A5013347968- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Health and Medical Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical practice guidelines implementation
- Obesity, Physical Activity, Diet
- Anesthesia and Neurotoxicity Research
- Children's Physical and Motor Development
- Orthodontics and Dentofacial Orthopedics
- Spinal Fractures and Fixation Techniques
- Gallbladder and Bile Duct Disorders
- Appendicitis Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Healthcare Systems and Technology
- Esophageal and GI Pathology
- Medical and Health Sciences Research
- Innovations in Medical Education
- Cardiac and Coronary Surgery Techniques
- Cleft Lip and Palate Research
- Esophageal Cancer Research and Treatment
- Health Literacy and Information Accessibility
- Complement system in diseases
University of Cologne
2012-2022
University Hospital Cologne
2009-2022
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2011-2018
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2004-2017
Cologne Business School
2016
Goethe University Frankfurt
1984-2015
Charité - Universitätsmedizin Berlin
2007
German Sport University Cologne
2006
National Institute of Medical Statistics
2005
Philipps University of Marburg
1994
Mortality and morbidity are higher among patients with atrial fibrillation heart failure than those alone. Catheter ablation for has been proposed as a means of improving outcomes who otherwise receiving appropriate treatment.We randomly assigned symptomatic paroxysmal or persistent did not have response to antiarrhythmic drugs, had unacceptable side effects, were unwilling take these drugs undergo either catheter (179 patients) medical therapy (rate rhythm control) (184 in addition...
Objective— Lipoprotein(a)-hyperlipoproteinemia (Lp(a)-HLP) along with progressive cardiovascular disease has been approved as indication for regular lipoprotein apheresis (LA) in Germany since 2008. We aimed to study the long-term preventive effect of LA and assess hypothetical clinical correlations apolipoprotein(a) (apo(a)) by analyzing genotypes phenotypes. Approach Results— This prospective observational multicenter included 170 patients Lp(a)-HLP (48.9 years median age at diagnosis)...
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare but life-threatening condition. In 2018, the nanobody caplacizumab was approved for treatment of adults experiencing an acute episode aTTP, in conjunction with plasma exchange (PEX) and immunosuppression minimum 30 days after stopping daily PEX. We performed retrospective, observational analysis on use 60 patients from 29 medical centers Germany during disease management. Caplacizumab led to rapid normalization platelet count...
Abstract Introduction of the nanobody caplacizumab was shown to be effective in treatment acquired thrombotic thrombocytopenic purpura (aTTP) acute setting. The official recommendations include plasma exchange (PEX), immunosuppression, and use for a minimum 30 days after stopping daily PEX. This study retrospective, observational analysis 60 patients from 29 medical centers Germany. Immunosuppressive led rapid normalization ADAMTS13 activities (calculated median, 21 days). In 35 patients,...
Early cholecystectomy within 72 hours has been shown to be superior late or delayed with regard outcome and cost of treatment. Recently, immediate 24 onset symptom was proposed as standard procedure for the management fit patients presenting acute cholecystitis. We sort find out if there are any differences in surgical outcomes between managed h those 25-72 following begin A retrospective analysis performed. The undergoing laparoscopic were compared 35 symptoms matched similar baseline...
Juvenile obesity is increasing worldwide. Preventive strategies are warranted. The school-based Children's Health Interventional Trial (the CHILT Project) combines health education and physical activity for children. effect on performance was studied after four years in 12 primary schools compared with five control schools. Anthropometric data were recorded. Physical measured by a coordination test children (balancing backwards, one-legged obstacle jumping, lateral sideways movements) 6-min...
The Tokyo guidelines provide criteria for the diagnosis and classification of acute cholecystitis in three severity grades. However, no data exists on predictive value these guidelines. aim this study was to analyze accuracy as a predicting parameter patients undergoing laparoscopic cholecystectomy. A retrospective analysis charts cholecystectomy primary care hospital within five-year period performed. preoperative grades were compared with histological extent inflammation. One hundred...
Abstract Background Intrathoracic anastomotic leaks represent a major complication after Ivor Lewis esophagectomy. There are two promising endoscopic treatment strategies in the case of leaks: placement self-expanding metal stents (SEMS) or vacuum therapy (EVT). Up to date, there is no prospective data concerning optimal strategy. This protocol description for ESOLEAK trial, which first small phase 2 randomized trial evaluating quality life by either SEMS EVT. Methods will be conducted at...
Obesity in childhood, which is associated with cardiovascular risk factors such as hypertension, on the increase. Countermeasures are necessary. In this paper, we present baseline and final data from StEP TWO programme, a prospective study to prevent overweight obesity primary schools. Methods: We recorded calculated, 1689 children, anthropometric data, including analyses of bioelectric impedance, waist hip circumferences, body mass index its standard deviation, ratio hip. Blood pressure was...
Mösges R, Graute V, Christ H, Sieber H‐Jochen, Wahn U, Niggemann B. Safety of ultra‐rush titration sublingual immunotherapy in asthmatic children with tree‐pollen allergy. Pediatr Allergy Immunol 2010: 21: 1135–1138. © 2010 John Wiley & Sons A/S The recommendation to use sublingual‐swallow (SLIT) and adults allergic rhinitis has been established over the past decade. Recently, SLIT become more common, raising concerns about its safety asthma. Fifty‐four asthma adolescents aged 6–14...
Objective: AIDS-related lymphomas (ARLs) significantly contribute to mortality in HIV-infected patients. Optimal chemotherapy treatment and the use of rituximab remain controversial. The aim present cohort study was analyze outcome patients diagnosed with ARL, regard rituximab, clinical characteristics histopathological markers. Methods design: This observational uncontrolled multicenter included 163 ARL between January 2005 December 2008 Germany. Results: Patients CD20-positive had a better...
Health literacy (HL) is considered a key concept to positively address relevant decisions concerning physical and mental health. According an integrated model of European Consortium, the process access, understand, appraise apply health information at centre practising HL.In this study, we examine HL in population with early onset disorder (MD).Results are based on cross-sectional survey among people MD (n = 310) who sought help detection for Cologne, Dresden or Munich. Help-seekers filled...