Understanding the role of serological and clinical data on assessing the dynamic of malaria transmission: a case study of Bagamoyo district, Tanzania.

• DOI: 10.11604/pamj.2022.43.60.35779
• Publication Date: 2022-01-01
• Authors: Tunu G. Mwamlima; Solomon Mwakasungula; Catherine Mkindi; Mgeni M. Tambwe; Sarah Mswata; Stephen G. Mbwambo; Michael Fred Mboya; Simon J. Draper; Sarah E. Silk; Maxmillian Mpina; John‐Mary Vianney; Ally Olotu
• Keywords: Rapid diagnostic test; Tropical Medicine

naturally acquired blood-stage malaria antibodies and clinical data have been reported to be useful in monitoring change over time as a marker of exposure. This study assessed the total immunoglobulin G (IgG) levels Plasmodium falciparum schizont among infants (5-17 months), estimated incidence using routine health facility-based surveillance predicted trend relation between anti-schizont Bagamoyo.252 serum samples were used for assessment IgG by enzyme-linked immunosorbent assay results expressed arbitrary units (AU). 147/252 collected 2021 during vaccine trial [ClinicalTrials.gov NCT04318002], 105/252 archived conducted 2012 NCT00866619]. Malaria was calculated from outpatient clinic rapid test or blood smear positive retrieved District-Health-Information-Software-2 (DHIS2) 2013 2020. Cross-sectional both studies analysed STATA version 14.this demonstrated decline 490.21AU 97.07AU which related fall 58.25 cases/1000 person-year 14.28 We also observed significant difference when comparing high low transmission areas gender. However, we did not observe differences gender year.total antibody appear an important serological exposure assessing dynamic living malaria-endemic regions.