Nicholas Thomas
A5079121335- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Long-Term Effects of COVID-19
- Diabetes Management and Research
- Data-Driven Disease Surveillance
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Respiratory viral infections research
- Electronic Health Records Systems
- SARS-CoV-2 detection and testing
- Health Systems, Economic Evaluations, Quality of Life
- Intensive Care Unit Cognitive Disorders
- Physical Activity and Health
- Vaccine Coverage and Hesitancy
- Healthcare Quality and Management
- Clinical practice guidelines implementation
- Medical Malpractice and Liability Issues
- Pressure Ulcer Prevention and Management
- Health Policy Implementation Science
- Advanced Causal Inference Techniques
- Economic and Financial Impacts of Cancer
Royal College of General Practitioners
2020-2024
National Institute for Health Research
2021-2024
NIHR Clinical Research Network
2021-2024
Clinical Research Network Thames Valley and South Midlands
2022-2024
Leicester General Hospital
2023
University of Leicester
2023
UK Research and Innovation
2021
Imperial College London
2021
The University of Queensland
2021
University of Oxford
2020-2021
<h2>Summary</h2><h3>Background</h3> Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has been used to treat COVID-19, but evidence from community randomised trials is lacking. We aimed assess the effectiveness of azithromycin suspected COVID-19 among people in who had increased risk complications. <h3>Methods</h3> In this UK-based, primary care, open-label, multi-arm, adaptive platform trial interventions against at adverse clinical course (PRINCIPLE),...
Abstract Viral clearance, antibody response and the mutagenic effect of molnupiravir has not been elucidated in at-risk populations. Non-hospitalised participants within 5 days SARS-CoV-2 symptoms randomised to receive (n = 253) or Usual Care 324) were recruited study viral dynamics on whole genome sequence from 1437 genomes. Molnupiravir accelerates load decline, but virus is detectable by Day most cases. At 14 (9 post-treatment), associated with significantly higher persistence lower...
Background The Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) Public Health England (PHE) have successfully worked together on the surveillance influenza other infectious diseases for over 50 years, including three previous pandemics. With emergence international outbreak coronavirus infection (COVID-19), a UK national approach to containment has been established test people suspected exposure COVID-19. At same time separately, RCGP RSC’s extended...
Background: The safety, effectiveness and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, in patients the community who are multiply-vaccinated at increased risk morbidity mortality from COVID-19, has not been established. We aimed to determine whether molnupiravir added usual care reduced hospital admissions/deaths among people higher here report our preliminary analyses.Methods: Participants this UK multicentre, open-label, adaptive, multi-arm, platform,...
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at time stage 3 type 1 diabetes diagnosis, and emerging availability therapy delay disease progression, programmes are being increasingly emphasised. Once broadly implemented, initiatives will identify significant numbers islet autoantibody-positive (IAb
Routinely recorded primary care data have been used for many years by sentinel networks surveillance. More recently, real world a wider range of research projects to support rapid, inexpensive clinical trials. Because the partial national lockdown in United Kingdom due coronavirus disease (COVID-19) pandemic has resulted decreasing community incidence, much larger numbers general practices are needed deliver effective COVID-19 surveillance and contribute in-pandemic
Background Colchicine has been proposed as a COVID-19 treatment. Aim To determine whether colchicine reduces time to recovery and COVID-19-related admissions hospital and/or deaths among people in the community. Design setting Prospective, multicentre, open-label, multi-arm, randomised, controlled, adaptive platform trial (PRINCIPLE). Method Adults aged ≥65 years or ≥18 with comorbidities shortness of breath, unwell for ≤14 days suspected community, were randomised usual care, care plus (500...
Introduction There is an urgent need to determine the safety, effectiveness and cost-effectiveness of novel antiviral treatments for COVID-19 in vaccinated patients community at increased risk morbidity mortality from COVID-19. Methods analysis PANORAMIC a UK-wide, open-label, prospective, adaptive, multiarm platform, randomised clinical trial that evaluates community. A master protocol governs addition new as they become available, introduction cessation existing interventions via interim...
The cost-effectiveness of molnupiravir, an oral antiviral for early treatment SARS-CoV-2, has not been established in vaccinated populations.
Background Prepandemic sentinel surveillance focused on improved management of winter pressures, with influenza-like illness (ILI) being the key clinical indicator. The World Health Organization (WHO) global standards for influenza include monitoring acute respiratory infection (ARI) and ILI. WHO’s mosaic framework recommends that strategies countries virological viruses pandemic potential such as influenza. Oxford-Royal College General Practitioner Research Surveillance Centre (RSC) in...
Abstract Background It remains unclear to what extent reductions in urgent referrals for suspected cancer during the COVID-19 pandemic were result of fewer patients attending primary care compared GPs referring patients. Methods Cohort study including electronic health records data from 8,192,069 663 English practices. Weekly consultation rates, cumulative consultations and calculated 28 clinical features NICE guidelines. Clinical feature rate ratios (CRR) referral (RRR) time periods 2020...
Severe acute respiratory syndrome (SARS) is now a global public health threat with many medical, ethical, social, economic, political, and legal implications. (Abdullah et al. 2003 Abdullah ASM ‘Lessons from the severe outbreak in Hong Kong’ Emerging Infectious Diseases Journal [online] September. Available from: URL: http://www.cdc.gov/ncidod/EID/vol9no9/03–0366.htm [Crossref] , [Google Scholar]) No man an island. (John Donne) The security of state dependent on its individual citizens. If...
Abstract BACKGROUND Inhaled budesonide has shown efficacy for treating COVID-19 in the community but not yet been tested effectiveness trials. METHODS We performed a multicenter, open-label, multi-arm, adaptive platform randomized controlled trial involving people aged ≥65 years, or ≥50 years with comorbidities, and unwell ≤14 days suspected (PRINCIPLE). Participants were to usual care, care plus inhaled (800µg twice daily 14 days), other interventions. The co-primary endpoints are time...
There is an urgent need to idenfy treatments for COVID-19 that reduce illness duration and hospital admission in those at higher risk of a longer course complications.The Platform Randomised trial INterventions against In older peoPLE open-label, multiarm, prospective, adaptive platform, randomised clinical evaluate potential the community. A master protocol governs addition new interventions as they become available, well inclusion cessation existing intervention arms via frequent interim...
Background Healthcare systems are under unprecedented pressure. GPs crucial to the health of population, yet their own and wellbeing is often overlooked. Aim To investigate feelings burnout, psychological wellbeing, musculoskeletal complaints in across UK examine whether these outcomes vary according time spent sitting, participation physical activity each day, working per day or week. Design & setting Observational study involving located UK. Method An online survey was emailed members...
Introduction This analysis explores the association between elements of surgical efficiency in voluntary medical male circumcision (VMMC), quality technique, and amount time required to conduct VMMC procedures actual field settings. Efficiency outcomes are defined terms primary provider’s with client (PPTC) total elapsed operating (TEOT). Methods Two serial cross-sectional surveys sites were conducted Kenya, Republic South Africa, Tanzania Zimbabwe 2011 2012. Trained clinicians observed...
Type 1 diabetes (T1D) screening programmes testing islet autoantibodies (IAbs) in childhood can reduce life-threatening diabetic ketoacidosis. General population is required to detect the majority of children with T1D, since >85% there no family history. Age 3-5 years has been proposed as an optimal age for a single screen approach.