A5102809206- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Child Nutrition and Water Access
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- Economic and Environmental Valuation
- T-cell and B-cell Immunology
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- vaccines and immunoinformatics approaches
- Global Security and Public Health
- HIV/AIDS Impact and Responses
- Health Systems, Economic Evaluations, Quality of Life
- Global Health Care Issues
- Urban and Rural Development Challenges
- Syphilis Diagnosis and Treatment
- Adolescent Sexual and Reproductive Health
- Immune Cell Function and Interaction
- Global Maternal and Child Health
- Health and Wellbeing Research
- Virology and Viral Diseases
- Vaccine Coverage and Hesitancy
- HIV/AIDS oral health manifestations
- Sex work and related issues
Instituto Nacional de Saúde
2014-2025
London School of Hygiene & Tropical Medicine
2024
World Vision
2024
Centre for Infectious Disease Research in Zambia
2024
Ministry of Health
2019-2024
Karolinska Institutet
2014-2017
Eduardo Mondlane University
2014-2017
Clínica Sagrada Esperança
2016
HIV type 1 (HIV-1) remains a global health concern, with the greatest burden in sub-Saharan Africa. Despite 40 years of research, no vaccine candidate has shown durable and protective efficacy against HIV-1 acquisition. Although pre-exposure prophylaxis groups high vulnerability can be very effective, barriers to its use, such as perceived low acquisition risk, fear stigma, concerns about side-effects, remain. Thus, population-based approach, an vaccine, is needed. The current study aimed...
A total of 1.5 billion people live without basic sanitation. 5-attribute index sanitation-related quality life (SanQoL-5) has been applied in 9 countries. SanQoL-5 attributes and their levels require weighting (valuation), with the resulting ranging from 0 to 1. To date, valuation simple methods such as rank sum, not robust discrete choice experiment (DCE). We aimed value using a DCE urban Mozambique. enrolled 601 adults cities Maputo Dondo, sampling women men equally. The task was which...
Background Clinical laboratory reference values from North American and European populations are currently used in most Africans countries due to the absence of locally derived ranges, despite previous studies reporting significant differences between populations. Our aim was define ranges for both genders 18 24 year-old Mozambicans preparation clinical vaccine trials. Methods A cross-sectional study including 257 volunteers (102 males 155 females) years performedat a youth clinic Maputo,...
Background Prevalence of HIV in Mozambique among individuals aged 15–49 years is 11.5%. The prevalence higher women than men across the country, peaking at ages 25–29 and 35–39 years, respectively. In this study, we aimed determining incidence HIV, Hepatitis B (HBV), syphilis youths. We also characterized a cohort youths for future participation phase I/II vaccine trials. Methods study was conducted youth clinic Maputo Central Hospital from August 2009 to October 2011. Youths both genders...
Objective: One recurrent question is whether an HIV-1 preventive vaccine requires adaptation to geographic and/or ethnicity background. A recent attempt improve the Thai RV144 efficacy in South Africa resulted non-efficacy. The potential reasons for this disappointing outcome are probably multifactorial; role of could not be investigated given trials’ demographics. Design: To assess immune responses induced HIV trials, we considered HVTN 204 trial, which was conducted USA and Africa....
The Janssen Ebola virus (EBOV) vaccine consists of the adenovirus type 26 vector encoding EBOV glycoprotein (GP) (Ad26.ZEBOV) and modified vaccinia Ankara (MVA) GP from EBOV, Sudan virus, Marburg nucleoprotein Tai Forest (MVA-BN-Filo) administered 8 weeks later. We conducted a systems immunology analysis antibody-mediated cellular immune responses induced after two immunizations with either used first. response to vaccination was specific defined by high antibody binding, Fc effector,...
Background: Diarrhoeal disease remains a significant cause of mortality among children under five years age in many countries. Food consumed by young high-burden settings is often contaminated, thereby exposing to foodborne risks. Better understanding food preparation, feeding, and storage practices foods aged 6–24 months can support efforts reduce diarrhoeal disease. A hazard analysis critical control point (HACCP) approach was used determine points (CCPs) that might risk contamination...
Background We evaluated the safety and immunogenicity of (i) an intradermal HIV-DNA regimen given with/without electroporation (EP) as prime (ii) impact boosting with modified vaccinia virus Ankara (HIV-MVA) administered or without subtype C CN54rgp140 envelope protein adjuvanted Glucopyranosyl Lipid A (GLA-AF) in volunteers from Tanzania Mozambique. Methods Healthy HIV-uninfected adults (N = 191) were randomized twice; first to one three priming regimens by needle-free ZetaJet device at...
