A5025168799- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- vaccines and immunoinformatics approaches
- Viral Infections and Outbreaks Research
- SARS-CoV-2 detection and testing
- Immune responses and vaccinations
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- COVID-19 diagnosis using AI
- COVID-19 Clinical Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Vector-borne infectious diseases
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Food Safety and Hygiene
- Urban Transport and Accessibility
- Full-Duplex Wireless Communications
- Pneumonia and Respiratory Infections
- Climate Change Policy and Economics
- Animal Virus Infections Studies
- Respiratory viral infections research
- COVID-19 Pandemic Impacts
Robert Koch Institute
2021-2024
Université Paris Cité
2024
Institut Pasteur
2012-2024
Inserm
2016-2024
Infectious Disease Models and Innovative Therapies
2015-2024
Université Paris-Saclay
2015-2024
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2014-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2014-2024
CEA Paris-Saclay
2024
Université Paris-Sud
2015-2019
SARS-CoV-2 across Africa The impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been hard to track in African countries, largely because patchy data. Wilkinson et al . curated viral genomes collected 2021 from several countries continent. Outbreaks during 2020 each country were initiated by imported cases, mostly Europe. As developed, case numbers likely many times higher than reported, and subsequent waves appear have more severe. Consequently,...
Chikungunya virus (CHIKV) is a reemerging, ordinarily mosquito-transmitted, alphavirus that occasionally produces hemorrhagic manifestations, such as nose bleed and bleeding gums, in human patients. Interferon response factor 3 7 deficient (IRF3/7-/-) mice, which are for interferon α/β responses, reliably develop manifestations after CHIKV infection. Here we show infectious was present the oral cavity of infected IRF3/7-/- likely due to lesions olfactory epithelium allow egress blood into...
Abstract The progression of the SARS-CoV-2 pandemic in Africa has so far been heterogeneous and full impact is not yet well understood. Here, we describe genomic epidemiology using a dataset 8746 genomes from 33 African countries two overseas territories. We show that epidemics most were initiated by importations, predominantly Europe, which diminished following early introduction international travel restrictions. As progressed, ongoing transmission many increasing mobility led to emergence...
Abstract First isolated in 1953 Tanzania, the arthritogenic Chikungunya virus (CHIKV) re-emerged globally 2005, leading to widespread outbreaks. Unlike other arboviruses, CHIKV predominantly induces symptomatic infections (72-96%), marked by fever, myalgia, polyarthralgia, and rash. Although rarely fatal, atypical forms such as encephalopathies can occur. Notably, 75.4% of patients experience persistent arthralgias for up three years after acute phase. Understanding CHIKV’s pathophysiology...
Abstract Background In sub-Saharan Africa, acute respiratory infections (ARI), gastrointestinal (GI) and febrile disease of unknown cause (AFDUC) have a large burden, especially among children, while respective aetiologies often remain unresolved. The need for robust infectious surveillance to detect emerging pathogens along with common human has been highlighted by the ongoing novel coronavirus 2019 (COVID-19) pandemic. African Network Improved Diagnostics, Epidemiology Management Common...
Background The essential oils of Cymbopogon citratus (CC), Pelargonium graveolens (PG) and Vetiveria zizanioides (VZ) are commonly used topically to prevent mosquito bites thus the risk infection by their vectored pathogens such as arboviruses. However, since not fully prevented, effect these products on level viral remains unknown. Objectives To evaluate in vitro essentials from Reunion Island against one archetypal arbovirus, Ross River virus (RRV), investigate cycle step that was impaired...
Arboviruses like chikungunya and Ross River (RRV) are responsible for massive outbreaks of viral polyarthritis. There is no effective treatment or vaccine available against these viruses that induce prolonged disabling arthritis. To explore the physiopathological mechanisms alphaviral arthritis, we engineered a recombinant RRV expressing NanoLuc reporter (RRV-NLuc), which exhibited high stability, near native replication kinetics allowed real time monitoring spread in an albino mouse strain....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased transmissibility, virulence and immune escape abilities have heavily altered the COVID-19 pandemic's course. Deciphering local global transmission patterns of those is thus key in building a profound understanding virus' spread around globe. In present study, we investigate SARS-CoV-2 variant epidemiology Côte d'Ivoire, Western sub-Saharan Africa. We therefore generated 234 full genomes stemming from Central...
Background: After its initial detection in Wuhan, China, December 2019, SARS-CoV-2 has spread rapidly, causing successive epidemic waves worldwide. This study aims to provide a genomic epidemiology of Burkina Faso. Methods: Three hundred and seventy-seven genomes obtained from PCR-positive nasopharyngeal samples (PCR cycle threshold score < 35) collected between 5 May 2020, 31 January 2022 were analyzed. Genomic sequences assigned phylogenetic clades using NextClade Pango lineages...
Abstract Background Reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread across Africa have varied, including among healthcare workers (HCWs). This study assessed the comparative SARS-CoV-2 burden and associated risk factors HCWs in three African countries. Methods A multicentre was conducted at regional facilities Côte d’Ivoire (CIV), Burkina Faso (BF) South (SA) from February to May 2021. provided blood samples for serology nasopharyngeal/oropharyngeal swabs...
Background Viral gastrointestinal infections remain a major public health concern in developing countries. In Burkina Faso, there are very limited updated data on the circulating viruses and their genetic diversity. Objectives This study investigates detection rates characteristics of rotavirus A (RVA), norovirus (NoV), sapovirus (SaV) human astrovirus (HAstV) patients all ages with acute infection urban rural areas. Study design & Methods From 2018 to 2021, stool samples from 1,295...
Campylobacter spp. is a significant etiological agent of bacterial gastroenteritis globally. In Burkina Faso (BFA), the actual impact this pathogen on considerably underestimated, primarily due to inadequate surveillance systems.
Abstract SARS-CoV-2 variants of concern (VOC) and interest (VOI) are heavily altering the COVID-19 pandemic’s course due to their increased transmissibility, virulence immune escape abilities. Data on spread in western sub-Saharan Africa is however still scarce. We therefore sequenced viral genomes from cases identified central northern Côte d’Ivoire between May 2020 March 2021. report introduction VOC B.1.1.7 as early mid-January 2021, followed by detection a single case B.1.351, well VOI...
La propagation rapide du chikungunya d’abord dans les Caraibes (Guadeloupe, Martinique, Saint-Barthelemy, Saint Martin, Dominique…) avec plus de 2500 cas confirmes, puis en Guyane francaise et tout recemment le sud-est Mexique souleve legitimement la question des consequences l’arrivee d’une nouvelle arbovirose majeure l’hemisphere Ouest qui demeurait epargne par maladie [1, 11]. Jusqu’a present, epidemies etaient confinees principalement [...]
Background: After its initial detection in Wuhan, China, December 2019, SARS-CoV-2 has spread rapidly, causing successive epidemic waves worldwide. This study aims to provide a genomic epidemiology of Burkina Faso. Methods: Three hundred and seventy-seven genomes obtained from PCR-positive nasopharyngeal samples (PCR cycle threshold score &lt;35) collected between May 5, 2020, January 31, 2022 were analysed. Genomic sequences assigned phylogenetic clades using NextClade Pango lineages...