A5002417517- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Esophageal and GI Pathology
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Liver physiology and pathology
- Esophageal Cancer Research and Treatment
- Diet, Metabolism, and Disease
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Diet and metabolism studies
- Organ Transplantation Techniques and Outcomes
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Screening and Detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Gallbladder and Bile Duct Disorders
- Hepatitis Viruses Studies and Epidemiology
- Pancreatic and Hepatic Oncology Research
- Chronic Lymphocytic Leukemia Research
University Hospital Cologne
2015-2024
University of Cologne
2014-2024
Poliklinik für Endokrinologie, Diabetologie und Präventivmedizin
2012-2024
Charité - Universitätsmedizin Berlin
2018-2021
University College London
2013-2021
Weatherford College
2021
University of Florida
2020
Columbus Oncology and Hematology Associates
2020
Centrum für Integrierte Onkologie
2002-2019
Constructing Excellence
2016
In patients with chronic infection hepatitis C virus (HCV) genotype 1, treatment peginterferon alfa and ribavirin for 48 weeks results in rates of sustained virologic response 40 to 50%. Telaprevir is a specific inhibitor the HCV serine protease could be value treatment.A total 334 who had 1 not been treated previously were randomly assigned receive one four treatments involving various combinations telaprevir (1250 mg on day then 750 every 8 hours), alfa-2a (180 microg weekly), (dose...
Objective The antiplatelet activity of clopidogrel is characterized by considerable interindividual differences. Variable intestinal absorption suggested to contribute the inconsistencies in response. We tested hypothesis that efflux transporter P-glycoprotein (P-gp) limits oral bioavailability and variance MDR1 gene encoding P-gp predicts variability. Methods Results P-gp-mediated transport was assessed transflux, influx, experiments use Caco-2 cells. Inhibition different modulators...
Based on positive results from small single center studies, granulocyte-colony stimulating factor (G-CSF) is being widely used for the treatment of patients with acute-on-chronic liver failure (ACLF). Herein, we aimed to evaluate safety and efficacy G-CSF in ACLF.In this multicenter, prospective, controlled, open-label phase II study, 176 ACLF (EASL-CLIF criteria) were randomized receive (5 μg/kg daily first 5 days every third day thereafter until 26) plus standard medical therapy (SMT) (n =...
To study possible extrahepatic sites for the replication of hepatitis C virus (HCV), we examined fresh and cultured peripheral blood mononuclear leukocytes (PBML), as well different subpopulations PBML HCV-infected patients, presence viral genomic antigenomic RNA. Sense antisense oligonucleotide primers derived from HCV sequences were used reverse transcription (RT) followed by an amplification with polymerase chain reaction assay (PCR). Using RT, RNA could be detected in serum, liver, total...
<h3>Objective</h3> Insulin resistance is a predictor of poor response to peginterferon/ribavirin in patients infected with the chronic hepatitis C virus (HCV). There are no data on direct-acting antivirals. This exploratory analysis assessed effect metabolic factors and insulin resistance, measured by homoeostatic model assessment (HOMA), virological telaprevir Study C208. <h3>Design</h3> Overall, 161 HCV genotype 1-infected, treatment-naïve received 12 weeks plus peginterferon/ribavirin,...
Objectives The management of upper gastrointestinal bleeding (UGIB) has seen rapid advancements with revolutionising innovations. However, insufficient data exist on the necessary number emergency endoscopies needed to achieve competency in haemostatic interventions. Design We retrospectively analysed all oesophagogastroduodenoscopies signs recent haemorrhage performed between 2015 and 2022 at our university hospital. A learning curve was created by plotting previously against treatment...
Hepatitis B virus (HBV) is an important human pathogen, which targets the liver extremely efficient, gaining access to hepatocytes by a so far unknown receptor and replicating in hepatocyte-specific fashion. Cell differentiation seems determine HBV replication. We here show that level of hepatocyte differentiation, as indicated polarization metabolic activity, closely correlated transcription RNA pregenome. Pregenome determined replication various cell lines hepatocellular origin primary...
Overconsumption of carbohydrates and lipids are well known to cause nonalcoholic fatty liver disease (NAFLD), while the role nutritional protein intake is less clear. In Western diet, meat other animal products main source, with varying concentrations specific amino acids. Whether amount or composition associated a higher risk for severity has not yet been examined. this study, we investigated associations dietary components histological activity by analyzing detailed 14‐day food records in...
Abstract Background and Aim Several studies observed alterations in the gut microbiota patients with non‐alcoholic fatty liver disease (NAFLD). However, analyzed patient populations methods strongly differ among these studies. The aim of this study was to prove reproducibility published results provide a detailed overview all findings our NAFLD cohort using next generation sequencing methods. Methods individual taxonomic composition fecal samples from 90 21 healthy controls 16S rRNA gene...
Self-expandable metal stents (SEMS) and endoscopic vacuum therapy (EVT) are options for treating leaks of the esophagus. VACStent® is a variant SEMS that aims to combine advantages EVT in one device. Due this unique construction, can build barrier leak facilitate wound healing with EVT, all while maintaining intestinal passage. We present first prospective feasibility study upper gastrointestinal tract. Between September 2019 November 2020, we performed prospective, investigator-initiated,...
The antiviral efficacy of amantadine in patients with chronic hepatitis C is controversial. In this randomized, prospective, placebo–controlled, multicenter trial, triple therapy interferon alfa (IFN–α)–2a plus ribavirin and (amantadine group) was compared combination IFN–α (control group). Four hundred previously untreated histologically proven were randomly allocated to treatment sulphate (100 mg twice daily orally) or a matched placebo together induction (1,000–1,200 mg/day for 48 weeks....
Nonalcoholic fatty liver disease (NAFLD) is a common chronic ranging from simple to steatohepatitis, fibrosis, and cirrhosis. We aimed analyze the diagnostic performance clinical utility of noninvasive tests alone or in combination for detection advanced fibrosis patients with NAFLD.Data 323 biopsy-proven NAFLD/NASH who presented Clinic Gastroenterology Hepatology, University Hospital Cologne between July 1998 November 2009, were analyzed retrospectively. Sensitivity, specificity, positive...