A5078392945- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- Cancer Immunotherapy and Biomarkers
- X-ray Diffraction in Crystallography
- Renal cell carcinoma treatment
- Immunotherapy and Immune Responses
- Bladder and Urothelial Cancer Treatments
- Renal and Vascular Pathologies
- Immune cells in cancer
- Wastewater Treatment and Nitrogen Removal
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Crystallography and molecular interactions
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Advanced Vision and Imaging
- Advanced Image Processing Techniques
- Advanced Nanomaterials in Catalysis
- Vascular anomalies and interventions
- Topic Modeling
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Research and Treatments
- Curcumin's Biomedical Applications
Shanghai Institute of Materia Medica
2021-2025
Chinese Academy of Sciences
2021-2025
Nanjing University of Finance and Economics
2024-2025
Shenyang University
2018-2025
University of Chinese Academy of Sciences
2021-2024
Tianjin Third Central Hospital
2018-2024
Tianjin Medical University
2018-2024
Nankai University
2021-2024
Zhejiang Cancer Hospital
2024
Anhui University of Technology
2024
Deep learning based approaches has achieved great performance in single image super-resolution (SISR). However, recent advances efficient focus on reducing the number of parameters and FLOPs, they aggregate more powerful features by improving feature utilization through complex layer connection strategies. These structures may not be necessary to achieve higher running speed, which makes them difficult deployed resource-constrained devices. In this work, we propose a novel Residual Local...
The critical challenge for cancer vaccine-induced T-cell immunity is the sustained activation of antigen cross-presentation in antigen-presenting cells (APCs) with innate immune stimulation. In this study, it first discovered that clinically used magnetic contrast agents, iron oxide nanoparticles (IONPs), markedly augment type-I interferon (IFN-I) production profile stimulator genes (STING) agonist MSA-2 and achieve a 16-fold dosage-sparing effect human STING haplotype. Acid-ionizable...
Abstract Cancer immunotherapy has witnessed significant advances in the past decade, however challenges associated with immune‐related adverse effects and immunosuppressive tumor microenvironment, have hindered their clinical application. Stimuli‐activatable nanomedicines hold great potential for improving efficiency of cancer minimizing side via tumor‐specific accumulation, controllable drug release profile, combinational therapy by integrating multiple therapeutic regimens. In this review,...
Cancer immunotherapy is impaired by the intrinsic and adaptive immune resistance. Herein, a bispecific prodrug nanoparticle was engineered for circumventing evasion of tumor cells targeting multiple resistance mechanisms. A disulfide bond-linked NLG919 JQ1 (namely NJ) synthesized self-assembled into nanoparticle, which subsequently coated with photosensitizer-modified acidity-activatable diblock copolymer PHP tumor-specific delivery NJ. Upon accumulation via passive targeting, polymeric...
Ginsenosides, the main active ingredients in Panax ginseng, have been used as an adjuvant to treat diabetes mellitus for many years. Experimental and clinical data emerge support antidiabetic efficacy ginsenosides ascribe their antioxidant, anti-inflammatory, anti-hyperglycemic activities. Existing studies on mechanisms of treatment mostly focused single ginenosides hypoglycemic effect cells animal models. However, a systematical summary how regulate diabetic-related transcriptional factors...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is highly lethal and resistant to conventional therapies, including chemo‐, radio‐, immunotherapy. In this study, it first determined that a combination of dihydroartemisinin (DHA) RSL‐3 (a glutathione peroxidase 4 (GPX4) inhibitor) markedly induced ferroptosis PDAC tumor cells. A mechanistic study revealed DHA can react with iron ions generate carbon radicals deplete intracellular glutathione, thereby cumulatively triggering the lipid...
The investigation on factors that affect the impact of natural organic matter (NOM) colloid transport in complex hydraulic flow systems remains incomplete. Using our previously established approach, interplay rate and particle size NOM effect was quantified, using rates 1 2 mL/min sizes 50 200 nm to represent small nanoparticles (1-100 nm) large non-nano-microspheres (100-1000 low-flow groundwater environment. Latex particles, Suwannee River humic acid (SRHA), iron oxide-coated sand were...
Glioblastoma (GBM) therapy is severely impaired by the blood-brain barrier (BBB) and invasive tumor growth in central nervous system. To improve GBM therapy, we herein presented a dual-targeting nanotheranostic for second near-infrared (NIR-II) fluorescence imaging-guided photo-immunotherapy. Firstly, NIR-Ⅱ fluorophore MRP bearing donor-acceptor-donor (D-A-D) backbone was synthesized. Then, prodrug nanotheranostics were prepared self-assembling with of JQ1 (JPC) T7 ligand-modified...
We characterized bactericidal permeability-increasing proteins (BPIs) of the squid
A growing body of evidence shows that vasculogenic mimicry (VM) is closely related to the invasion and metastasis many tumor cells. Although estrogen receptor (ER) can promote initiation progression renal cell carcinoma (RCC), how downstream biomolecules are involved, detailed mechanisms ER expression elevated in RCC remain be further elucidated. Here, we discovered LncRNA-SERB highly expressed cells patients. We used multiple an vivo mouse model for our study, results indicated could boost...