A5089366070- Global Public Health Policies and Epidemiology
- Salmonella and Campylobacter epidemiology
- Tuberculosis Research and Epidemiology
- Vibrio bacteria research studies
- Obesity, Physical Activity, Diet
- Mycobacterium research and diagnosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Viral gastroenteritis research and epidemiology
- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Smoking Behavior and Cessation
- Child Nutrition and Water Access
- Blood Pressure and Hypertension Studies
- Antibiotic Resistance in Bacteria
- Nutritional Studies and Diet
- Health disparities and outcomes
- Parasites and Host Interactions
- Healthcare Systems and Reforms
- COVID-19 epidemiological studies
- Syphilis Diagnosis and Treatment
- Chronic Disease Management Strategies
- Birth, Development, and Health
- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
Kwame Nkrumah University of Science and Technology
2016-2025
Kwame Nkrumah University
2008-2024
University of Bayreuth
2024
Kumasi Centre for Collaborative Research in Tropical Medicine
2014-2023
University of Malawi
2021
Toscana Life Sciences
2021
International Vaccine Institute
2019-2021
University of Cape Coast
2021
Kenya Medical Research Institute
2021
Wellcome Trust
2021
The Framework Convention on Tobacco Control (FCTC), a World Health Organization treaty, has now been ratified by over 165 countries. However there are concerns that implementing the Articles of treaty may prove difficult, particularly in developing world. In this study we have used qualitative methods to explore extent which FCTC implemented Ghana, country was 39th ratify FCTC, and identify barriers effective implementation low income Semi-structured interviews with 20 members national...
BackgroundThe 2016 Dar Es Salaam Call to Action on Diabetes and Other non-communicable diseases (NCDs) advocates national multi-sectoral NCD strategies action plans based available data information from countries of sub-Saharan Africa beyond. We estimated trends 1980 2014 in age-standardized mean body mass index (BMI) diabetes prevalence these countries, order assess the co-progression assist policy formulation.
Introduction: The increasing incidence of infections caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in sub-Saharan Africa is serious concern. Studies from countries with a highly industrialized poultry industry suggest the production-food-consumer chain as potential transmission route. In Africa, integrated studies at this human-animal interface are still missing. Aim: To determine molecular epidemiology ESBL-producing E. intestinal tract humans and rural Ghana....
<h2>Summary</h2><h3>Background</h3> Typhoid Fever remains a major cause of morbidity and mortality in low-income settings. The Severe Africa programme was designed to address regional gaps typhoid burden data identify populations eligible for interventions using novel conjugate vaccines. <h3>Methods</h3> A hybrid design, hospital-based prospective surveillance with population-based health-care utilisation surveys, implemented six countries sub-Saharan Africa. Patients presenting fever...
The human immunity-related GTPase M (IRGM) has been shown to be critically involved in regulating autophagy as a means of disposing cytosolic cellular structures and reducing the growth intracellular pathogens vitro. This includes Mycobacterium tuberculosis, which is agreement with findings indicating that M. tuberculosis translocates from phagolysosome into cytosol infected cells, where it becomes exposed autophagy. To test whether IRGM plays role infection, we studied gene variants 2010...
Rising rates of obesity and type 2 diabetes (T2D) are impending major threats to the health African populations, but extent which they differ between rural urban settings in Africa upon migration Europe is unknown. We assessed burden T2D among Ghanaians living Ghana Ghanaian migrants different European countries.A multi-centre cross-sectional study was conducted adults (n = 5659) aged 25-70 years residing three cities (Amsterdam, London Berlin). Comparisons groups were made using prevalence...
The application of genomics technologies to medicine and biomedical research is increasing in popularity, made possible by new high-throughput genotyping sequencing improved data analysis capabilities. Some the greatest genetic diversity among humans, animals, plants, microbiota occurs Africa, yet genomic outputs from continent are limited. Human Heredity Health Africa (H3Africa) initiative was established drive development for human health through recognition critical role bioinformatics...
