Anette‐Gabriele Ziegler
A5062338037- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Immune Cell Function and Interaction
- Digestive system and related health
- Celiac Disease Research and Management
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Diet and metabolism studies
- T-cell and B-cell Immunology
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Infant Nutrition and Health
- Immunodeficiency and Autoimmune Disorders
- Adipose Tissue and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Neonatal Respiratory Health Research
- Breastfeeding Practices and Influences
- Gut microbiota and health
- Adolescent and Pediatric Healthcare
- Bariatric Surgery and Outcomes
- Vitamin D Research Studies
Helmholtz Zentrum München
2016-2025
Klinikum rechts der Isar
2016-2025
Institute of Diabetes Research
2015-2025
Technical University of Munich
2016-2025
Center for Environmental Health
2011-2024
German Center for Diabetes Research
2012-2023
Heinrich Heine University Düsseldorf
2016-2023
Deutsches Diabetes-Zentrum e.V.
2016-2023
Wellcome/MRC Institute of Metabolic Science
2022
University of Cambridge
2022
The temporal development of autoantibodies was studied in 1,353 offspring parents with type 1 diabetes. Islet cell antibodies (ICAs) and to insulin (IAAs), glutamic acid decarboxylase, IA-2 were measured at birth, 9 months, 2 years, 5 years age. At no had islet autoimmunity other than maternally acquired antibodies, which shown influence antibody prevalence up age 6 months. Antibodies detected thereafter likely represent a true de novo production, since prevalences the same for from mothers...
Teplizumab treatment of nondiabetic relatives at high risk for T1D induces partially exhausted CD8 + T cells and improves beta cell function.
OBJECTIVE This study evaluated the long-term safety and efficacy of dapagliflozin as an adjunct to adjustable insulin in patients with type 1 diabetes inadequate glycemic control. RESEARCH DESIGN AND METHODS DEPICT-1 (Dapagliflozin Evaluation Patients With Inadequately Controlled Type Diabetes) was a randomized (1:1:1), double-blind, placebo-controlled phase 3 5 mg 10 (HbA1c 7.5–10.5% [58–91 mmol/mol]) (NCT02268214). The results 52-week study, consisting 24-week short-term 28-week extension...
Public health screening for type 1 diabetes in its presymptomatic stages may reduce disease severity and burden on a population level.To determine the prevalence of children participating public program islet autoantibodies risk progression to clinical diabetes.Screening was offered aged 1.75 5.99 years Bavaria, Germany, between 2015 2019 by primary care pediatricians during well-baby visits. Families with multiple (presymptomatic diabetes) were invited participate education, metabolic...
OBJECTIVE Previous studies showed that inhibiting lymphocyte costimulation reduces declining β-cell function in individuals newly diagnosed with type 1 diabetes. We tested whether abatacept would delay or prevent progression of diabetes from normal glucose tolerance (NGT) to abnormal (AGT) and the effects treatment on immune metabolic responses. RESEARCH DESIGN AND METHODS conducted a phase 2, randomized, placebo-controlled, double-masked trial antibody-positive participants NGT who received...
Human macrophage-like accessory cells were analyzed as they emerge in the absence of extrinsic antigens during fetal development. Monoclonal antibodies to monocytes/macrophages used combination with HLA class II molecules. In yolk sac and mesenchyme sampled at wk 4 6 fertilization age, dendritic morphology formed two populations distinguishable by phenotypic criteria: type i (majority) carried both macrophage-associated (RFD7+) monocyte-associated markers (UCHM1+) but no detectable HLA-DR...
OBJECTIVE A pilot study suggested that combination therapy with low-dose anti-thymocyte globulin (ATG) and pegylated granulocyte colony-stimulating factor (GCSF) preserves C-peptide in established type 1 diabetes (T1D) (duration 4 months to 2 years). We hypothesized 1) ATG/GCSF or 2) ATG alone would slow the decline of β-cell function patients new-onset T1D <100 days). RESEARCH DESIGN AND METHODS three-arm, randomized, double-masked, placebo-controlled trial was performed by Type...
OBJECTIVE We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression islet autoimmunity and T1D in at-risk individuals. RESEARCH DESIGN AND METHODS studied 1,244 TrialNet Pathway Prevention study participants (T1D patients’ relatives without with one or more positive autoantibodies) who were genotyped Illumina ImmunoChip (median [range] age at initial autoantibody determination 11.1 years [1.2–51.8], 48% male, 80.5% non-Hispanic white, median follow-up...
Abstract Immune tolerance is executed partly by Foxp3 + regulatory T (Treg) cells, which suppress autoreactive cells. In autoimmune type 1 diabetes (T1D) impaired promotes destruction of insulin-producing β-cells. The development autoantigen-specific vaccination strategies for Treg-induction and prevention islet autoimmunity in patients still its infancy. Here, using human haematopoietic stem cell-engrafted NSG-HLA-DQ8 transgenic mice, we provide direct evidence vivo . We identify...
The development of anti-islet cell autoimmunity precedes clinical type 1 diabetes and occurs very early in life. During this period, dietary factors strongly impact on the composition gut microbiome. At same time, microbiome plays a central role infant immune system. A functional model association between diet, microbial communities, can provide important new insights regarding pathogenesis diabetes. novel approach was developed to enable analysis an aggregation level single taxon classical...
The POInT study, an investigator initiated, randomised, placebo-controlled, double-blind, multicentre primary prevention trial is conducted to determine whether daily administration of oral insulin, from age 4.0 months 7.0 until 36.0 children with elevated genetic risk for type 1 diabetes, reduces the incidence beta-cell autoantibodies and diabetes.Infants aged Germany, Poland, Belgium, UK Sweden are eligible if they have a >10.0% expected developing multiple as determined by score or family...
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at time stage 3 type 1 diabetes diagnosis, and emerging availability therapy delay disease progression, programmes are being increasingly emphasised. Once broadly implemented, initiatives will identify significant numbers islet autoantibody-positive (IAb
Introduction The identification of type 1 diabetes at an early presymptomatic stage has clinical benefits. These include a reduced risk diabetic ketoacidosis (DKA) the manifestation disease and significant reduction in symptoms. European action for Diagnosis Early Non-clinical Type For Interception (EDENT1FI) represents pioneering effort to advance detection through public health screening. With EDENT1FI Master Protocol, project aims harmonise standardise screening early-stage care. Methods...
Glutamic acid decarboxylase (GAD) has been defined as a major target antigen in insulin-dependent diabetes mellitus (IDDM). To identify the molecular ligands triggering T cell response to GAD, panel of human GAD65-specific lymphocyte lines was generated from peripheral blood three recent onset IDDM patients. All derived patient expressing high-risk-conferring HLA-DR*0301/ *0401 haplotypes recognized single epitope localized between amino positions 270 and 283 GAD65, stretch that is located...
OBJECTIVE: Environmental factors have been suggested to play an important role in the pathogenesis of type 1 diabetes. The aim this study was assess influence breast-feeding, vaccinations, and childhood viral diseases on initiation islet autoimmunity early childhood. RESEARCH DESIGN AND METHODS: Data were prospectively collected from questionnaires obtained at birth, 9 months age, 2 years age 823 offspring parents with By 31 had antibodies, 10 developed overt diabetes by time follow-up....