David N. O’Neal
A5053193359- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Food composition and properties
- Digestive system and related health
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Retinal Diseases and Treatments
- Advanced Glycation End Products research
- Cardiovascular Health and Disease Prevention
- Mobile Health and mHealth Applications
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Gestational Diabetes Research and Management
- Primary Care and Health Outcomes
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Wireless Body Area Networks
The University of Melbourne
2016-2025
St Vincent's Hospital
2016-2025
C. S. Mott Children's Hospital
2025
University of Michigan–Ann Arbor
2025
Saint Vincent's Catholic Medical Center
2009-2024
Mayo Clinic
2024
WinnMed
2024
Austin Health
2024
RMIT University
2023-2024
The University of Sydney
2015-2023
Abstract The significant and growing global prevalence of diabetes continues to challenge people with (PwD), healthcare providers, payers. While maintaining near-normal glucose levels has been shown prevent or delay the progression long-term complications diabetes, a proportion PwD are not attaining their glycemic goals. During past 6 years, we have seen tremendous advances in automated insulin delivery (AID) technologies. Numerous randomized controlled trials real-world studies that use AID...
OBJECTIVE This study evaluated the long-term safety and efficacy of dapagliflozin as an adjunct to adjustable insulin in patients with type 1 diabetes inadequate glycemic control. RESEARCH DESIGN AND METHODS DEPICT-1 (Dapagliflozin Evaluation Patients With Inadequately Controlled Type Diabetes) was a randomized (1:1:1), double-blind, placebo-controlled phase 3 5 mg 10 (HbA1c 7.5–10.5% [58–91 mmol/mol]) (NCT02268214). The results 52-week study, consisting 24-week short-term 28-week extension...
Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful assisting with basic clinical interpretation CGM data. Methods: We assembled a data set 14-day 225 insulin-treated adults diabetes. Using balanced incomplete block design, 330 clinicians who were highly experienced analysis and ranked best to worst glycemia. used principal component multiple regressions develop model predict clinician ranking based on seven standard...
The role of adiponectin, tumour necrosis factor alpha (TNFalpha), leptin and C-reactive protein in the insulin resistance pregnancy is not clear. We measured their levels women with gestational diabetes (GDM) controls, during after pregnancy, related them to secretion action.Nineteen GDM 19 BMI-matched healthy pregnant underwent intravenous glucose tolerance tests third trimester 4 months postpartum determine sensitivity (SI) secretion. Adiponectin, TNFalpha, high CRP (hsCRP) were fasted...
OBJECTIVE To investigate glycemic and psychosocial outcomes with hybrid closed-loop (HCL) versus user-determined insulin dosing multiple daily injections (MDI) or pump (i.e., standard therapy for most adults type 1 diabetes). RESEARCH DESIGN AND METHODS Adults diabetes using MDI without continuous glucose monitoring (CGM) were randomized to 26 weeks of HCL (Medtronic 670G) continuation current therapy. The primary outcome was masked CGM time in range (TIR; 70–180 mg/dL) during the final 3...
This article is the work product of Continuous Glucose Monitor and Automated Insulin Dosing Systems in Hospital Consensus Guideline Panel, which was organized by Diabetes Technology Society met virtually on April 23, 2020. The guideline panel consisted 24 international experts use continuous glucose monitors (CGMs) automated insulin dosing (AID) systems representing adult endocrinology, pediatric obstetrics gynecology, advanced practice nursing, diabetes care education, clinical chemistry,...
Diabetic ketoacidosis (DKA) has been associated with the use of sodium glucose cotransporter 2 inhibitors (SGLT2is). To determine incidence, characteristics, and outcomes DKA in SGLT2i users vs nonusers type diabetes. Retrospective, multicenter, controlled cohort study. All public hospitals Melbourne Geelong (combined population 5 million), Australia, from 1 September 2015 to 31 October 2017. Consecutive cases that developed community, or during course hospital admission, patients diabetes...
