A5060751326- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Nicotinic Acetylcholine Receptors Study
- Cholesterol and Lipid Metabolism
- Cell Adhesion Molecules Research
- Diabetes Treatment and Management
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
Case Western Reserve University
2020-2024
University School
2020
Institute of Higher Nervous Activity and Neurophysiology
2019
Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are powerful glycemia-lowering agents, which have systematically been shown to lower cardiovascular events and mortality.These beneficial effects were difficult pinpoint within atherosclerotic plaque due lack of particular specificity such the vascular cells an inadequate understanding GLP-1R expression in atherosclerosis.Here, we hypothesized that direct engagement atherosclerosis by targeted will alleviate inflammation burden,...
Here, we report a nanoparticle-based probe that affords facile cell labeling with cholesterol in efflux (CE) assays. This probe, called ezFlux, was optimized through screening of multiple nanoformulations engineered Förster resonance energy transfer (FRET) reporter. The physicochemical- and bio-similarity ezFlux to standard semi-synthetic acetylated low-density lipoprotein (acLDL) confirmed by testing uptake macrophages, the intracellular route degradation, performance CE A single-step fast...