A5040823774- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Cell death mechanisms and regulation
- Advanced Drug Delivery Systems
- Organ Transplantation Techniques and Outcomes
- Gastric Cancer Management and Outcomes
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Cholinesterase and Neurodegenerative Diseases
- Liver Disease and Transplantation
- Esophageal and GI Pathology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Corneal Surgery and Treatments
- Cytomegalovirus and herpesvirus research
- Cancer therapeutics and mechanisms
- Microbial Metabolism and Applications
- Autophagy in Disease and Therapy
- Ginger and Zingiberaceae research
- DNA and Nucleic Acid Chemistry
- Drug Solubulity and Delivery Systems
- Esophageal Cancer Research and Treatment
Chengdu University of Traditional Chinese Medicine
2023-2025
Suizhou Central Hospital
2023-2024
Xuzhou Medical College
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2019
Stony Brook University
2017-2018
Stony Brook Medicine
2017
China Academy of Chinese Medical Sciences
2017
Peking Union Medical College Hospital
2017
Fudan University
2011-2013
American Pharmacists Association
2012
A brain drug delivery system for glioma chemotherapy based on transferrin-conjugated biodegradable polymersomes, Tf-PO−DOX, was made and evaluated with doxorubicin (DOX) as a model drug. Biodegradable polymersomes (PO) loaded were prepared by the nanoprecipitation method (PO−DOX) then conjugated transferrin (Tf) to yield Tf-PO−DOX an average diameter of 107 nm surface Tf molecule number per polymersome approximately 35. Compared PO−DOX free DOX, demonstrated strongest cytotoxicity against C6...
Superparamagnetic Fe3O4 nanoparticles with positive surface ξ-potential were synthesized via a solvothermal route. After was mixed HAuCl4 and NaBH4, the reduced Au could be directly adsorbed onto of nanoparticles. The as-synthesized nanocomposites successfully applied to photothermal destruction cancer cells.
Abstract Background: Transjugular intrahepatic portosystemic shunt (TIPS) is the main method to prevent rebleeding of esophagogastric varices. Many studies have demonstrated that pre-emptive TIPS (p-TIPS) superior medicine combined with endoscopic standard therapy in efficacy high-risk patients, but very few relevant reported whether p-TIPS more effective than elective TIPS. This study aims compare and prognosis for treatment variceal bleeding (EGVB) patients cirrhosis. Methods: In this...
Background: A novel brain drug delivery system using cationic bovine serum albumin (CBSA)-conjugated biodegradable polymersomes (CBSA-PO) was prepared, and its intracellular mechanism kinetics were evaluated. Methods results: Biodegradable poly(ethylene glycol)-poly(ε -caprolactone) (PEG-PCL) used to prepare the polymersomes, thiolated CBSA conjugated with surface of polymersome. Transmission electron microscopy dynamic light scattering showed that CBSA-PO had a round vesicle-like shape,...
In this paper, a facile solvothermal synthesis method was developed to prepare monodisperse magnetites anchored onto multi-walled carbon nanotubes (MWNTs). The pristine MWNTs were treated with mixture of concentrated sulfuric and nitric acids. oxidized (o-MWNTs) had abundant carboxylic groups on the surface, which have strong ability chelate metal ions like Fe3+. obtained MWNTs–Fe3O4 nanomaterials allowed π–π stacking fluorescein isothiocyanate (FITC) monitor inside living cancer cells by...
Various factors controlling the accumulation of natural gas hydrates (NGHs) form various enrichment and modes through organic combination. This study mainly analyzes geological geophysical characteristics NGHs occurrence in uplifts their slope zones within deep-water area Qiongdongnan (QDN) Basin (also referred to as area). Furthermore, it investigates dominant governing models migration area. The results are follows. (1) lie pressure-relief direction fluids central hydrocarbon-rich sags...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a novel anticancer agent for non-small cell lung cancer (NSCLC). However, approximately half of NSCLC lines are highly resistant to TRAIL. Doxorubicin (DOX) can sensitize cells TRAIL-induced apoptosis, indicating the possibility combination therapy. Unfortunately, therapeutic effect DOX and TRAIL limited by multiple factors including short serum half-life TRAIL, poor compliance application difficulty in clinic, chronic...
We studied the pharmacokinetics, biodistribution and metabolism of phospho-sulindac (PS), a novel agent efficacious in treatment dry eye, formulated nanoparticles (PS-NPs) following its topical administration to eye New Zealand White rabbits. The were spherical with effective diameter = 108.9 ± 41.7 nm, zeta potential −21.70 3.78 mV, drug loading 7%, entrapment efficiency 46.4%. Of total PS delivered topically >95% was retained anterior segment, predominantly cornea (Cmax 101.3 μM; Tmax 1 h;...
Structure–activity relationship (SAR) study of a series unsaturated crotonic acid derivatives as potential PknB inhibitors.
The apical sodium--dependent bile acid transporter (ASBT) is the main to promote re-absorption of acids from intestinal tract into enterohepatic circulation. Inhibition ASBT could increase excretion acids, thus increasing synthesis and consequently cholesterol consumption. Therefore, an attractive target for developing new cholesterol-lowering drugs. In this report, a series 1-(2,4-bifluorophenyl)-7-dialkylamino-1,8-naphthyridine-3-carboxamides were designed as inhibitors ASBT. Most them...
The inhibitors of the REV7/REV3L protein interaction bind to two pockets REV7 divided by ‘safety-belt’ structure, as revealed computational modeling.
An anastomotic fistula is a severe complication of post-gastrectomy. In the past, re-surgery has been most common method to address this [1]. However, it may bring many subsequent complications [2]. With development endoscopic techniques and related accessories, endoscopy gradually able more post-surgical complications. Here, we report case dual-endoscopy detection suture an esophageal-jejunal anastomosis fistula.
A 36-year-old woman presented with recurrent lower abdominal pain for 6 months. Abdominal contrast-enhanced computed tomography (CT) showed a 1.2-mm enhancing lesion in the upper rectum ([Fig. 1]). Intestinal endoscopy revealed 1.5 × 1.2-cm rectal mass located 15 cm from anal dentate line 2]). Mucosal biopsy indicated mild chronic inflammation. Endoscopic ultrasonography 2.2-cm submucosal an intact mucosal layer 3]). After obtaining consent patient, tumor endoscopic resection was planned,...