A5041313004- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Urinary Tract Infections Management
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Health and Medical Studies
- Infection Control in Healthcare
- Respiratory viral infections research
- Data-Driven Disease Surveillance
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- Pharmaceutical and Antibiotic Environmental Impacts
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Microscopic Colitis
- Mycobacterium research and diagnosis
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial biofilms and quorum sensing
Robert Koch Institute
2016-2025
Institute for Health Metrics and Evaluation
2024
University of Washington
2024
Institute for Regional Studies
2022
Institut Supérieur Agronomique et Vétérinaire Valéry Giscard d'Estaing
2019-2020
World Health Organization
2016-2017
Charité - Universitätsmedizin Berlin
2001-2014
Center for Surveillance, Epidemiology, and Laboratory Services
2012
Society for Healthcare Epidemiology of America
2009
Medizinische Hochschule Hannover
2009
Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed estimate the burden of infections caused by public concern in countries EU European Economic Area (EEA) 2015, measured number cases, deaths, disability-adjusted life-years (DALYs).We estimated incidence with 16 antibiotic resistance-bacterium combinations from Antimicrobial Resistance Surveillance Network...
Estimating the burden of healthcare-associated infections (HAIs) compared to other communicable diseases is an ongoing challenge given need for good quality data on incidence these and involved comorbidities. Based methodology Burden Communicable Diseases in Europe (BCoDE) project 2011-2012 from European Centre Disease Prevention Control (ECDC) point prevalence survey (PPS) HAIs antimicrobial use acute care hospitals, we estimated six common HAIs.The included were pneumonia (HAP), urinary...
Outbreaks of Clostridium difficile infections (CDI) with increased severity, high relapse rate and significant mortality have been related to the emergence a new, hypervirulent C. strain in North America Europe. This emerging is referred as PCR ribotype 027 (Type 027). Since 2005, individual countries developed surveillance studies about spread type 027. Type has reported 16 European countries. It responsible for outbreaks Belgium, Germany, Finland, France, Ireland, Luxembourg, The...
Residents in long-term care facilities (LTCF) are a vulnerable population group. Coronavirus disease (COVID-19)-related deaths LTCF residents represent 30-60% of all COVID-19 many European countries. This situation demands that countries implement local and national testing, infection prevention control, monitoring programmes for order to identify clusters early, decrease the spread within between reduce size severity outbreaks.
Abstract Objectives The COVID-19 pandemic has had a substantial impact on health systems. WHO Antimicrobial Resistance (AMR) Surveillance and Quality Assessment Collaborating Centres Network conducted survey to assess the effects of AMR surveillance, prevention control. Methods From October December 2020, Global Use System (GLASS) national focal points completed questionnaire, including Likert scales open-ended questions. Data were descriptively analysed, income/regional differences assessed...
Objective. To determine the influence Hawthorne effect has on compliance with antiseptic hand rub (AHR) use among healthcare personnel. Design. Observational study. Setting. Five intensive care units of a university hospital in Berlin, Germany. Participants. Medical personnel were monitored 2 periods regarding AHR when there indications for use. In first period, had no knowledge being observed. The second observation period was announced to staff advance and information about what observer...
Background Since the relationship between dogs and their owners has changed, moved from being working to family members in post-industrial countries, we hypothesized that zoonotic transmission of opportunistic pathogens like coagulase positive staphylococci (CPS) is likely owners. Methodology/Principal Findings CPS- nasal carriage, different aspects human-to-dog as well potential interspecies risk factors were investigated by offering swabs a questionnaire dog (108) at show 2009. S. aureus...
Invasive infections with Mycobacterium chimaera were reported in patients previous open chest surgery and exposure to contaminated heater-cooler units (HCUs). We present results of the surveillance clinical cases HCUs as well environmental investigations Germany up until February 2016. Clinical occurred five male German over 50 years age (range 53-80). Cases had been exposed from one single manufacturer during prior onset symptoms. During investigations, M. was detected samples used three...
Introduction To establish strategic priorities for the German national public health institute (RKI) and guide institute's mid-term decisions, we prioritized infectious pathogens in accordance with their importance surveillance epidemiological research. Methods We used Delphi process internal external experts a metric-consensus approach to score according ten three-tiered criteria. Additional were invited weight each criterion, leading calculation of median by which was multiplied. ranked...
Vancomycin-resistant enterococci infections are of great public health significance due to limited therapeutic options. We investigated epidemiological trends and risk factors vancomycin resistance in isolates from patients with bloodstream the EU/EEA 2012 2018. Routine susceptibility data clinical
Abstract Background Antibiotic-resistant Klebsiella pneumoniae are a major cause of hospital- and community-acquired infections, including sepsis, liver abscess, pneumonia, driven mainly by the emergence successful high-risk clonal lineages. The K. sequence type (ST) 307 lineage has appeared in several different parts world after first being described Europe 2008. From June to October 2019, we recorded an outbreak extensively drug-resistant ST307 four medical facilities north-eastern...
The 2013–2016 Ebola outbreak in West Africa is the largest on record with 28 616 confirmed, probable and suspected cases 11 310 deaths officially recorded by 10 June 2016, true burden probably considerably higher. case fatality ratio (CFR: proportion of that are fatal) a key indicator disease severity useful for gauging appropriate public health response evaluating treatment benefits, if estimated accurately. We analysed individual-level clinical outcome data from Guinea, Liberia Sierra...
Background The ongoing West African Ebola epidemic began in December 2013 Guinea, probably from a single zoonotic introduction. As result of ineffective initial control efforts, an outbreak unprecedented scale emerged. 4 May 2015, it had resulted more than 19,000 probable and confirmed cases, mainly Guinea (3,529), Liberia (5,343), Sierra Leone (10,746). Here, we present analyses data collected during the identifying drivers transmission highlighting areas where could be improved. Methods...
Due to limited therapeutic options, vancomycin-resistant Enterococcus faecium (VREF) is of great clinical significance. Recently, rising proportions vancomycin resistance in enterococcal infections have been reported worldwide. This study aims describe current epidemiological trends VREF German hospitals and identify factors that are associated with an increased likelihood E. isolates. 2012 2017 data from routine susceptibility testing 35,906 isolates 148 were analysed using the...
In 2022, German surveillance systems observed rapidly increasing numbers of NDM-1- and NDM-1/OXA-48-producing Klebsiella pneumoniae, which may in part reflect recurring pre-pandemic trends. Among these cases, however, a presence Ukraine before diagnosis was frequently reported. Whole genome sequencing 200 isolates showed high prevalence sequence types ST147, ST307, ST395 ST23, including clusters corresponding to clonal dissemination suggesting onward transmission Germany. Screening isolation...