A5010434230- Pain Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Hormonal and reproductive studies
- Anesthesia and Pain Management
- Menstrual Health and Disorders
- Viral Infections and Immunology Research
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Intensive Care Unit Cognitive Disorders
- Cardiac Fibrosis and Remodeling
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Endometriosis Research and Treatment
- Cardiac Ischemia and Reperfusion
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Nausea and vomiting management
- Spine and Intervertebral Disc Pathology
- Cell Adhesion Molecules Research
Shanghai University of Traditional Chinese Medicine
2023-2025
State Administration of Traditional Chinese Medicine of the People's Republic of China
2023-2025
Women's Hospital, School of Medicine, Zhejiang University
2018-2025
China Medical University
2025
Hunan University of Traditional Chinese Medicine
2025
Zhejiang University
2007-2023
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2023
Yuxian People's Hospital
2023
Wenzhou Medical University
2013-2022
First Affiliated Hospital of Wenzhou Medical University
2013-2022
The transversus abdominis plane (TAP) block has been shown to provide effective postoperative analgesia in lower abdominal surgery. Subcostal TAP also proposed as a new technique for the supraumbilical abdomen. We compared analgesic and opioid-sparing effects of single-injection subcostal with continuous thoracic epidural IV opioid analgesia.Ninety patients undergoing elective radical gastrectomy were randomized receive either combined general-subcostal anesthesia (group TAP),...
Fiberoptic bronchoscopy is a complex procedure with the need for sufficient patient anesthesia/sedation while maintaining safety. This trial aimed to evaluate efficacy, safety, and pharmacokinetics of HSK3486 during fiberoptic bronchoscopy. multicenter, double-blind, randomized, non-inferiority, parallel-group phase 3 was conducted in patients who underwent Patients randomly received 0.4 mg/kg (N = 134) or propofol 2.0 133). The primary efficacy endpoint successful rate bronchoscopy,...
Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with diabetes. The mechanisms mediating DNP are not completely elucidated, effective treatments lacking. A-fiber sensory neurons have been shown to mediate the development of mechanical allodynia pain, yet molecular basis underlying contribution still unclear. Here, we report that orphan G protein-coupled receptor 177 (GPR177) drives via WNT5a-mediated activation transient potential vanilloid receptor-1...
Abstract The ventrolateral periaqueductal gray (vlPAG) collaborates with the dorsal raphe (DR) in pain regulation and emotional response. However, roles of vlPAG DR γ-aminobutyric acid (GABA)-ergic neurons regulating nociception anxiety are contradictory poorly understood. Here, we observed that pharmacogenetic co-activation GABAergic (vlPAG-DR GABA+ ) enhanced sensitivity to mechanical stimulation promoted anxiety-like behavior naïve mice. Simultaneous inhibition vlPAG-DR showed adaptive...
Background: With the development of fiberoptic bronchoscopy in diagnosis and treatment various pulmonary diseases, anesthesia/sedation requirements are becoming more demanding, posing great challenges for patient safety while ensuring a smooth examination/surgery process. Remimazolam, brand-new ultra-short-acting anesthetic, may compensate shortcomings current anesthetic/sedation strategies bronchoscopy. Methods: This study was prospective, multicenter, randomized, double-blind, parallel...
Abstract Estrogen plays substantial roles in pain modulation; however, studies concerning sex hormones and nociception often yield confusing results. The discrepancy could be a result of lack consensus to regard estrogen as variable when working with animal models; thus, the influence hormones’ fluctuations on has continually been neglected. In present study, we designed novel hormone substitution model aid us evaluate effects estrogen’s long-term alterations ovariectomy (OVX)-induced...
Depressive symptoms in adolescents can significantly affect their daily lives and pose risks to future development. These may be linked various factors experienced during both childhood adolescence. Machine learning (ML) has attracted substantial attention the field of adolescent depression; however, studies establishing prediction models have primarily considered or features separately, resulting a lack analyses that incorporate from stages. We collected 39 related Using maximum...
Validated monitoring methods for evaluating the balance of nociception and anti-nociception (BNAN) are needed in general anesthesia. This study assessed six photoplethysmography (PPG) parameters, computed from finger photoplethysmographic waveforms patients undergoing gynecological surgery under A total 20 participants were included, each anesthesia with propofol remifentanil. The same concentration remifentanil was maintained throughout experiment, four different intensities electrical...
Abstract The circadian clock is an important internal time regulatory system for a range of physiological and behavioral rhythms within living organisms. Testosterone, as one the most critical sex hormones, essential development reproductive system, maintenance function, overall health males. secretion testosterone in mammals characterized by distinct closely associated with regulation genes. Here we review central peripheral mechanisms underlying influence genes upon synthesis. We also...
To investigate the relationship between low androgen level and ultrastructure of vascular endothelium.Forty-eight male Sprague-Dawley rats were randomly divided into four groups: group A, normal with sham castration; B, castrated rats; C, given testosterone (T) undecanoate; D, intact treated 5alpha-reductase inhibitor. After 10 weeks treatment or castration, in different groups killed serum T, free T (FT) dihydrotestosterone (DHT) measured. The aortic endothelia scanned under electron...
Background Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II type 1 receptor blockers (ARB) can inhibit tumor growth by inhibition of angiogenesis. This study was designed to the anticancer effects ACEI ARB on lymphangiogenesis in an implanted gastric cancer mouse model. Methods A model established subcutaneously inoculating human cell line SGC-7901 into 60 nude mice. One week later, all mice were randomly divided 5 groups. control group received physiologic saline once...
Endoplasmic reticulum stress-induced neuronal apoptosis contributes to neurotoxicity observed after sevoflurane exposure.However, the molecular mechanism underlying resulting learning and memory impairments remains unknown.Here, we investigated roles of miR-325-3p Nupr1 in sevofluraneinduced neonatal rats HCN-2 human cortical cells.We found that both cells, exposure impairs increases expression Nupr1, endoplasmic stress marker proteins C/EBPβ IGFBP5, apoptosis-related protein markers...
Abstract Menopausal and postmenopausal women, characterized by a significant reduction in ovarian hormones, have high prevalence of chronic pain with great intensity. However, the underlying mechanism hyperalgesia induced hormone withdrawal remains poorly understood. Here, we report that decreases activity excitability GABAergic neurons dorsal raphe nucleus (DRN) are associated ovariectomy mice. Supplementation 17β-estradiol, but not progesterone, is sufficient to increase mechanical...