A5071119425- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Urinary Tract Infections Management
- Probiotics and Fermented Foods
- Cancer Immunotherapy and Biomarkers
- Microscopic Colitis
- Global Cancer Incidence and Screening
- Digestive system and related health
- Pelvic floor disorders treatments
- Neutropenia and Cancer Infections
- Immune cells in cancer
- Cervical Cancer and HPV Research
- Inflammatory Bowel Disease
- Hereditary Neurological Disorders
- Infant Nutrition and Health
- Enterobacteriaceae and Cronobacter Research
- Peripheral Neuropathies and Disorders
- Helicobacter pylori-related gastroenterology studies
- Botulinum Toxin and Related Neurological Disorders
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Mycobacterium research and diagnosis
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Cancer survivorship and care
University Hospital Cologne
2018-2025
University of Cologne
2019-2025
Heinrich Heine University Düsseldorf
2025
Düsseldorf University Hospital
2025
German Center for Infection Research
2019-2025
Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence enterococcal expansion, which was associated with graft-versus-host disease (GVHD) mortality. We found
Abstract Fecal microbiota transplantation (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), typically administered as a fresh or frozen stool suspension through colonoscopy, nasojejunal tube, oral capsules. Lyophilized fecal (LFM) are an alternative to FM products. We aimed assess whether lyophilization affects bacterial viability and metabolite levels develop LFM capsules for clinical use in Germany. donations from pre-screened volunteers were aliquoted analyzed...
The gut microbiome is involved in autoimmunity. Data on its composition chronic inflammatory demyelinating polyneuropathy (CIDP), the most common autoimmune disorder of peripheral nerves, are currently lacking.In this monocentric exploratory pilot study, stool samples were prospectively collected from 16 CIDP patients (mean age 58 ± 10 years, 25% female) before and 1 week after administration intravenous immunoglobulin (IVIg). Gut microbiota analyzed via bacterial 16S rRNA gene sequencing...
The understanding of longitudinal changes in the urinary microbiota healthy women and its relation to intestinal is limited.From a cohort 15 premenopausal without known urogenital disease or current symptoms, we collected catheter urine (CU), vaginal periurethral swabs, fecal samples on four visits over six months. Additionally, ten participants provided CU midstream (MU) assess comparability. Urine was subjected expanded culture. 16S rRNA gene sequencing performed all urine, fecal, selected...
Objectives: After allogeneic hematopoietic stem cell transplantation (allo-HCT), urinary levels of 3-indoxyl sulfate (3-IS) correlate with the relative abundance bacteria from class Clostridia (RAC), and antibiotic treatment is considered major determinant this outcome. A high RAC has been associated favorable outcome after allo-HCT protection Clostridium difficile infection (CDI). We assessed correlations between alpha diversity, 3-IS in a non-allo-HCT clinical cohort treated patients to...
Objective Several recent studies have identified a potential interaction between the vaginal microbiota and gynecological cancers, but little is known about cervical its changes during cancer treatment. Therefore, aim of study was to evaluate quantitative qualitative in patients undergoing concurrent chemotherapy radiation treatment for locally advanced cancer. Methods Cervical cytobrush samples 15 chemoradiation were collected 1 day before starting external beam therapy on last fraction...
Abstract Objectives We assessed the efficacy and safety of an oral antimicrobial regimen for short- long-term intestinal eradication ESBL-producing Escherichia coli Klebsiella pneumoniae (ESBL-EC/KP) in immunocompromised patients. Methods performed a randomized (2:1), double-blind multicentre Phase II study four haematology–oncology departments. Patients colonized with ESBL-EC/KP received 7 day colistin (2 × 106 IU 4×/day), gentamicin (80 mg 4×/day) fosfomycin (three administrations 3 g...
Composition of the intestinal microbiota has been correlated to therapeutic efficacy immune checkpoint inhibitors (ICI) in various cancer entities including melanoma. Prediction outcome such therapy, however, is still unavailable. This prospective, non-interventional study was conducted order achieve an integrated assessment connection between a specific profile and antitumor response inhibitor therapy (anti-PD-1 and/or anti-CTLA-4) melanoma patients.We assessed blood stool samples 29...
Exclusive enteral nutrition (EEN) is a highly effective therapy for remission induction in pediatric Crohn's disease (CD), but relapse rates after return to regular diet are high. Autologous fecal microbiota transfer (FMT) using stool collected during EEN-induced clinical might represent novel approach maintaining the benefits of EEN.Pediatric CD patients provided material at home, which was shipped 4 °C an FMT laboratory capsule generation and extensive pathogen safety screening. The...
Abstract Background Immune recovery following allogeneic hematopoietic stem cell transplantation (allo‐HSCT) decisively influences the occurrence of opportunistic infections, one leading causes death among this group patients. Yet, today, there are no laboratory parameters mirroring immune function sufficiently. Torque teno virus (TTV) has already proven itself as a functional marker in other settings. Aims In analysis, we investigated whether monitoring TTV‐DNA load whole blood is able to...
7005 Background: Studies suggest that decreased microbial diversity due to chemotherapeutic and antibiotic exposure may be associated with acute graft vs host disease (aGvHD) mortality in patients undergoing allogeneic HSCT. In addition, disruption of the microbiome by antibiotics lead intestinal domination pro-inflammatory bacteria, resulting increased risk aGvHD. This relationship has been described settings prophylactic use, a standard care most transplant centers. Here we assessed how...