Abstract Background. 1.5 billion people globally lack access to a basic toilet. Progress on sanitation is primarily measured by types of toilets used. Quality life (QoL) outcomes are valued users but rarely rigorously measured. The Sanitation-related Life (SanQoL-5) index uses five simple questions measure people’s experiences sanitation-related disgust, disease, privacy, shame, and safety. Developed in urban Mozambique based the capability approach welfare economics, it increasingly being...
Abstract Introduction Shared sanitation facilities are used by over 500 million people around the world. Most research evidence indicates that shared conveys higher risk than household for many adverse health outcomes. However, studies often fail to account variation between different types of facilities. As informal housing development outpaces infrastructure, it is imperative understand which components may mitigate risks use. Methods This cross-sectional study determines whether...
We assessed the safety and immunogenicity of HIV-DNA priming using Zetajet™, a needle-free device intradermally followed by intramuscular HIV-MVA boosts, in 24 healthy Mozambicans. Volunteers were randomized to receive three immunizations 600 μg (n = 10; 2 × 0.1 ml) or 1,200 0.2 (3 mg/ml), two boosts 108 pfu HIV-MVA. Four subjects received placebo saline injections. Vaccines injections safe well tolerated with no difference between groups. After immunizations, IFN-γ ELISpot responses Gag...
Shorter prophylactic vaccine schedules may offer more rapid protection against Ebola in resource-limited settings.
Introduction Mozambique continues to have a significant burden of HIV. Developing strategies control the HIV epidemic remains key priority for Mozambican public health community. The primary aim this study was determine prevalence and risk behavior among males females screened vaccine preparedness in Maputo, Mozambique. Methods Male female participants between 18–35 years old were recruited from general community sex worker (FSW) lesbian, gay, bisexual, transgender (LGBT) associations...
Antibody responses that correlated with reduced risk of HIV acquisition in the RV144 efficacy trial were assessed healthy African volunteers who had been primed three times HIV-DNA (subtype A, B, C) and then randomized into two groups; group 1 was boosted twice HIV-MVA (CRF01_AE) 2 same coadministered subtype C envelope (Env) protein (CN54rgp140/GLA-AF). The fine specificity plasma Env-specific antibody mapped after final vaccination using linear peptide microarray technology. Binding IgG...
Background There remains an urgent need for a prophylactic HIV vaccine to control generalised epidemics. PrEP has demonstrated effectiveness of 86% and is recommended by WHO; uptake generally high, but retention disappointing in some settings. The EDCTP2 project PrEPVacc will assess the efficacy two combination regimens (DNA, MVA Env protein/adjuvant) each compared placebo proportion infections averted F/TAF comparison TDF/FTC. A Registration Cohort, recruiting negative volunteers at risk...
PrEP literacy is influenced by many factors including the types of information available and how it interpreted. The level may influence acceptability uptake.We conducted 25 in-depth interviews in a HIV vaccine trial preparedness cohort study. We explored what participants knew about PrEP, sources knowledge much they know PrEP. used framework approach to generate themes for analysis guided Social Ecological Model examined levels using individual interpersonal constructs SEM.We found that...
<title>Abstract</title> Objectives 1.5 billion people live without basic sanitation. A five-attribute index of sanitation-related quality life (SanQoL-5) designed for economic evaluation has now been applied in six countries. After rescaling, scores range 0 (no sanitation capability) to 1 (full capability). To date, SanQoL-5 valuation via simple methods such as rank sum, not robust discrete choice experiment (DCE). We aimed value the using a DCE urban Mozambique. Methods enrolled 601 adults...
Human immunodeficiency virus type 1 (HIV-1) causes impairment of T and B cell responses, which begins during the acute phase infection is not completely restored by antiretroviral treatment. Regulatory (Tregs) can improve overall disease outcome controlling chronic inflammation but may also suppress beneficial HIV-1 specific immune responses. We aimed to analyze profile Tregs their correlation with status cells activation, expression IL-2 IFNγ antibodies response in Mozambican people living...
Introduction In many African countries, laboratory reference values are not established for the local healthy adult population. Mozambique, known young adults (18-24yo) but yet a wider age range. Our study aimed to establish hematological, biochemical and immunological vaccine trials in Mozambican with high-risk HIV acquisition. Methods A longitudinal cohort site development Mozambique between November 2013 2014 enrolled 505 participants 18 35 years old. Samples from these participants, were...