A5100631654- Anesthesia and Neurotoxicity Research
- Cerebrospinal fluid and hydrocephalus
- Electrospun Nanofibers in Biomedical Applications
- Ultrasound and Cavitation Phenomena
- Advanced Sensor and Energy Harvesting Materials
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Electrohydrodynamics and Fluid Dynamics
University of Maryland, Baltimore
2024
Johns Hopkins University
2023-2024
University of Shanghai for Science and Technology
2013
In this paper we demonstrate for the first time that structural nanocomposites providing dual drug release can be generated using a combination of electrospraying and electrospinning. Ketoprofen (KET) was used as model drug, polyvinylpyrrolidone (PVP) Eudragit® L100-55 (EL100) respectively taken sheath core matrices to prepare nanofibers. Scanning transmission electron microscope observations demonstrated nanofibers had smooth surfaces cross-sections, distinct core–sheath nanostructures....
We introduce a two-pronged strategy comprising focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening and long-circulating biodegradable nanoparticles (NPs) for systemic delivery of nucleic acids to the brain. Biodegradable poly(β-amino ester) polymer-based NPs were engineered stably package various types acid payloads enable prolonged circulation while retaining excellent serum stability. FUS was applied predetermined coordinate within brain transiently open BBB, thereby...
Abstract Drug delivery nanoparticles (NPs) based entirely on materials generally recognized as safe that provide widespread parenchymal distribution following intracranial administration via convection‐enhanced (CED) are introduced. Poly(lactic‐co‐glycolic acid) (PLGA) NPs coated with various poloxamers, including F68, F98, or F127, physical adsorption to render particle surfaces non‐adhesive, thereby resisting interactions brain extracellular matrix. F127‐coated PLGA (F127/PLGA) markedly...