‐regulation promising approach against cancer. We show here that curcumin analog 27 (ca27) down‐regulates several cell lines. METHODS ca27 at low micromolar concentrations was tested for its effect on expression,...
It is known that exposure to As+3 via drinking water causes a disruption of the immune system and significantly compromises response infection. The purpose these studies was assess effects on bone marrow progenitor cell colony formation humoral T-dependent antigen (TDAR) in vivo. In 30 day study, mice were exposed 19, 75, or 300 ppb As+3. There decrease recovery, but not spleen recovery at marrow, altered neither expression CD34+ CD38+ cells, markers early hematopoietic stem nor...
Longitudinal measures of diet spanning pregnancy through adolescence are needed from a large, diverse sample to advance research on the effect early-life nutrition child health. The Environmental influences Child Health Outcomes (ECHO) Program, which includes 69 cohorts,>33,000 pregnancies, and >31,000 children in its first seven-year cycle, provides such data, now publicly available. To describe dietary intake data available ECHO Program as August 31, 2022 (end year 6 Cycle 1) adolescence,...
The synthesis of analogues AcSerLeuAsn[Phe-HEA-Pro]IleValOMe (1, JG-365; where HEA stands for the hydroxyethylamine unit 2), a tight-binding inhibitor HIVP, are reported. Systematic modification P3 and P3' regions inhibitors has led to smaller HIVP that inhibit viral replication in HIV-infected SIV-infected cell cultures. Six aliphatic and/or aromatic derivatives were prepared by replacing residues BocLeuAsn[Phe-HEA-Pro]IleValOMe. Aromatic side chains at gave better than chains. this series...
Background: The financial hardships and social isolation experienced during the COVID-19 pandemic have been found to adversely affect children’s developmental outcomes. While many studies thus far focused on school-aged children pandemic-related impacts their academic skills behavior problems, relatively less is known about associations with development early years. Using a racially economically diverse sample, we examined whether were associated particular focus communication socioemotional...
Preterm birth (PTB), defined as before 37 wk gestation, is associated with hypertension, diabetes, inadequate prenatal care, unemployment or poverty, and metal exposure. Indigenous individuals are more likely to have maternal risk factors PTB compared other populations in the United States; however, role of environmental metals on among pregnant women remains uncertain. Previous research identified associations between individual metals, but there limited investigation mixtures this outcome.
Abstract The androgen receptor (AR) is a steroid hormone which regulates transcription of androgen‐sensitive genes and responsible for the development maintenance male secondary sexual characteristics. Chemicals that interfere with AR activity may lead to pathological conditions in tissues. A variety reporter systems have been developed, driven by promoters, screen chemicals modulate androgenic activity. We developed flexible, high‐throughput transcriptional activation assay, designated...
Tocopherylquinone (TQ), the oxidation product of alpha-tocopherol (AT), is a bioactive molecule with distinct properties from AT. In this study, AT and TQ are investigated for their comparative effects on growth androgenic activity in prostate cancer cells. potently inhibited androgen-responsive cell lines (e.g., LAPC4 LNCaP cells), whereas androgen-independent cells DU145 cells) was not affected by TQ. Due to inhibitory induced cells, anti-androgenic were examined. androgen-induced...
Abstract Proper nutrition during pregnancy is vital to maternal health and fetal development may be challenging for Navajo Nation residents because access affordable healthy foods limited. It has been several decades since reported diet quality was examined on Nation. We present the first study estimate iodine intake use Healthy Eating Index (HEI‐2015) assess among pregnant women in Birth Cohort Study (NBCS). Based dietary data derived from food frequency questionnaires, overall estimated...