There is paucity of data regarding the geographical distribution, incidence, and phylogenetics multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction whole genome sequenced 249 contemporaneous S. isolated between 2008-2015 11 African countries, context 2,057 global genomic framework. Despite broad genetic diversity, majority organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), 2.3.2...
Introduction Obesity and type 2 diabetes (T2D) are highly prevalent among African migrants compared with European descent populations. The underlying reasons still remain a puzzle. Gene–environmental interaction is now seen as potential plausible factor contributing to the high prevalence of obesity T2D, but has not yet been investigated. overall aim R esearch on O besity D iabetes A frican M igrants (RODAM) project understand for T2D sub-Saharan Africans in diaspora by (1) studying complex...
Background : West African immigrants in Europe are disproportionally affected by metabolic conditions compared to European host populations. Nutrition transition through urbanisation and migration may contribute this observations, but remains be characterised. Objective We aimed describe the dietary behaviour its socio-demographic factors among Ghanaian migrants their compatriots living different settings. Methods The multi-centre, cross-sectional RODAM (Research on Obesity Diabetes...
BackgroundThe incidence of enteric fever, an invasive bacterial infection caused by typhoidal Salmonellae (Salmonella enterica serovars Typhi and Paratyphi), is largely unknown in regions without blood culture surveillance. The aim this study was to evaluate whether new diagnostic serological markers for Salmonella can reliably estimate population-level incidence.MethodsWe collected longitudinal samples from patients with culture-confirmed fever enrolled surveillance studies Bangladesh,...
To investigate differences in overweight and obesity between first-generation Dutch-Ghanaian migrants The Netherlands their rural urban counterparts Ghana.Cross-sectional study.A total of 1471 Ghanaians (rural Ghanaians, n 532; 787; Dutch-Ghanaians, 152) aged > or = 17 years.Overweight (BMI 25 kg/m2) 30 kg/m2).Dutch-Ghanaians had a significantly higher prevalence (men 69.1%, women 79.5%) than 22.0%, 50.0%) 10.3%, 19.0%). Urban Ghanaian men also counterparts. In logistic regression analysis...
Type 2 diabetes (T2D) results from a complex interplay between genetics and the environment. Several epigenome-wide association studies (EWAS) have found DNA methylation loci associated with T2D in European populations. However, data African populations are lacking. We undertook first EWAS for among sub-Saharan Africans, aiming at identifying ubiquitous novel T2D.
Epigenome-wide association studies (EWAS) have identified DNA methylation loci involved in adiposity. However, EWAS on adiposity sub-Saharan Africans are lacking despite the high burden of among African populations. We undertook an for anthropometric indices Ghanaians aiming to identify that significantly associated. The Illumina 450k array was used profile whole blood samples 547 from Research Obesity and Diabetes Migrants (RODAM) study. Differentially methylated positions (DMPs)...
Abstract Objective The Middle East respiratory syndrome coronavirus (MERS‐CoV) emerged in 2012 on the Arabian Peninsula and has caused severe disease with more than 800 laboratory‐confirmed cases. return of infected pilgrims to their home countries a putative spread MERS‐CoV necessitates further surveillance. Methods A cross sectional study 839 adult African Hajj returning Accra Ghana, West Africa, was conducted 2013 assess prevalence symptoms as well MERS‐CoV, human rhinovirus (HRV),...
Hypertension is a major burden among African migrants, but the extent of differences in prevalence, treatment, and control similar migrants nonmigrants living different contexts high-income countries rural urban Africa has not yet been assessed. We assessed hypertension prevalence its management relatively homogenous (Ghanaians) three European cities (Amsterdam, London, Berlin) Ghana.A multicenter cross-sectional study was conducted Ghanaian adults (n = 5659) aged 25-70 years. Comparisons...
Yearly, tobacco use kills about 8 million people globally, 80% of whom live in low/middle-income countries. Given sub-Saharan Africa's (SSA) rapidly increasing and youthful population, growing incomes the increased presence industry, number users is growing. The region predicted to face a heavier burden tobacco-related diseases deaths future. We examined policy, advocacy, economic media landscapes control as well industry interference SSA. also highlighted key challenges priorities for...