A5050796481- Antifungal resistance and susceptibility
- Antimicrobial Peptides and Activities
- Probiotics and Fermented Foods
- Fungal Infections and Studies
- Oral microbiology and periodontitis research
- Photodynamic Therapy Research Studies
- Peptidase Inhibition and Analysis
- Head and Neck Cancer Studies
- Invertebrate Immune Response Mechanisms
- Endodontics and Root Canal Treatments
- Nanoplatforms for cancer theranostics
- Genetic factors in colorectal cancer
- Nail Diseases and Treatments
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Essential Oils and Antimicrobial Activity
- Nutrition, Genetics, and Disease
- Herpesvirus Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Aquaculture disease management and microbiota
- Insect Pest Control Strategies
- Oral Health Pathology and Treatment
- Inflammatory mediators and NSAID effects
- Neurobiology and Insect Physiology Research
- Dental Trauma and Treatments
Universidade Federal do Rio Grande do Norte
2021-2024
Universidade Estadual Paulista (Unesp)
2014-2022
Guarulhos University
2021
Brown University
2020
Rhode Island Hospital
2020
Universidade Federal de Minas Gerais
1999-2020
Universidade de São Paulo
2015
This study isolated Lactobacillus strains from caries-free subjects and evaluated the inhibitory effects directly on three of C. albicans, two clinical one reference strain. Thirty were for antimicrobial activity against in vitro albicans biofilms. L. paracasei 28.4, rhamnosus 5.2 fermentum 20.4 isolates exhibited most significant albicans. Co-incubation between these microorganisms resulted deterrence biofilm development retardation hyphal formation. The hindrance was characterized by...
Probiotics have been described as a potential strategy to control opportunistic infections due their ability stimulate the immune system. Using non-vertebrate model host Galleria mellonella, we evaluated whether clinical isolates of Lactobacillus spp. are able provide protection against Candida albicans infection. Among different strains paracasei, rhamnosus and fermentum, verified that L. paracasei 28.4 strain had greatest prolong survival larvae infected with lethal dose C. albicans. We...
In this study, we evaluated the interactions between Candida albicans, krusei and glabrata in mixed infections. Initially, these were studied biofilms formed vitro. CFU/mL values of C. albicans lower when compared to single biofilms, verifying 77% 89% reduction species was associated with krusei, respectively. After that, expanded study for vivo host models experimental candidiasis. G. mellonella larvae inoculated monotypic heterotypic suspensions analysis survival rate quantification fungal...
Candida auris has emerged as a medically important pathogen with considerable resistance to antifungal agents. The ability produce biofilms is an pathogenicity feature of this species that aids escape host immune responses and antimicrobial objective study was verify action using in vitro vivo models the Lactobacillus paracasei 28.4 probiotic cells postbiotic activity crude extract (LPCE) fraction 1 (LPF1), derived from L. supernatant. Both live free supernatant inhibited C. suggesting...
The aim of this study was to evaluate the potential anti-Candida effects Lactobacillus rhamnosus ATCC 9595 on Candida albicans 18804 using in vitro and vivo models.The analysis evaluated L. C. albicans's biofilm formation by CFU count metabolic activity, filamentation capacity, adhesion (ALS3 HWP1) transcriptional regulatory gene (BCR1 CPH1) expression. results showed that both cells supernatant reduced formation, In study, treatment with increased 80% survival Galleria mellonella larvae...
The search for alternative therapies oral candidiasis is a necessity and the use of medicinal plants seems to be one promising solutions. objective this study was evaluate in vitro vivo effects essential oil Melaleuca alternifolia on Candida albicans. minimum inhibitory concentration (MIC) biofilm eradication (MBEC) M. were determined by broth microdilution assay. For study, twelve immunosuppressed mice with buccal received topical applications MBEC. After treatment, yeasts recovered from...
Candida albicans and tropicalis are commensal microorganisms occurring in the oral cavity of approximately 50%-70% healthy individuals. However, these microbes can become pathogenic through changes environment or weakened host immune system. Thus, aim this investigation was to evaluate interaction between species genus biofilm formation, filamentation, gene expression virulence Galleria mellonella. Coincubation C. with cells after 48 h resulted significant reduction formation by decreasing...
Probiotics might provide an alternative approach for the control of oral candidiasis. However, studies on antifungal activity probiotics in cavity are based consumption yogurt or other dietary products, and it is necessary to use appropriate biomaterials specific strains obtain probiotic formulations targeted local administration. In this study, we impregnated gellan gum, a natural biopolymer used as food additive, with investigated its against Candida albicans .
Candida albicans is the main fungal species associated with development of oral candidiasis. Currently, therapeutic options for these infections are limited by adverse effects antifungal drugs and emergence drug resistant strains. Thus, new agents needed prevention treatment infections. Caffeic acid phenethyl ester (CAPE) a natural compound from propolis polyphenolic groups that exhibits many pharmacological properties. In this study, we investigated whether CAPE can have immunomodulatory on...
Aim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans. Methods: The ability of CHT to act in biofilm also interfere with C. albicans adhesion was evaluated, as well the efficiency cryptococcosis candidiasis invertebrate murine models. Results & conclusion: present verified that is found inhibit affecting both inhibited human buccal cells. When evaluated vivo, prolonged survival Galleria mellonella after...
New drugs for the treatment of diabetes, glucagon-like peptide-1 (GLP-1) receptor agonists and inhibitors dipeptidyl peptidase-4 (DPP-4) have shown pleiotropic effects on bone metabolism anti-inflammatory properties. The aim this study is to evaluate exenatide (GLP-1 agonist) sitagliptin (DPP-4 inhibitor) during periodontitis induction by ligature insertion in rats.Forty rats were divided into four groups: 1) animals with induced that received (EG); 2) (SG); 3) without drug (LG); 4)...
Surface pre-reacted glass-ionomer (S-PRG) is a bioactive filler produced by PRG technology, which applied to various dental materials. The inhibitory effects of S-PRG eluate against Candida, the most common fungal oral pathogen, were investigated. Minimum concentrations (MIC) and anti-biofilm activities tested Candida albicans, glabrata, krusei, tropicalis. For in vivo study, Galleria mellonella was used as model evaluate on toxicity, hemocyte counts candidiasis. MIC ranged from 5 40% (v/v)....