A5091135967- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Diabetes Management and Research
- Genetic Associations and Epidemiology
- Heart Rate Variability and Autonomic Control
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Retinal Imaging and Analysis
- Cardiovascular Disease and Adiposity
- Retinal Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Health disparities and outcomes
- Lipoproteins and Cardiovascular Health
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- Diabetes and associated disorders
- Cardiac Imaging and Diagnostics
- Chronic Disease Management Strategies
University College London
2016-2025
MRC Unit for Lifelong Health and Ageing
2012-2025
Imperial College London
2015-2024
Medical Research Council
2012-2024
Williams (United Kingdom)
2024
University of Leicester
2024
University of California, San Diego
2023
Manufacturing Advocacy & Growth Network (United States)
2023
University of London
1995-2022
First Light Fusion
2021
<h2>Summary</h2><h3>Background</h3> One of the global targets for non-communicable diseases is to halt, by 2025, rise in age-standardised adult prevalence diabetes at its 2010 levels. We aimed estimate worldwide trends diabetes, how likely it countries achieve target, and changes prevalence, together with population growth ageing, are affecting number adults diabetes. <h3>Methods</h3> pooled data from population-based studies that had collected on through measurement biomarkers. used a...
This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes chronic kidney disease, or both.In a double-blind fashion, we randomly assigned 8561 (300 mg daily) placebo as an adjunct angiotensin-converting-enzyme angiotensin-receptor blocker. The primary end point composite time death first occurrence cardiac arrest resuscitation; nonfatal myocardial infarction; stroke; unplanned...
Other than glycemic control, there are no treatments for diabetic neuropathy. Thus, identifying potentially modifiable risk factors neuropathy is crucial. We studied the development of distal symmetric in 1172 patients with type 1 diabetes mellitus from 31 centers participating European Diabetes (EURODIAB) Prospective Complications Study.
Background— High-throughput profiling of circulating metabolites may improve cardiovascular risk prediction over established factors. Methods and Results— We applied quantitative nuclear magnetic resonance metabolomics to identify the biomarkers for incident disease during long-term follow-up. Biomarker discovery was conducted in National Finnish FINRISK study (n=7256; 800 events). Replication incremental assessed Southall Brent Revisited (SABRE) (n=2622; 573 events) British Women’s Health...
Abstract The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden possible causes in community, we coordinated analyses survey data from 6907 self-reported COVID-19 10 UK longitudinal study (LS) samples 1.1 million diagnostic codes electronic healthcare records (EHR) collected by spring 2021. Proportions presumed cases LS reporting any symptoms for 12+ weeks ranged 7.8% 17% (with 1.2 to 4.8%...
<h2>Summary</h2><h3>Background</h3> COVID-19 has disproportionately affected minority ethnic populations in the UK. Our aim was to quantify differences SARS-CoV-2 infection and outcomes during first second waves of pandemic England. <h3>Methods</h3> We conducted an observational cohort study adults (aged ≥18 years) registered with primary care practices England for whom electronic health records were available through OpenSAFELY platform, who had at least 1 year continuous registration start...
BackgroundEthnicity recording across the National Health Service (NHS) has improved dramatically over past decade. This study profiles completeness, consistency and representativeness of routinely collected ethnicity data in both primary care hospital settings.
Objectives UK Biobank is a UK-wide cohort of 502,655 people aged 40–69, recruited from National Health Service registrants between 2006–10, with healthcare data linkage. Type 2 diabetes key exposure and outcome. We developed algorithms to define prevalent incident for Biobank. The will be implemented by their results made available researchers on request. Methods used self-reported medical history medication assign type, tested this against linked primary secondary care in Welsh...
Abnormalities of the retinal microcirculation are found in hypertension and diabetes predict cardiovascular mortality. This study examined relationship between abnormalities microvasculature death from ischemic heart disease (IHD) stroke. A population-based, nested case-control was undertaken within Beaver Dam Eye Study. Subjects (43 to 74 years) who died IHD (n=126) or stroke (n=28) over a 10-year period were age gender matched with controls subjects (n=528; case:control matching, ≈1:4)....
<b>Background:</b> The associations of body mass index (BMI) and chronic disease may differ between Indo-Asian Western populations. We used Indo-Asian-specific definitions overweight obesity to determine the prevalence these problems in Pakistan studied sensitivity specificity BMI cutoff values for an association with hypertension diabetes mellitus. <b>Methods:</b> analyzed data 8972 people aged 15 years or more from National Health Survey (1990–1994). People considered obese were those a 23...
Background. Patients with type 2 diabetes are at increased risk of macro- and microvascular disease, the presence albuminuria and/or reduced kidney function further enhances macrovascular risk. Angiotensin-converting-enzyme inhibitors reduce both events, yet residual renal cardiovascular still remains high. Aliskiren a novel oral direct renin inhibitor that unlike ACEi ARBs, lowers plasma activity, angiotensin I II levels, may thereby provide greater benefit compared to or ARB alone.
DNA methylation is strongly associated with smoking status at multiple sites across the genome. Studies have largely been restricted to European origin individuals yet greatest increase in occurring low income countries, such as Indian subcontinent. We determined whether there are differences between South Asians and Europeans related loci, if a score, combining all scores, could differentiate smokers from non-smokers. Illumina HM450k BeadChip arrays were performed on 192 samples Southall...
This study sought to determine whether ethnic differences in diabetes, dyslipidemia, and ectopic fat deposition account for incident cardiovascular disease.Coronary heart disease risks are elevated South Asians lower African Caribbeans compared with Europeans. These map lipid patterns deposition.Cardiovascular risk factors were assessed 2,049 Europeans, 1,517 Asians, 630 from 1988 through 1991 (mean age: 52.4 ± 6.9 years). Fatal nonfatal events captured over a median 20.5-year follow-up....
BackgroundThe 2016 Dar Es Salaam Call to Action on Diabetes and Other non-communicable diseases (NCDs) advocates national multi-sectoral NCD strategies action plans based available data information from countries of sub-Saharan Africa beyond. We estimated trends 1980 2014 in age-standardized mean body mass index (BMI) diabetes prevalence these countries, order assess the co-progression assist policy formulation.
Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a prothrombotic state, but long-term effects of COVID-19 on incidence vascular diseases are unclear. Methods: We studied after diagnosis in population-wide anonymized linked English and Welsh electronic health records from January 1 to December 7, 2020. estimated adjusted hazard ratios comparing the arterial thromboses venous thromboembolic events (VTEs) people without diagnosis. conducted...
South Asian individuals have an increased risk of diabetes compared with Europeans that is unexplained by obesity and traditional or established metabolic measures. Circulating amino acids (AAs) may provide additional explanatory insights. In a unique cohort European men, we cross-sectional associations between AAs, traits, longitudinal incident diabetes. Nuclear magnetic spectroscopy was used to measure the baseline (1988–1991) levels nine AAs in serum samples from British population-based...