A5067383538- Clostridium difficile and Clostridium perfringens research
- Antifungal resistance and susceptibility
- COVID-19 Clinical Research Studies
- Microscopic Colitis
- Fungal Infections and Studies
- SARS-CoV-2 and COVID-19 Research
- Neutropenia and Cancer Infections
- Gut microbiota and health
- Long-Term Effects of COVID-19
- Bacterial Identification and Susceptibility Testing
- Helicobacter pylori-related gastroenterology studies
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Infectious Diseases and Mycology
- Mycobacterium research and diagnosis
- COVID-19 and healthcare impacts
- Plant Pathogens and Fungal Diseases
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Antibiotic Use and Resistance
- Tuberculosis Research and Epidemiology
- Gastrointestinal motility and disorders
- Central Venous Catheters and Hemodialysis
- COVID-19 and Mental Health
- Antibiotics Pharmacokinetics and Efficacy
University of Cologne
2016-2025
German Center for Infection Research
2016-2025
University Hospital Frankfurt
2019-2025
Goethe University Frankfurt
2016-2025
Fraunhofer Institute for Translational Medicine and Pharmacology
2024-2025
University Hospital Cologne
2016-2025
University Children's Hospital Tübingen
2024
Hospital Universitario Infanta Leonor
2024
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
2023
Heinrich Heine University Düsseldorf
2019-2023
Coronavirus disease 2019 (COVID-19) continues to cause considerable morbidity and mortality worldwide. Case reports of hospitalized patients suggest that COVID-19 prominently affects the cardiovascular system, but overall impact remains unknown.To evaluate presence myocardial injury in unselected recently recovered from illness.In this prospective observational cohort study, 100 illness were identified University Hospital Frankfurt Registry between April June 2020.Recent recovery severe...
Coronavirus in Travelers Returning from China A group of 126 German nationals was evacuated Wuhan to Frankfurt after screening for symptoms Covid-19 and undergo a 14-day quarantine a...
In 2009, the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) published first treatment guidance document for Clostridioides difficile infection (CDI). This was updated in 2014. The growing literature on CDI antimicrobial novel approaches, such as faecal microbiota transplantation (FMT) toxin-binding monoclonal antibodies, prompted ESCMID study group C. (ESGCD) to update 2014 adults.Key questions were formulated by guideline committee included: What is best initial,...
The SARS-CoV-2 pandemic has unprecedented implications for public health, social life, and the world economy. Because approved drugs vaccines are limited or not available, new options COVID-19 treatment prevention in high demand. To identify SARS-CoV-2-neutralizing antibodies, we analyzed antibody response of 12 patients from 8 to 69 days after diagnosis. By screening 4,313 SARS-CoV-2-reactive B cells, isolated 255 antibodies different time points as early Of these, 27 potently neutralized...
Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence enterococcal expansion, which was associated with graft-versus-host disease (GVHD) mortality. We found
Cardiac symptoms are increasingly recognized as late complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in previously well individuals with mild initial illness, but the underlying pathophysiology leading to long-term cardiac remains unclear. In this study, we conducted serial assessments a selected population Coronavirus Disease 2019 (COVID-19) no previous disease or notable comorbidities by measuring blood biomarkers heart injury dysfunction and...
Abstract Objectives Aspergillus fumigatus is the most common agent of invasive aspergillosis (IA). In recent years, resistance to triazoles, mainstay IA therapy, has emerged in different countries worldwide. caused by azole-resistant A. (ARAF) shows an exceedingly high mortality. this study, due ARAF isolates HSCT recipients Germany was investigated. Methods The epidemiology azole analysed two German haematology departments. Between 2012 and 2013, 762 patients received Essen (n = 388)...
The selection pressure exercised by antibiotic drugs is an important consideration for the wise stewardship of antimicrobial treatment programs. Treatment decisions are currently based on crude assumptions, and there urgent need to develop a more quantitative knowledge base that can enable predictions impact individual antibiotics human gut microbiome resistome.Using shotgun metagenomics, we quantified changes in two cohorts hematological patients receiving prophylactic antibiotics; one...
Reduced anticancer efficacy of cyclophosphamide and platinum salts has been reported in animals treated with anti-Gram-positive antibiotics. These effects were related to translocation Gram-positive bacteria during mucositis subsequent induction cytotoxic oxygen reactive species tumor invasion by pathogenic Th17 cells. To assess these hypotheses a clinical setting, we identified patients receiving for chronic lymphocytic leukemia (CLL) cisplatin relapsed lymphoma. Data originated from the...
Abstract Background Faecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening faeces donors are being embedded within regulatory frameworks described in European Union Tissue Cells Directive technical guide to quality safety tissue cells human application, published by Council. Objective Several international consensus statements concerning faecal...
Bloodstream infections (BSIs) caused by enterobacteria remain a leading cause of mortality in patients with chemotherapy-induced neutropenia. The rate and type colonization infection ESBL-producing Enterobacteriaceae (ESBL-E) their mode transmission German cancer centres is largely unknown. We performed prospective, observational study at five university-based haematology departments. Participating sites screened for intestinal ESBL-E within 72 h admission, every 10 ± 2 days thereafter...