A5047658610- Mosquito-borne diseases and control
- COVID-19 Digital Contact Tracing
- Viral Infections and Outbreaks Research
- Malaria Research and Control
- Parasites and Host Interactions
- Data-Driven Disease Surveillance
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- ICT in Developing Communities
- Viral Infections and Vectors
- Dengue and Mosquito Control Research
- Iron Metabolism and Disorders
- Vector-Borne Animal Diseases
- Hemoglobinopathies and Related Disorders
- Computational Drug Discovery Methods
- Insect symbiosis and bacterial influences
- Vaccine Coverage and Hesitancy
- Zoonotic diseases and public health
- Neonatal Health and Biochemistry
Ifakara Health Institute
2014-2024
University of Basel
2014
Swiss Tropical and Public Health Institute
2014
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI) of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ) (PfSPZ Challenge) to try reduce time and costs developing PfSPZ Vaccine prevent in Africa. Immunization with five doses at 0, 4, 8, 12, 20 weeks 2.7 × 105 gave 65% vaccine efficacy (VE) 24 against mosquito bite CHMI U.S. adults 52% (time event) or 29% (proportional) VE over naturally transmitted Pf Malian adults. assessed the...
Abstract The rapid and accurate diagnosis of Plasmodium falciparum malaria infection is an essential factor in control. Currently, the field depends heavily on using diagnostic tests (RDTs) many which detect circulating parasite-derived histidine-rich protein 2 antigen (PfHRP2) capillary blood. P . strains lacking PfHRP2, due to pfhrp2 gene deletions, are emerging threat control programs. novel assay described here, named qHRP2/3-del, well suited for high-throughput screening isolates...
Many emerging infectious diseases originate from wild animals, so there is a profound need for surveillance and monitoring of their pathogens. However, the practical difficulty sample acquisition animals tends to limit feasibility effectiveness such surveys. Xenosurveillance, using blood-feeding invertebrates obtain tissue samples then detect pathogens, promising method do so. Here, we describe use tsetse fly blood meals determine (directly through molecular diagnostic indirectly serology),...
In Zanzibar, from the start of pandemic in March 2020 to time sampling December 2020, SARS-CoV-2 seroprevalence data was limited. We conducted a study evaluate magnitude exposure among healthcare workers, school children, and people who attended general markets Zanzibar. The objectives were analyse total antibodies selected higher-risk population groups order determine SARS CoV-2 exposure. Blood samples collected eligible consented participants (adults children), their serum analyzed for...
naturally acquired blood-stage malaria antibodies and clinical data have been reported to be useful in monitoring change over time as a marker of exposure. This study assessed the total immunoglobulin G (IgG) levels Plasmodium falciparum schizont among infants (5-17 months), estimated incidence using routine health facility-based surveillance predicted trend relation between anti-schizont Bagamoyo.252 serum samples were used for assessment IgG by enzyme-linked immunosorbent assay results...
Abstract Introduction The PANDORA-ID-NET consortium aims to build capacity for effective outbreak response in sub-Saharan Africa. Part of this mission is develop a real-time data sharing platform disease outbreaks that leverages centralised management and uses mobile technologies gathering feedback. We have committed using open-source technologies, so the can be deployed on regional IT infrastructure further developed by local staff, collected stored processed region origin. This abstract...