<h3>Importance</h3> Hybrid closed-loop (HCL) therapy has improved glycemic control in children and adolescents with type 1 diabetes; however, the efficacy of HCL on psychosocial outcomes not yet been established a long-term randomized clinical trial. <h3>Objective</h3> To determine percentage time spent target glucose range using vs current conventional therapies continuous subcutaneous insulin infusion or multiple daily injections without monitoring (CGM). <h3>Design, Setting,...
We compared glycemia, treatment satisfaction, sleep quality, and cognition using a nighttime Android-based hybrid closed-loop system (Android-HCLS) with sensor-augmented pump low-glucose suspend function (SAP-LGS) in people type 1 diabetes.An open-label, prospective, randomized crossover study of 16 adults (mean [SD] age 42.1 [9.6] years) 12 adolescents (15.2 [1.6] was conducted. All participants completed four consecutive nights at home Android-HCLS (proportional integral derivative insulin...
OBJECTIVE To assess the efficacy and safety of closed-loop insulin delivery compared with sensor-augmented pump therapy among older adults type 1 diabetes. RESEARCH DESIGN AND METHODS This open-label, randomized (1:1), crossover trial 4 months versus therapy. Eligible were aged ≥60 years, diabetes (duration ≥10 years), using an pump. The primary outcome was continuous glucose monitoring (CGM) time in range (TIR; 3.9–10.0 mmol/L). RESULTS There 30 participants (mean age 67 [SD 5] median...
Regular exercise is essential to overall cardiovascular health and well-being in people with type 1 diabetes, but can also lead increased glycemic disturbances. Automated insulin delivery (AID) technology has been shown modestly improve time range (TIR) adults diabetes significantly TIR youth diabetes. Available AID systems still require some user-initiated changes the settings and, cases, significant pre-planning for exercise. Many recommendations were developed initially using multiple...
The physical and psychological benefits of exercise are particularly pertinent to people with type 1 diabetes (T1D). variability in subcutaneous insulin absorption the delay offset onset glucose lowering action impose limitations, given rapidly varying requirements exercise. Simultaneously, there challenges monitoring. Consequently, those T1D less likely because concerns regarding instability. While control can be enhanced using automated delivery (AID), all commercially available AID...
An error grid compares measured versus reference glucose concentrations to assign clinical risk values observed errors. Widely used grids for blood monitors (BGMs) have limited value because they do not also reflect accuracy of continuous (CGMs).
Objective To compare the effectiveness of a novel model care ("Stepping Up") with usual primary in normalising insulin initiation for type 2 diabetes, leading to improved glycated haemoglobin (HbA1c) levels.Design Cluster randomised controlled trial.Setting Primary practices Victoria, Australia, practice nurse and at least one consenting eligible patient (HbA1c ≥7.5% maximal oral treatment).Participants 266 patients diabetes 74 (mean cluster size 4 (range 1-8) patients), followed up 12...
Background: We aimed to compare closed-loop glucose control for people with type 1 diabetes undertaking high-intensity interval exercise (HIIE) versus moderate-intensity (MIE). Methods: Adults established on insulin pumps undertook HIIE and MIE stages in random order during automated delivery via a system (Medtronic). Frequent venous sampling glucose, lactate, ketones, insulin, catecholamines, cortisol, growth hormone, glucagon levels was performed. The primary outcome plasma <4.0 mmol/L ≥15...
Abstract Background: The continuous glucose monitoring system (CGMS) is a novel tool to assess 24‐h fluctuations. In pregnancies complicated by diabetes, where excellent control desired improve maternal and fetal outcomes, CGMS may have role in fine‐tuning management. Aims: To the usefulness of pregnant women with diabetes for medical decision‐making evaluate patient tolerability perception usefulness. Methods: Pregnant at Werribee Mercy Hospital were offered setting their standard care....