A5045384691- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- RNA Research and Splicing
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- COVID-19 and healthcare impacts
- Lung Cancer Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Radiopharmaceutical Chemistry and Applications
- Alkaloids: synthesis and pharmacology
- Epigenetics and DNA Methylation
- Liver Diseases and Immunity
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Genetic and Kidney Cyst Diseases
- MRI in cancer diagnosis
- Connexins and lens biology
- Protease and Inhibitor Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
Tianjin Medical University
2015-2025
Second Hospital of Tianjin Medical University
2017-2025
Soochow University
2021-2024
Zhongshan People's Hospital
2024
Shanghai Dianji University
2024
Hanzhong People's Hospital
2024
Soochow University
2024
Zhongnan Hospital of Wuhan University
2012-2023
Wuhan University
2012-2023
Southern Medical University
2013-2021
Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in patients with hypertension. Objective: To determine the association between in-hospital use ACEI/ARB all-cause mortality hypertension hospitalized due to COVID-19. Methods Results: This retrospective, multi-center study included 1128 adult diagnosed COVID-19, including 188 taking (ACEI/ARB group;...
The prognostic power of circulating cardiac biomarkers, their utility, and pattern release in coronavirus disease 2019 (COVID-19) patients have not been clearly defined. In this multicentered retrospective study, we enrolled 3219 with diagnosed COVID-19 admitted to 9 hospitals from December 31, March 4, 2020, estimate the associations injury markers poor outcomes COVID-19. mixed-effects Cox model, after adjusting for age, sex, comorbidities, adjusted hazard ratio 28-day mortality hs-cTnI...
Indocyanine green (ICG) fluorescence imaging technology is increasingly widely used in laparoscopic hepatectomy. However, whether it can provide long-term survival benefits to patients with liver malignancies remains unclear. This study investigated the clinical effect of hepatectomy for hepatocellular carcinoma (HCC) using ICG technology. We retrospectively analyzed HCC who underwent at Zhongnan Hospital Wuhan University from January 2016 December 2020. Propensity score matching (PSM) was...
In spite of progress in diagnostics and treatment Hepatocellular Carcinoma (HCC), its prognosis remains poor, improved strategies for HCC require detailed understanding the underlying mechanism. this investigation we studied role Up-frameshift 1 (UPF1) tumorigenesis HCC. We determined expression level UPF1 tissues with quantitative real-time PCR western blotting then clinical significance. Sodium bisulfite sequencing was used to investigate regulation UPF1. explored biological significance...
Infection with the hepatitis B virus (HBV) is closely associated development of hepatocellular carcinoma (HCC). The osmoregulatory transcription factor nuclear activated T-cells 5 (NFAT5) has been shown to play an important role in many types human cancers. NFAT5 HBV-associated HCC never previously investigated. We compared expression profiles NFAT5, DARS2 and miR-30e-5p samples, adjacent nontumor tissues different hepatoma cell lines by quantitative real-time polymerase chain reaction /or...
Phosphodiesterase-4 (PDE4) inhibitors enhance memory, increase hippocampal neurogenesis, and reverse amyloid-β (Aβ)-induced memory deficits. Here, we examined whether long-form PDE4D knockdown by lentiviral RNA construct containing a specific microRNA/miRNA-mir hairpin structure (4DmiRNA) reversed impairment caused amyloid-β1-42 (Aβ42) in mice using the Morris water maze (MWM) novelty object recognition tests. Western blotting analysis was used to assess protein levels of cAMP response...
Long intergenic non-coding RNA 00152 (LINC00152) is aberrantly expressed in various human malignancies and plays an important role the pathogenesis. Here, we found that LINC00152 upregulated hepatocellular carcinoma (HCC) tissues as compared to adjacent non-neoplastic tissues; gain-and-loss-of-function analyses vitro showed facilitates HCC cell cycle progression through regulating expression of CCND1. knockdown inhibits tumorigenesis vivo. MS2-RIP analysis indicated binds directly...
Abstract Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently discovered autoimmune syndrome associated with psychosis, dyskinesia, and seizures. However, the underlying mechanisms of this disease remain unclear, in part because lack suitable animal models. Methods This study describes novel female C57BL/6 mouse model anti-NMDAR that was induced by active immunization against NMDARs using an amino terminal domain (ATD) peptide from GluN1 subunit (GluN1 356–385 )....
Abstract Our previous studies have indicated that long noncoding RNA (lncRNA) SPRY4 intronic transcript 1 (SPRY4‐IT1) was highly expressed in hepatocellular carcinoma (HCC). However, it still remained unclear how SPRY4‐IT1 worked tumorgenesis HCC. In this study, we tested the overexpression of HCC tissues and cells through a quantitative real‐time polymerase chain reaction. Statistical analyses showed upregulation had an association with tumor node metastasis stage, thrombin time, alkaline...
BACKGROUND We investigated the utility of gamma-glutamyl transferase-to-lymphocyte ratio (GLR) as a predictive indicator for postoperative survival in patients with hepatocellular carcinoma (HCC) across different time periods and developed model based on this. AIM To evaluate prognostic accuracy GLR overall (OS) HCC its impact over time. METHODS This study enrolled 301 treated curative hepatectomy. Exclusion criteria included non-HCC hepatic malignancies, inadequate records, prior cancer...
e17048 Background: Prostate cancer (PC) often develops resistance to androgen deprivation therapy (ADT) due various secondary molecular mechanisms like AR amplification, mutation, and aberrations in the PI3K or NF-κB pathways, leading progression metastatic castration-resistant prostate (mCRPC). CDK12 -mutated PC is highly aggressive resistant ADT, PARP inhibitors, immunotherapy, although some patients benefit from ADT. This study aims analyze underlying sensitivity of endocrine using...
The pathophysiological mechanisms underlying diverticular disease (DD) remain incompletely understood, and there is considerable debate regarding the roles of gut microbiome features inflammation-related proteins in development disease. In this study, we employed mediation Mendelian randomization (MR) analysis to investigate causal relationships among these 3 factors. conducted a MR on genome-wide association studies data 412 (207 microbial taxa 205 pathways), 91 proteins, DD. We...
Many insect-transmissible pathogens are transmitted by specific insect species and not others, even if the closely related. The molecular mechanisms underlying such strict pathogen-insect specificity poorly understood. Rice dwarf virus (RDV), a plant reovirus, is mainly leafhopper Nephotettix cincticeps but ineffectively Recilia dorsalis. Here, we demonstrated that virus-containing tubules composed of viral non-structural protein Pns10 RDV associated with intestinal microvilli N. those R....