A5067687712- Erythrocyte Function and Pathophysiology
- Marine Invertebrate Physiology and Ecology
- Venomous Animal Envenomation and Studies
- Biomedical Research and Pathophysiology
- Ion channel regulation and function
- Blood properties and coagulation
- Neonatal Health and Biochemistry
- Pancreatic function and diabetes
- Biochemical effects in animals
- Advanced Glycation End Products research
- Marine Toxins and Detection Methods
- Medicinal Plants and Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- Heme Oxygenase-1 and Carbon Monoxide
- Marine Sponges and Natural Products
- Carbohydrate Chemistry and Synthesis
- Heavy Metal Exposure and Toxicity
- Galectins and Cancer Biology
- Antioxidants, Aging, Portulaca oleracea
- Ion Transport and Channel Regulation
- Calcium signaling and nucleotide metabolism
- Glycosylation and Glycoproteins Research
- Vitamin C and Antioxidants Research
- Diet, Metabolism, and Disease
- Aldose Reductase and Taurine
University of Messina
2016-2025
Wright State University
2013
Abstract Background Palmitoylethanolamide (PEA) is an endogenous fatty acid amide displaying anti-inflammatory and analgesic actions. Moreover, several data have suggested that PEA reduced inflammation tissue injury associated with spinal cord trauma showed a regulatory role for peroxisome proliferator-activated receptor (PPAR)-α signaling in the neuroprotective effect of PEA. However, other mechanisms could explain anti-hyperalgesic effects PEA, including activation PPAR-δ PPAR-γ. The aim...
Aging is a multi-factorial process developing through complex net of interactions between biological and cellular mechanisms it involves oxidative stress (OS) as well protein glycation. The aim the present work was to verify protective role Quercetin (Q), polyphenolic flavonoid compound, in d-Galactose (d-Gal)-induced model aging human erythrocytes. anion-exchange capability Band 3 (B3p) measured by rate constant SO42− uptake, thiobarbituric acid reactive substances (TBARS) levels—a marker...
During their lifespan, red blood cells (RBCs) are exposed to a large number of stressors and therefore considered as suitable model investigate cell response oxidative stress (OS). This study was conducted evaluate the potential beneficial effects natural antioxidant quercetin (Q) on an OS represented by human RBCs treated with H2O2. Markers OS, including % hemolysis, reactive oxygen species (ROS) production, thiobarbituric acid substances (TBARS) levels, oxidation protein sulfhydryl groups,...
Mercury is a toxic heavy metal widely dispersed in the natural environment. exposure induces an increase oxidative stress red blood cells (RBCs) through production of reactive species and alteration endogenous antioxidant defense system. Recently, among various antioxidants, polyphenols from extra-virgin olive oil (EVOO), important element Mediterranean diet, have generated growing interest. Here, we examined potential protective effects hydroxytyrosol (HT) and/or homovanillyl alcohol (HVA)...
Aging is a process characterised by general decline in physiological functions. The high bioavailability of reactive oxygen species (ROS) plays an important role the aging rate. Due to close relationship between and oxidative stress (OS), functional foods rich flavonoids are excellent candidates counteract age-related changes. This study aimed verify protective Açaì extract d-Galactose (d-Gal)-induced model human erythrocytes. Markers OS, including ROS production, thiobarbituric acid...
Red blood cell (RBC) deformability is the ability of cells to modulate their shape ensure transit through narrow capillaries microcirculation. A loss can occur in several pathological conditions, during natural RBC aging an increase membrane protein phosphorylation, and/or structural rearrangements cytoskeletal proteins due oxidative with a key role played by band 3. Due close relationship between and stress, flavonoid-rich foods are good candidates counteract age-related alterations. This...
Introduction: Aging is a process characterised by decline in physiological functions. Reactive species play crucial role the aging rate. Due to close relationship between and oxidative stress, functional foods rich phytochemicals are excellent candidates neutralise age-related changes. Aim: This investigation aims verify potential protective of bergamot ( Citrus bergamia , Femminello cultivar) peel juice extract model represented human red blood cells (RBCs) exposed D-Galactose (DGal)....
Plastic material versatility has resulted in a substantial increase its use several sectors of our everyday lives. Consequently, concern regarding human exposure to nano-plastics (NPs) and micro-plastics (MPs) recently increased. It been shown that plastic particles entering the bloodstream may adhere erythrocyte surface exert adverse effects following aggregation adhesion blood vessels. Here, we explored polystyrene (PS-NPs) (PS-MPs) on erythrocytes. Cellular morphology,...
Traumatic brain injury (TBI) is a major cause of preventable death and morbidity in young adults. This complex condition characterized by significant blood-brain barrier leakage that stems from cerebral ischemia, inflammation, redox imbalances the traumatic penumbra injured brain. Recovery function after TBI partly through neuronal plasticity. In order to test whether combination therapy with melatonin dexamethasone (DEX) might improve functional recovery, controlled cortical impact (CCI)...
The aim of the present investigation was to verify effect H2O2-induced oxidative stress on SO4= uptake through Band 3 protein, responsible for Cl-/HCO3- as well cell membrane deformability, due its cross link with cytoskeletal proteins. role cytoplasmic proteins binding protein has been also considered by assaying H2O2 effects hemoglobin-free resealed ghosts erythrocytes. Oxidative conditions were induced 30 min exposure human erythrocytes different concentrations (10 300 μM), or without GSH...
Hyperglycemia is considered a threat for cell homeostasis, as it associated to oxidative stress (OS). As erythrocytes are continuously exposed OS, this study was conceived verify the impact of either diabetic conditions attested by glycated hemoglobin (Hb) levels (>6.5% or higher) treatment with high glucose (15-35 mM, 24 h) on erythrocyte homeostasis. To aim, anion exchange capability through Band 3 protein (B3p) monitored rate constant SO42- uptake. Thiobarbituric acid reactive species...
Aging, a time-dependent multifaceted process, affects both cell structure and function involves oxidative stress as well glycation. The present investigation focuses on the role of band 3 protein (B3p), an anion exchanger essential to red cells homeostasis, in d-galactose ( d-Gal)-induced aging model. Anion exchange capability, measured by rate constant SO₄²- uptake through B3p, levels lipid peroxidation, oxidation membrane sulfhydryl groups, B3p expression, methemoglobin, glycated...
exposure to environmental contaminants has been linked an increased risk of neurological diseases and poor outcomes. Chemical name Atrazine (ATR) is 6-chloro-
Abstract The voltage‐gated Kv3.1/KCNC1 channel is abundantly expressed in fast‐spiking principal neurons and GABAergic inhibitory interneurons throughout the ascending auditory pathway various brain regions. Inactivating mutations KCNC1 gene lead to forms of epilepsy a decline expression Kv3.1 involved age‐related hearing loss. As oxidative stress plays fundamental role pathogenesis loss, we hypothesized that an insult might affect function this channel. To verify hypothesis, activity...
Erythrocytes, continuously exposed to oxygen pressure and toxic compounds, are sensitive oxidative stress, namely acting on integral Band 3 protein, with consequences cell membranes deformability anion transport efficiency. The aim of the present investigation, conducted human erythrocytes, is verify whether curcumin (1 or 10µM), a natural compound proved antioxidant properties, may counteract 3-mediated alterations due stress.Oxidative conditions were induced by exposure to, alternatively,...