José Luís Calleja
A5037927976- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug-Induced Hepatotoxicity and Protection
- Diet, Metabolism, and Disease
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Alcohol Consumption and Health Effects
- Nosocomial Infections in ICU
- Gastric Cancer Management and Outcomes
- Attention Deficit Hyperactivity Disorder
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Abdominal vascular conditions and treatments
Hospital Universitario Puerta de Hierro Majadahonda
2016-2025
Universidad Autónoma de Madrid
2015-2024
Centro de Investigación Biomédica en Red
2017-2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2015-2024
Instituto de Salud Carlos III
2016-2024
Instituto de Investigación Sanitaria de Santiago
2022-2023
Virginia Commonwealth University
2019-2022
MD Anderson Cancer Center Madrid
2022
Hospital La Luz
2022
Universidad Mayor
2020-2021
Summary The disease burden of hepatitis C virus ( HCV ) is expected to increase as the infected population ages. A modelling approach was used estimate total number viremic infections, diagnosed, treated and new infections in 2013. In addition, model change progression mortality 2013–2030. Finally, expert panel consensus capture current treatment practices each country. Using today's paradigm, projected decline or remain flat all countries studied. However, same time period, individuals with...
Intestinal bacterial overgrowth and translocation, both common in cirrhosis with ascites, may lead to the activation of monocytes lymphocytes, increased levels proinflammatory cytokines, enhanced synthesis nitric oxide present cirrhosis. Bacterial endotoxin promotes lipopolysaccharide (LPS)-binding protein (LBP), forms a LPS-LBP complex that binds CD14. This study was designed evaluate LBP their correlation immune response hemodynamic status cirrhotic patients. Plasma LBP, endotoxin, soluble...
Obesity increases the risk of clinical decompensation in cirrhosis, possibly by increasing portal pressure. Whether weight reduction can be safely achieved through lifestyle (LS) changes (diet and exercise) overweight/obese patients with if loss reduces pressure this setting, is unknown. This prospective, multicentric, uncontrolled pilot study enrolled compensated hypertension (hepatic venous gradient [HVPG] ≥6 mm Hg), body mass index (BMI) ≥26 kg/m2 an intensive 16-week LS intervention...
Whether there is a change of hepatocellular carcinoma (HCC) incidence in chronic hepatitis B patients under long‐term therapy with potent nucleos(t)ide analogues currently unclear. We therefore assessed the HCC beyond year 5 entecavir/tenofovir (ETV/TDF) and tried to determine possible factors associated late occurrence. This European, 10‐center, cohort study included 1,951 adult Caucasian without at baseline who received ETV/TDF for ≥1 year. Of them, 1,205 (62%) within first years have been...
•In total, 17,374 patients with viral and non-viral hepatitis from 11 global prospective cohorts/trials were studied.•An HCC risk score (called the aMAP score, ranging 0 to 100), which involves only age, male, albumin–bilirubin platelet data, was developed validated.•The had excellent discrimination calibration in assessing 5-year irrespective of aetiology ethnicity.•Patients <50, accounting for 44% overall population, an incidence <0.2% per year. Background & AimsHepatocellular carcinoma...
Patients admitted with acute variceal bleeding (AVB) and Child-Pugh C score (CP-C) or B plus active at endoscopy (CP-B+AB) are high risk for treatment failure, rebleeding, mortality. A preemptive transjugular intrahepatic portosystemic shunt (p-TIPS) has been shown to improve survival in these patients, but its use clinical practice challenged not routinely incorporated. The present study aimed further validate the role of TIPS a large number high-risk patients. This multicenter,...
•Variceal bleeding is frequently associated with ACLF in cirrhosis.•ACLF independently rebleeding and mortality.•Patients variceal can benefit from a pre-emptive (early) TIPS. Background & AimsThe relationship between acute-on-chronic liver failure (ACLF) acute (AVB) poorly understood. Specifically, the prevalence prognosis of context AVB unclear, while role transjugular intrahepatic portosystemic shunt (TIPS) management patients has not been described to date.MethodsA multicenter,...
This study assessed the effects of glucagon-like peptide-1 (GLP-1)/glucagon receptor co-agonist efinopegdutide relative to selective GLP-1 agonist semaglutide on liver fat content (LFC) in patients with non-alcoholic fatty disease (NAFLD).This was a phase IIa, randomized, active-comparator-controlled, parallel-group, open-label study. A magnetic resonance imaging-estimated proton density fraction assessment performed determine LFC at screening and Week 24. Participants an ≥10% were...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most common chronic worldwide. It important to develop noninvasive tests assess severity and prognosis.