David Semela
A5085610901- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Hepatitis Viruses Studies and Epidemiology
- Cancer, Hypoxia, and Metabolism
- Inflammatory Bowel Disease
- Organ Transplantation Techniques and Outcomes
- Microscopic Colitis
- Phagocytosis and Immune Regulation
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Apelin-related biomedical research
- Radiomics and Machine Learning in Medical Imaging
- PI3K/AKT/mTOR signaling in cancer
- Eosinophilic Esophagitis
- Diet, Metabolism, and Disease
- Congenital Anomalies and Fetal Surgery
- Developmental Biology and Gene Regulation
Kantonsspital St. Gallen
2016-2025
University of St. Gallen
2015-2025
University of Zurich
2018-2023
Beth Israel Deaconess Medical Center
2021
Harvard University
2021
Kantonsspital Baselland
2021
University Hospital of Lausanne
2021
Goethe University Frankfurt
2020
University of Basel
2012-2020
Intercept Pharmaceuticals (United States)
2019
Summary The disease burden of hepatitis C virus ( HCV ) is expected to increase as the infected population ages. A modelling approach was used estimate total number viremic infections, diagnosed, treated and new infections in 2013. In addition, model change progression mortality 2013–2030. Finally, expert panel consensus capture current treatment practices each country. Using today's paradigm, projected decline or remain flat all countries studied. However, same time period, individuals with...
•Patients with acutely decompensated cirrhosis without ACLF develop 3 different clinical courses.•Patients pre-ACLF within 90 days and have high systemic inflammation mortality.•Patients unstable suffer from complications of severe portal hypertension.•Patients stable less frequent lower 1-year mortality risk. Background & AimsAcute decompensation (AD) is defined as the acute development ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or any combination thereof,...
Novel direct antiviral agents (DAA) targeting hepatitis C virus (HCV) have revolutionized the treatment of chronic infection (CHC). Rates sustained virological response (SVR) to drastically improved since introduction DAA. Transient Elastography (TE) is an ultrasound based, non-invasive technique assess liver stiffness (LS). We examined changes in TE values and fibrosis scores FIB-4 APRI after DAA CHC.549 patients who received a based for CHC were screened 392 included. recorded prior...
Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading both these AD phenotypes. The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients (No = 1,071; 202). Medical history, clinical data laboratory were collected at enrolment during 90-day...
Direct-acting oral anticoagulants (DOACs) are used in patients with splanchnic vein thrombosis (SVT) and cirrhosis, but evidence for safety efficacy this setting is limited. Our aim was to identify indications reasons starting or switching DOACs report adverse effects, complications short-term outcome.Data collection including demographic information, laboratory values, treatment through the Vascular Liver Disease Interest Group Consortium.Forty-five centres (90%) of consortium completed...
Summary The number of hepatitis C virus ( HCV ) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used forecast two treatment scenarios: (i) the impact increased efficacy keeping treated patients constant and (ii) increasing rate. This analysis suggests that successful diagnosis a small proportion can contribute significantly reduction burden in countries studied. largest ‐related morbidity mortality occurs when combined higher...
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCC) are the most common liver tumors a leading cause for cancer-related death in men. Notch2 regulates cellular differentiation developing adult liver. Although aberrant Notch signaling is implicated various cancers, it still unclear whether proliferation carcinogenesis thereby contributes to HCC CCC formation. Here, we investigated oncogenic potential of constitutive We show that liver-specific expression intracellular domain (N2ICD)...
Importance Surgical site infections (SSIs) are one of the most common health care–associated infections. can have harmful effects in liver transplant (LT) recipients. Objective To assess incidence SSI after LT and identify risk factors associated with SSIs whether death graft loss. Design, Setting, Participants A multicenter cohort study encompassing data on performed at all Swiss centers between May 1, 2008, September 30, 2020, was conducted. Data analyses were 2023. Exposure Liver...
Abstract The underlying mechanisms of reactive macrophage activation syndromes (rMAS) are not understood in detail, and there is no specific treatment. This observational study was prompted by intravenous immunoglobulin (IVIG), dramatically halting two distinct rMAS episodes the same patient. We evaluated potential benefits IVIG administration treating fulminant usefulness monitoring serum ferritin levels as an indication for emergency treatment with IVIG. Ten females 10 males experiencing...
Endothelial cell-based angiogenesis requires activation of survival signals that generate resistance to external apoptotic stimuli, such as tumor necrosis factor-alpha (TNF-alpha), during pathobiologic settings. Mechanisms by which this is achieved are not fully defined. Here, we use a model in the multifunctional cytokine nitric oxide counterbalances TNF-alpha-induced apoptosis, define role for membrane trafficking process endothelial cell signaling. By perturbing dynamin GTPase function,...
Hepatic stellate cells (HSCs) contribute to portal hypertension through multiple mechanisms that include collagen deposition, vasoconstriction, and regulation of sinusoidal structure. Under normal physiologic conditions, endothelial nitric oxide (NO) synthase–derived NO exerts paracrine effects on HSCs; however, in cirrhosis, generation is impaired association with concomitant HSC activation changes structure, events significantly the development hypertension. These concepts, combination...
<h3>Objective</h3> The natural course of chronic hepatitis C varies widely. To improve the profiling patients at risk developing advanced liver disease, we assessed relative contribution factors for fibrosis progression in C. <h3>Design</h3> We analysed 1461 with an estimated date infection and least one biopsy. Risk accelerated rate (FPR), defined as ≥0.13 Metavir units per year, were identified by logistic regression. Examined included age infection, sex, route HCV genotype, body mass...