A5070647783- Herpesvirus Infections and Treatments
- Congenital Heart Disease Studies
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Poxvirus research and outbreaks
- Virus-based gene therapy research
- Cardiovascular Function and Risk Factors
- Respiratory viral infections research
- Parvovirus B19 Infection Studies
- Viral-associated cancers and disorders
- Congenital Diaphragmatic Hernia Studies
- Bartonella species infections research
- SARS-CoV-2 detection and testing
- Vector-borne infectious diseases
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Acne and Rosacea Treatments and Effects
- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
- Cervical Cancer and HPV Research
- Advanced MRI Techniques and Applications
- Tuberculosis Research and Epidemiology
University College London
2016-2025
University Hospital Bonn
2016-2025
Great Ormond Street Hospital
2016-2025
Fraunhofer Institute for Integrated Systems and Device Technology
2024
Great Ormond Street Hospital for Children NHS Foundation Trust
2015-2024
Fraunhofer Institute for Industrial Engineering
2024
Institute of Infection and Immunity
2015-2024
Siemens Healthcare (Germany)
2014-2024
National Health Service
2007-2024
Institute of Child Health
2022-2023
The role of human papillomavirus (HPV) in anogenital carcinogenesis is established firmly, but a similar non-melanoma skin cancer remains speculative. Certain immunosuppressed individuals have an increased incidence both viral warts and cancer, that has prompted the suggestion HPV may play pathogenic role. Differences techniques used to detect DNA skin, however, led discrepancies prevalence spectrum types reported these malignancies. This study describes use comprehensive degenerate PCR...
ABSTRACT The rapid identification of antimicrobial resistance is essential for effective treatment highly resistant Mycobacterium tuberculosis . Whole-genome sequencing provides comprehensive data on mutations and strain typing monitoring transmission, but unlike conventional molecular tests, this has previously been achievable only from cultures M. Here we describe a method utilizing biotinylated RNA baits designed specifically DNA to capture full genomes directly infected sputum samples,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the globe after its emergence in Wuhan December 2019. With no specific therapeutic and prophylactic options available, virus has infected millions of people which more than half a million succumbed to viral disease, COVID-19. The urgent need for an effective treatment together with lack small animal infection models led clinical trials using repurposed drugs without preclinical evidence their vivo efficacy. We...
Human IFNAR2 deficiency causes fatal susceptibility to live viral vaccines.
Herpes zoster (HZ, shingles) is a frequent medical condition which may severely impact the quality of life affected patients. Different therapeutic approaches to treat acute HZ are available. The aim this European project was elaboration consensus-based guideline on management patients who present with HZ, considering different patient populations and localizations. This interdisciplinary aims at an improvement outcomes concerning disease duration, pain reduction in incidence postherpetic...
Background. An 18-month-old boy developed encephalopathy, for which extensive investigation failed to identify an etiology, 6 weeks after stem cell transplant. To exclude a potential infectious cause, we performed high-throughput RNA sequencing on brain biopsy.
The current methods available to diagnose antimicrobial-resistant Mycobacterium tuberculosis infections require a positive culture or only test limited number of resistance-associated mutations. A rapid accurate identification antimicrobial resistance enables the prompt initiation effective treatment.
Favipiravir and Molnupiravir, orally available antivirals, have been reported to exert antiviral activity against SARS-CoV-2. First efficacy data recently in COVID-19 patients.We here report on the combined effect of both drugs a SARS-CoV-2 Syrian hamster infection model. The infected hamsters were treated twice daily with vehicle (the control group) or suboptimal dose each compound combination compounds.When animals doses Molnupiravir at time infection, marked potency endpoint is observed....
Certain infectious agents are recognised causes of cancer and other chronic diseases. To understand the pathological mechanisms underlying such relationships, here we design a Multiplex Serology platform to measure quantitative antibody responses against 45 antigens from 20 including human herpes, hepatitis, polyoma, papilloma, retroviruses, as well Chlamydia trachomatis, Helicobacter pylori Toxoplasma gondii, then assayed random subset 9695 UK Biobank participants. We find seroprevalence...
Abstract Children infected with SARS-CoV-2 rarely progress to respiratory failure. However, the risk of mortality in people over 85 years age remains high. Here we investigate differences cellular landscape and function paediatric (<12 years), adult (30–50 years) older (>70 ex vivo cultured nasal epithelial cells response infection SARS-CoV-2. We show that cell tropism SARS-CoV-2, expression ACE2 TMPRSS2 subtypes, differ between groups. While ciliated are viral replication centres...
Abstract Viral clearance, antibody response and the mutagenic effect of molnupiravir has not been elucidated in at-risk populations. Non-hospitalised participants within 5 days SARS-CoV-2 symptoms randomised to receive (n = 253) or Usual Care 324) were recruited study viral dynamics on whole genome sequence from 1437 genomes. Molnupiravir accelerates load decline, but virus is detectable by Day most cases. At 14 (9 post-treatment), associated with significantly higher persistence lower...
Abstract Aims/hypothesis The nPOD-Virus group collaboratively applied innovative technologies to detect and sequence viral RNA in pancreas other tissues from organ donors with type 1 diabetes. These analyses involved the largest number of samples collected date. aim current work was examine presence enterovirus lymphoid without Methods We analysed pancreas, spleen, pancreatic lymph nodes duodenum following groups: (1) diabetes ( n =71) =35) or =36) insulin-containing islets; (2) single...
SUMMARY Recent information on epidemiology and management of herpes zoster (HZ) post-herpetic neuralgia (PHN), a painful complication HZ, is scarce. The objective this study was to document the burden HZ PHN in United Kingdom. This retrospective analysis UK General Practice Research Database aimed estimate incidence proportion patients developing assess costs immunocompetent individuals aged ⩾50 years. A cohort 27 225 selected, corresponding an 5·23/1000 person-years. Respectively 19·5%...
Whole genome sequencing of viruses directly from clinical samples is integral for understanding the genetics host-virus interactions. Here, we report use sample sparing target enrichment (by hybridisation) viral nucleic acid separation and deep-sequencing herpesvirus genomes a range including saliva, blood, virus vesicles, cerebrospinal fluid, tumour cell lines. We demonstrate effectiveness method by 13 highly cell-associated human generating full length alignments at high read depth....
Background —Hypertrophic cardiomyopathy (HCM) often causes sudden, unexpected death in adolescents and young adults. Alterations myocardial metabolism are considered to be for contractile dysfunction. We examined the question of whether metabolic abnormalities antedate manifestation symptoms patients with HCM. Methods Results —Proton-decoupled 31 P NMR spectroscopy anterior left ventricular wall heart 14 young, asymptomatic HCM was performed a 1.5-T whole-body imager. Spectra phosphate...