A5001004624- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer therapeutics and mechanisms
- Antibiotic Use and Resistance
- Pediatric health and respiratory diseases
- Bacterial Identification and Susceptibility Testing
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- Evolution and Genetic Dynamics
- Bacterial biofilms and quorum sensing
- Microbial infections and disease research
- Zoonotic diseases and public health
- Bacteriophages and microbial interactions
- Respiratory and Cough-Related Research
- Enterobacteriaceae and Cronobacter Research
University College London
2016-2025
University Medical Center
2025
Institute of Medical Microbiology and Hygiene
2025
Helmholtz Zentrum München
2025
Uppsala University
2025
University of California, San Francisco
2025
Radboud University Nijmegen
2025
Radboud University Medical Center
2025
Ludwig-Maximilians-Universität München
2025
Roland Hill (United Kingdom)
2014-2024
The October 2020 Global TB report reviews control strategies and United Nations (UN) targets set in the political declaration at September 2018 UN General Assembly high-level meeting on held New York. Progress care prevention has been very slow. In 2019, remained most common cause of death from a single infectious pathogen. Globally, an estimated 10.0 million people developed disease there were 1.2 deaths among HIV-negative additional 208, 000 living with HIV. Adults accounted for 88%...
Patients with highly drug-resistant forms of tuberculosis have limited treatment options and historically had poor outcomes.
Early-phase and preclinical studies suggest that moxifloxacin-containing regimens could allow for effective 4-month treatment of uncomplicated, smear-positive pulmonary tuberculosis.
Tuberculosis regimens that are shorter and simpler than the current 6-month daily regimen needed.
The bedaquiline-pretomanid-linezolid regimen has been reported to have 90% efficacy against highly drug-resistant tuberculosis, but the incidence of adverse events with 1200 mg linezolid daily high. appropriate dose and duration treatment this agent minimize toxic effects while maintaining tuberculosis are unclear.We enrolled participants extensively (XDR) (i.e., resistant rifampin, a fluoroquinolone, an aminoglycoside), pre-XDR rifampin either fluoroquinolone or rifampin-resistant that was...
Rifampin at a dose of 10 mg/kg was introduced in 1971 based on pharmacokinetic, toxicity, and cost considerations. Available data mice humans showed that an increase may shorten the duration tuberculosis treatment.To evaluate safety tolerability, pharmacokinetics, extended early bactericidal activity increasing doses rifampin.Patients with drug-susceptible were enrolled into control group eight patients receiving standard rifampin, followed by consecutive experimental groups 15 each rifampin...
ABSTRACT The rapid identification of antimicrobial resistance is essential for effective treatment highly resistant Mycobacterium tuberculosis . Whole-genome sequencing provides comprehensive data on mutations and strain typing monitoring transmission, but unlike conventional molecular tests, this has previously been achievable only from cultures M. Here we describe a method utilizing biotinylated RNA baits designed specifically DNA to capture full genomes directly infected sputum samples,...
Prevalence and load of airway bacteria in stable exacerbated chronic obstructive pulmonary disease (COPD) has been previously studied using microbiological culture. Molecular techniques, such as quantitative PCR (qPCR), may be more informative.In this study, 373 sputum samples from 134 COPD outpatients were assessed for prevalence typical (Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis) by multiplex qPCR, with 176 analysed atypical bacteria. Paired exacerbation data...
Recurrence of tuberculosis after treatment makes management difficult and is a key factor for determining efficacy. Two processes can cause recurrence: relapse the primary infection or re-infection with an exogenous strain. Although does occur, its importance to epidemiology biological basis still debated. We used whole-genome sequencing-which more accurate than conventional typing date-to assess frequency recurrence gain insight into re-infection.We assessed patients from REMoxTB trial-a...
In patients with rifampin-resistant tuberculosis, all-oral treatment regimens that are more effective, shorter, and have a acceptable side-effect profile than current needed.We conducted an open-label, phase 2-3, multicenter, randomized, controlled, noninferiority trial to evaluate the efficacy safety of three 24-week, for tuberculosis. Patients in Belarus, South Africa, Uzbekistan who were 15 years age or older had pulmonary tuberculosis enrolled. stage 2 trial, 24-week regimen bedaquiline,...
<h2>Summary</h2><h3>Background</h3> Directly observed treatment (DOT) has been the standard of care for tuberculosis since early 1990s, but it is inconvenient patients and service providers. Video-observed therapy (VOT) conditionally recommended by WHO as an alternative to DOT. We tested whether levels observation were improved with VOT. <h3>Methods</h3> did a multicentre, analyst-blinded, randomised controlled superiority trial in 22 clinics England (UK). Eligible participants aged at least...
The current methods available to diagnose antimicrobial-resistant Mycobacterium tuberculosis infections require a positive culture or only test limited number of resistance-associated mutations. A rapid accurate identification antimicrobial resistance enables the prompt initiation effective treatment.
The World Health Organization defines a zoonosis as any infection naturally transmissible from vertebrate animals to humans. pandemic of Coronavirus disease (COVID-19) caused by SARS-CoV-2 has been classified zoonotic disease, however, no animal reservoir yet found, so this classification is premature. We propose that COVID-19 should instead be an “ emerging infectious (EID) probable origin .” To explore if fits our proposed re-categorization vs. the contemporary definitions zoonoses, we...