A5027928189- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Antimicrobial Resistance in Staphylococcus
- Viral gastroenteritis research and epidemiology
- Nosocomial Infections in ICU
- Bacterial Identification and Susceptibility Testing
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Infection Control in Healthcare
- Gastrointestinal motility and disorders
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Urinary Tract Infections Management
- Reproductive tract infections research
- Bacterial biofilms and quorum sensing
- Infection Control and Ventilation
- Mycobacterium research and diagnosis
- Healthcare cost, quality, practices
- Central Venous Catheters and Hemodialysis
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Syphilis Diagnosis and Treatment
- SARS-CoV-2 detection and testing
University of Leeds
2016-2025
Leeds Teaching Hospitals NHS Trust
2016-2025
NIHR Leeds Musculoskeletal Biomedical Research Unit
2024
European Society of Clinical Microbiology and Infectious Diseases
2017-2024
Leeds General Infirmary
2014-2023
UK Health Security Agency
2021-2023
National Health Service
2010-2023
National Institute for Health Research
2023
Manchester University NHS Foundation Trust
2023
University of Oxford
2023
Since publication of the Society for Healthcare Epidemiology America position paper on Clostridium difficile infection in 1995, significant changes have occurred epidemiology and treatment this infection. C. remains most important cause healthcare-associated diarrhea is increasingly as a community pathogen. A more virulent strain has been identified responsible more-severe cases disease worldwide. Data reporting decreased effectiveness metronidazole severe published. Despite increasing...
A panel of experts was convened by the Infectious Diseases Society America (IDSA) and for Healthcare Epidemiology (SHEA) to update 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations children (following adult epidemiology, diagnosis, treatment), includes significant changes management this reflects evolving controversy over best methods diagnosis. remains most important cause healthcare-associated diarrhea...
Abstract A panel of experts was convened by the Infectious Diseases Society America (IDSA) and for Healthcare Epidemiology (SHEA) to update 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations children (following adult epidemiology, diagnosis, treatment), includes significant changes management this reflects evolving controversy over best methods diagnosis. remains most important cause healthcare-associated...
Clostridium difficile is the most common cause of infectious diarrhea in hospitalized patients. Recurrences are after antibiotic therapy. Actoxumab and bezlotoxumab human monoclonal antibodies against C. toxins A B, respectively.We conducted two double-blind, randomized, placebo-controlled, phase 3 trials, MODIFY I II, involving 2655 adults receiving oral standard-of-care antibiotics for primary or recurrent infection. Participants received an infusion (10 mg per kilogram body weight),...
It has been thought that Clostridium difficile infection is transmitted predominantly within health care settings. However, endemic spread hampered identification of precise sources and the assessment efficacy interventions.
In 2009 the first European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guideline for diagnosing Clostridium difficile infection (CDI) was launched. Since then newer tests CDI have become available, especially nucleic acid amplification tests. The main objectives this update guidance document are to summarize currently available evidence concerning laboratory diagnosis formulate revise recommendations optimize testing. This is essential improve uniformity in surveillance...
Abstract This clinical practice guideline is a focused update on management of Clostridioides difficile infection (CDI) in adults specifically addressing the use fidaxomicin and bezlotoxumab for treatment CDI. was developed by multidisciplinary panel representing Infectious Diseases Society America (IDSA) Healthcare Epidemiology (SHEA). intended healthcare professionals who care with CDI, including specialists infectious diseases, gastroenterologists, hospitalists, pharmacists, any...
A robust high-throughput multilocus sequence typing (MLST) scheme for Clostridium difficile was developed and validated using a diverse collection of 50 reference isolates representing 45 different PCR ribotypes 102 from recent clinical samples. total 49 were represented overall. All typed by MLST yielded 40 types (STs). web-accessible database set up (http://pubmlst.org/cdifficile/) to facilitate the dissemination comparison C. genotyping data among laboratories. ribotyping similar in...
Diagnosis of Clostridium difficile infection is controversial because many laboratory methods, compounded by two reference methods. Cytotoxigenic culture detects toxigenic C and gives a positive result more frequently (eg, colonisation, which means that individuals can have the bacterium but no free toxin) than does cytotoxin assay, preformed toxin in faeces. We aimed to validate methods according clinical outcomes derive an optimum diagnostic algorithm for infection.In this prospective,...
In 2009, the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) published first treatment guidance document for Clostridioides difficile infection (CDI). This was updated in 2014. The growing literature on CDI antimicrobial novel approaches, such as faecal microbiota transplantation (FMT) toxin-binding monoclonal antibodies, prompted ESCMID study group C. (ESGCD) to update 2014 adults.Key questions were formulated by guideline committee included: What is best initial,...
ObjectivesThe aim of this study was to determine the incidence and risk factors for community-associated Clostridium difficile infection (CDI).
The continuing rise in the incidence of Clostridium difficile infection is a cause for concern, with implications patients and health care systems. Laboratory diagnosis largely relies on rapid toxin detection kits, although assays detecting alternative targets, including glutamate dehydrogenase (GDH) genes, are now available. Six hundred routine diagnostic diarrheal samples were tested prospectively using nine commercial assays, cytotoxin assay (CYT), cytotoxigenic culture (CYTGC)...
BackgroundSlow and cumbersome laboratory diagnostics for Mycobacterium tuberculosis complex (MTBC) risk delayed treatment poor patient outcomes. Whole-genome sequencing (WGS) could potentially provide a rapid comprehensive diagnostic solution. In this prospective study, we compare real-time WGS with routine MTBC workflows.MethodsWe compared mycobacteria from all newly positive liquid cultures workflows across eight laboratories in Europe North America accuracy, processing times, cost between...