A5077160522- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Impact and Responses
- HIV Research and Treatment
- Global Maternal and Child Health
- HIV-related health complications and treatments
- Poverty, Education, and Child Welfare
- HIV/AIDS drug development and treatment
- Child Nutrition and Water Access
- Data-Driven Disease Surveillance
- Tuberculosis Research and Epidemiology
- Mobile Health and mHealth Applications
- COVID-19 epidemiological studies
- Global Public Health Policies and Epidemiology
- Sex work and related issues
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Health disparities and outcomes
- Urban Transport and Accessibility
- Malaria Research and Control
- Mosquito-borne diseases and control
- Blood Pressure and Hypertension Studies
- Global Health Care Issues
- Parasites and Host Interactions
Stellenbosch University
2022-2025
Africa Health Research Institute
2013-2024
University of KwaZulu-Natal
2015-2024
Centre for the AIDS Programme of Research in South Africa
2016-2024
Response Biomedical (Canada)
2024
University of Lincoln
2019-2023
University of Zululand
2023
University of Waterloo
2022
Lincoln University - Pennsylvania
2022
University College London
2016-2021
The landmark HIV Prevention Trials Network (HPTN) 052 trial in HIV-discordant couples demonstrated unequivocally that treatment with antiretroviral therapy (ART) substantially lowers the probability of transmission to HIV-uninfected partner. However, it has been vigorously debated whether substantial population-level reductions rate new infections could be achieved "real-world" sub-Saharan African settings where stable, cohabiting are often not norm and considerable operational challenges...
HIV/AIDS is a leading cause of disease burden in sub-Saharan Africa. Existing evidence has demonstrated that there substantial local variation the prevalence HIV; however, subnational not been investigated at high spatial resolution across continent. Here we explore within-country 5 × 5-km Africa by estimating HIV among adults (aged 15–49 years) and corresponding number people living with from 2000 to 2017. Our analysis reveals throughout differences both direction rate change between 2017,...
The health and demography of the South African population has been undergoing substantial changes as a result rapidly progressing HIV epidemic. Researchers at University KwaZulu-Natal Medical Research Council established Africa Centre for Health Population Studies in 1997 funded by large core grant from Wellcome Trust, UK. Given urgent need high quality longitudinal data with which to monitor these changes, evaluate interventions mitigate impact, demographic surveillance system (DSS) was...
BackgroundThe 2016 Dar Es Salaam Call to Action on Diabetes and Other non-communicable diseases (NCDs) advocates national multi-sectoral NCD strategies action plans based available data information from countries of sub-Saharan Africa beyond. We estimated trends 1980 2014 in age-standardized mean body mass index (BMI) diabetes prevalence these countries, order assess the co-progression assist policy formulation.
SARS-CoV-2 across Africa The impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been hard to track in African countries, largely because patchy data. Wilkinson et al . curated viral genomes collected 2021 from several countries continent. Outbreaks during 2020 each country were initiated by imported cases, mostly Europe. As developed, case numbers likely many times higher than reported, and subsequent waves appear have more severe. Consequently,...
BackgroundThere has been remarkable progress in the treatment of HIV throughout sub-Saharan Africa, but there are few data on prevalence and overlap other significant causes disease endemic populations. Our aim was to identify infectious non-communicable diseases such a population rural South Africa.MethodsWe did cross-sectional study eligible adolescents adults from Africa Health Research Institute demographic surveillance area uMkhanyakude district KwaZulu-Natal, Africa. The participants,...
South Africa contains more than one in seven of the world's HIV-positive population. Knowledge local variation levels HIV infection is important for prioritization areas intervention. We apply two spatial analytical techniques to investigate micro-geographical patterns and clustering infections a high prevalence, rural population KwaZulu-Natal, Africa.All 12,221 participants who consented an test under continuous demographical surveillance were linked their homesteads geo-located...
To investigate trends in adult mortality a population serviced by public-sector antiretroviral therapy (ART) programme rural South Africa using demographic surveillance system.Verbal autopsies were conducted for all 7930 deaths observed between January 2000 and December 2006 of 74,500 the Umkhanyakude district northern KwaZulu-Natal province, Africa. Age-standardized rate ratios (SMRRs) calculated adults aged 25 to 49 years, group most affected HIV, 2 years before 2004 3 subsequent during...
Antiretroviral treatment (ART) coverage is rapidly expanding in sub-Saharan Africa (SSA). Based on the effect of ART survival HIV-infected people and HIV transmission, age composition epidemic region expected to change coming decades. We quantify all countries SSA.
Objectives: To investigate HIV prevalence trends in a rural South African community after the scale-up of antiretroviral treatment (ART) 2004. Methods: We estimated adult (ages 15–49 years) using data from large, longitudinal, population-based surveillance KwaZulu-Natal, Africa, over period 2004 (the year when public-sector ART started) to 2011. control for selection effects due nonparticipation multiple imputation. further linked patient records local program estimate coverage. Results:...
Background The 2015 WHO recommendation of antiretroviral therapy (ART) for all immediately following HIV diagnosis is partially based on the anticipated impact incidence in surrounding population. We investigated this approach a cluster-randomised trial high prevalence setting rural KwaZulu-Natal. present findings from first phase and report uptake home-based testing, linkage to care, ART, community attitudes about ART. Methods Findings Between 9 March 2012 22 May 2014, five clusters...
Using nine structurally different models, Jan Hontelez and colleagues investigate timeframes for HIV elimination in South Africa using a universal test treat strategy. Please see later the article Editors' Summary
Background Women have better patient outcomes in HIV care and treatment than men sub-Saharan Africa. We assessed—at the population level—whether to what extent mass is associated with changes sex disparities adult life expectancy, a summary metric of survival capturing mortality across full cascade care. also determined sex-specific trends distribution HIV-related deaths women prior at each stage clinical cascade. Methods Findings Data were collected on all occurring from 2001 2011 large...
Abstract Over the past decade, there has been a massive scale-up of primary and secondary prevention services to reduce population-wide incidence HIV. However, impact these on HIV not demonstrated using prospectively followed, population-based cohort from South Africa—the country with world’s highest rate new infections. To quantify trends in hyperendemic population, we tested 22,239 uninfected participants over 92,877 person-years observation. We report 43% decline overall between 2012...
Antiretroviral therapy (ART) suppresses HIV viral load in all body compartments and so limits the risk of transmission. It has been suggested that ART not only contributes to preventing transmission at individual but potentially also population level. This trial aims evaluate effect initiated immediately after identification/diagnosis HIV-infected individuals, regardless CD4 count, on incidence surrounding population. The primary outcome overall will be over two years. Secondary outcomes...
Background: Based on ethnographic investigations and mathematical models, older sexual partners are often considered a major risk factor for HIV young women in sub-Saharan Africa. Numerous public health campaigns have been conducted to discourage from relationships with men. However, longitudinal evidence relating sex partner age disparity acquisition is limited. Methods: Using data population-based open cohort rural KwaZulu-Natal, South Africa, we studied 15- 29-year-old who were...
Antiretroviral therapy for HIV may have important economic benefits patients and their households. We quantified the impact of treatment on employment status among in rural South Africa who were enrolled a public-sector program supported by President's Emergency Plan AIDS Relief. linked clinical data from more than 2,000 with ten years longitudinal socioeconomic complete community-based population cohort 30,000 adults residing catchment area. estimated effects fixed-effects regressions. Four...