A5083188407- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Mycobacterium research and diagnosis
- Probiotics and Fermented Foods
- Antifungal resistance and susceptibility
- Tryptophan and brain disorders
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Epigenetics and DNA Methylation
- Palliative Care and End-of-Life Issues
- T-cell and B-cell Immunology
- Biochemical Analysis and Sensing Techniques
- Infant Nutrition and Health
- Digestive system and related health
- Pancreatitis Pathology and Treatment
- Radiation Therapy and Dosimetry
- Oral health in cancer treatment
- Bacterial Identification and Susceptibility Testing
- Advances in Oncology and Radiotherapy
- Urinary Tract Infections Management
- Clinical Nutrition and Gastroenterology
- Reproductive Biology and Fertility
- Cancer Research and Treatments
Memorial Sloan Kettering Cancer Center
2019-2024
Institute Cancer De La Loire Lucien Neuwirth
2023
Hôpital Universitaire Dupuytren
2023
Centre Hospitalier Universitaire de Toulouse
2023
Centre Hospitalier Régional et Universitaire de Nancy
2023
Kettering University
2019-2022
National Zoological Park
2019
Smithsonian Conservation Biology Institute
2019
Relationships between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation have been described in single-center studies. Geographic variations the of human microbial communities differences practices across institutions raise question whether these associations are generalizable.
Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence enterococcal expansion, which was associated with graft-versus-host disease (GVHD) mortality. We found
Abstract Purpose: The gut microbiota is subject to multiple insults in allogeneic hematopoietic cell transplantation (allo-HCT) recipients. We hypothesized that preparative conditioning regimens contribute perturbation allo-HCT. Experimental Design: This was a retrospective study evaluated the relationship between exposure 1,188 allo-HCT recipients and microbiome. Stool samples collected from 20 days before up 30 after were profiled using 16S rRNA sequencing. Microbiota injury quantified by...
The impact of the gut microbiota in human health is affected by several factors including its composition, drug administrations, therapeutic interventions and underlying diseases. Unfortunately, many datasets available publicly were collected to study single variables, typically consist outpatients cross-sectional studies, have small sample numbers and/or lack metadata account for confounders. These limitations can complicate reusing data questions outside their original focus. Here, we...
Abstract Hospitalized patients receiving hematopoietic cell transplants provide a unique opportunity to study the human gut microbiome. We previously compiled large-scale longitudinal dataset of fecal microbiota and associated metadata, but we had limited that analysis taxonomic composition bacteria from 16S rRNA gene sequencing. Here augment those data with shotgun metagenomics. The compilation amounts nested subset 395 samples different studies at Memorial Sloan Kettering. Shotgun...
Ovarian tissue contains large pools of immature oocytes enclosed in primordial follicles, making it an attractive target for fertility preservation female cancer patients, livestock and wild species. Compared to cryopreservation, desiccation long-term storage samples at supra-zero temperatures (using strategies inspired from small organisms resist extreme environments) would be more cost-effective convenient. The objective the study was characterize influence microwave-assisted dehydration...
Abstract Tissue resident memory CD8 + T cells (Trm) are poised for immediate reactivation at sites of pathogen entry and provide optimal protection mucosal surfaces. The intestinal tract represents a portal many infectious agents; however, to date specific strategies enhance Trm responses this site lacking. Here, we present TMDI (Transient Microbiota Depletion-boosted Immunization), an approach that leverages antibiotic treatment temporarily restrain microbiota-mediated colonization...
Intestinal microbiota composition is implicated in several diseases; understanding the factors that influence it are key to elucidating host-commensal interactions and designing microbiome-targeted therapies. We quantified how diet influences microbiome dynamics hospitalized patients. recorded 9,419 meals consumed by 173 patients undergoing hematopoietic cell transplantation profiled 1,009 longitudinally collected stool samples from 158 of them. Caloric intake was correlated with fecal...
ABSTRACT The gut microbiota influences development and homeostasis of the mammalian immune system 1–3 , can alter cell compositions in mice 4–7 is associated with responses to immunotherapy that rely on activity peripheral cells 8–12 . Still, our understanding how modulates dynamics remains limited, particularly humans where a lack deliberate manipulations makes inference challenging. Here we study hundreds hospitalized—and closely monitored—patients receiving hematopoietic transplantation...
7015 Background: Relationships between microbiota composition and clinical outcomes following allogeneic hematopoietic cell transplantation (allo-HCT) have been described in single-center studies. Geographic variations human microbial communities differences practices across institutions raise the question of whether these associations are generalizable. We report first multi-center study intestinal allo-HCT. Methods: Intestinal 8,768 fecal samples from 1,362 allo-HCT patients at 4 centers...
Abstract Allogeneic hematopoietic cell transplantation (allo-HCT) induces profound shifts in the intestinal bacterial microbiota. The dynamics of fungi and their impact on clinical outcomes have not yet been integrated into a model microbiota function during allo-HCT. Here, we combined parallel high-throughput fungal ITS1 amplicon sequencing, 16S cultures to reveal striking trans-kingdom association with patient outcomes. We saw that overall density biodiversity were stable allo-HCT, but...
Abstract Hospitalized patients receiving hematopoietic cell transplants provide a unique opportunity to study how the human gut microbiome changes in response perturbations, and resulting feedback on its living host. We previously compiled large-scale longitudinal dataset of stool compositions from these associated metadata 1 . In that analysis was limited taxonomic composition bacterial population obtained 16S rRNA gene sequencing. Here, we augment those data with shotgun metagenomic...
<p>Supplementary Data</p>