Human-Precision Medicine Interaction: Public Perceptions of Polygenic Risk Score for Genetic Health Prediction

• DOI: 10.1145/3706598.3713567
• Publication Date: 2025-01-31
• Authors: Yuhao Sun; Albert Tenesa; John Vines
• Keywords: Polygenic risk score

Precision Medicine (PM) transforms the traditional "one-drug-fits-all" paradigm by customising treatments based on individual characteristics, and is an emerging topic for HCI research digital health. A key element of PM, Polygenic Risk Score (PRS), uses genetic data to predict individual's disease risk. Despite its potential, PRS faces barriers adoption, such as inclusivity, psychological impact, public trust. We conducted a mixed-methods study explore how people perceive PRS, formed surveys (n=254) interviews (n=11) with UK-based participants. The were supplemented interactive storyboards ContraVision technique provoke deeper reflection discussion. identified ten five themes adoption proposed design implications responsible framework. To address complexities enhance broader PM practices, we introduce term Human-Precision Interaction (HPMI), which integrates, adapts, extends approaches better meet these challenges.