Lactoferrin binding protein B (LbpB) is a bi-lobed membrane bound lipoprotein that part of the lactoferrin receptor complex in variety Gram-negative pathogens. Despite high sequence diversity among LbpBs from various strains and species, cluster negatively charged amino acids invariably present protein's C-terminal lobe all species except Moraxella bovis. The function LbpB iron acquisition has yet to be experimentally demonstrated, whereas vitro studies have shown confers protection against...

Bacteria that inhabit the mucosal surfaces of respiratory and genitourinary tracts mammals encounter an iron-deficient environment because iron sequestration by host iron-binding proteins transferrin lactoferrin. Lactoferrin is also present in high concentrations at sites inflammation where cationic, antimicrobial peptide lactoferricin produced proteolysis Several Gram-negative pathogens express a lactoferrin receptor enables bacteria to use as source. The composed integral membrane protein,...

Sodium dichloroisocyanurate (NaDCC) is a chemical agent that acts against microorganisms in manner similar to of sodium hypochlorite by releasing free available chlorine. NaDCC has been approved the WHO for emergency treatment water and US EPA routine water. Previous studies assessing effectiveness implied should have wide array disinfecting effects beyond planktonic cells potable In this study biocidal Pseudomonas aeruginosa different growth modes including biofilms were explored. The data...

Launched in 2014, the RARE Compassion Program is first international educational program to pair medical students with rare disease patients order enhance exposure and comfort diseases. As part of ongoing quality improvement, this study retrospectively reviewed four years participant registration data conduct a evaluation between 2014–2018. During period, there were 334 student participants, representing 67.3% Association American Medical Colleges (AAMC) member schools, 5389 volunteers....

Pathogenic bacteria from the families Neisseriaeceae and Moraxellaceae acquire iron their host using surface receptors that have ability to hijack iron-sequestering proteins transferrin (Tf) lactoferrin (Lf). The process of acquiring Tf has been well-characterized, including role lipoprotein transferrin-binding protein B (TbpB). In contrast, only well-defined for homologue, LbpB, is in its protection against cationic antimicrobial peptides, which mediated by regions present some LbpBs are...

Glycated hemoglobin A1c (HbA1c) is considered the standard of care for testing and monitoring diabetes. Its ability to accurately reflect glycemia, however, imperfect. Hemoglobin variants-mutant forms caused by genetic variation present in 7% population-are known adversely affect HbA1c measurement glycemic control. We report an illustrative case a 64-year-old nondiabetic man with steadily decreasing no symptoms hypoglycemia or concerning family history. Preliminary investigative workup...

A 50-year-old man with a polycystic kidney disease, awoke from sleep unilateral jaw swelling. As demonstrated in the accompanying [figure 1][1], oedema progressed over period of 6 hours to involve his lips and tongue. On involvement tongue development slurred speech, he

A female smoker in her seventies, presented to an emergency department with months of progressive weight loss, 1 week worsening jaundice, pale stools and recent onset episodic abdominal pain. Physical exam was notable for numerous seborrheic keratosis throughout the entire torso, ranging up

Abstract Background Endoscopic ultrasound-guided fine-needle aspiration with Rapid On Site Evaluation (ROSE EUS-FNA) and endoscopic core-needle biopsy (EUS-CNB) are widely used for the diagnosis of pancreatic tumors. There is no known published randomized control trial that compares between two modalities. Given aggressive nature cancer, it crucial to make a prompt in order initiate treatment timely fashion. Aims This study diagnostic performance ROSE EUS-FNA EUS-CNB cancer. Methods A...

Abstract Background Mahvash Syndrome a rare autosomal recessive cause of pancreatic neuroendocrine tumors (pNET) results from inactivation GCCR. Clinically it presents with hyperglucagonemia without glucagonoma syndrome. Since described in 2008 all surviving adult cases have been managed surgically. We describe 2 related medically. Case 1 In 2015 52 year old female history an enlarged pancreas (Aunt 2) presented incidentally identified hypovascular masses while being assessed for back pain....

A 71-year-old male presented to hospital with 3 months of increasing abdominal distention and pain. CT showed large volume ascites gastric wall thickening in the antrum. He had no history significant alcohol use or other risk factors for cirrhosis. underwent paracentesis, litres homogenously bloody fluid was removed. Ascites cytology discohesive malignant cells. Upper endoscopy a 10 cm circumferential mass. Biopsies revealed diagnosis adenocarcinoma. The presence can be startling finding...