Linard Hoessly
A5007601283- Gene Regulatory Network Analysis
- Computational Drug Discovery Methods
- Origins and Evolution of Life
- SARS-CoV-2 and COVID-19 Research
- Renal Transplantation Outcomes and Treatments
- Advanced Combinatorial Mathematics
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Herpesvirus Infections and Treatments
- Philosophy and History of Science
- stochastic dynamics and bifurcation
- Genomics and Phylogenetic Studies
- Organ Transplantation Techniques and Outcomes
- Evolution and Paleontology Studies
- Dialysis and Renal Disease Management
- Biomedical Text Mining and Ontologies
- Formal Methods in Verification
- Complex Network Analysis Techniques
- Simulation Techniques and Applications
- Microbial Metabolic Engineering and Bioproduction
- Liver Disease and Transplantation
- Point processes and geometric inequalities
- Mathematical Dynamics and Fractals
- Surgical site infection prevention
- Salivary Gland Disorders and Functions
Swiss HIV Cohort Study
2023-2025
University Hospital of Basel
2023-2025
Hospital Base
2024
University of Copenhagen
2019-2022
University of Fribourg
2016-2020
Importance Surgical site infections (SSIs) are one of the most common health care–associated infections. can have harmful effects in liver transplant (LT) recipients. Objective To assess incidence SSI after LT and identify risk factors associated with SSIs whether death graft loss. Design, Setting, Participants A multicenter cohort study encompassing data on performed at all Swiss centers between May 1, 2008, September 30, 2020, was conducted. Data analyses were 2023. Exposure Liver...
Abstract Background The use of assays detecting cytomegalovirus (CMV)–specific T cell–mediated immunity may individualize the duration antiviral prophylaxis after transplantation. Methods In this randomized trial, kidney and liver transplant recipients from 6 centers in Switzerland were enrolled if they CMV-seronegative with seropositive donors or CMV-seropositive receiving antithymocyte globulins. Patients to a based on immune monitoring (intervention) fixed (control). control group planned...
There are limited contemporary data on the epidemiology and outcomes of bacteremia in solid organ transplant recipients (SOTr).Using Swiss Transplant Cohort Study registry from 2008 to 2019, we performed a retrospective nested multicenter cohort study describe SOTr during first year post-transplant.Of 4383 patients, 415 (9.5%) with 557 cases due 627 pathogens were identified. One-year incidence was 9.5%, 12.8%, 11.4%, 9.8%, 8.3%, 5.9% for all, heart, liver, lung, kidney, kidney-pancreas...
We investigate a broad family of stochastically modeled reaction networks by looking at their stationary distributions. Most known results on distributions assume weak reversibility and zero deficiency. first explicitly give product-form for class mostly non-weakly-reversible autocatalytic arbitrary provide examples interest in statistical mechanics (inclusion process), life sciences, robotics (collective decision making ant robot swarms). The nature the distribution then enables study...
Abstract Background Many potential prognostic factors for predicting kidney transplantation outcomes have been identified. However, in Switzerland, no widely accepted model or risk score is being routinely used clinical practice yet. We aim to develop three prediction models the prognosis of graft survival, quality life, and function following Switzerland. Methods The (KIDMO) are developed with data from a national multi-center cohort study (Swiss Transplant Cohort Study; STCS) Swiss Organ...
Introduction: Approximately two-thirds of patients with Obsessive-Compulsive Disorder (OCD) exhibit inadequate responses to current standard therapies. A previous meta-analysis has shown the potential benefit repetitive transcranial magnetic stimulation (rTMS) dorsolateral prefrontal cortex (dlPFC) area in OCD. However, analysis also included who had not previously failed first-line treatments. This mini-review aims explore therapeutic effects rTMS applied dlPFC treatment-resistant Methods:...
Abstract Background Clinically significant cytomegalovirus infection (csCMVi) is the most frequent viral in kidney transplant recipients (KTR). A daily dose of 900 mg valganciclovir (VGC) as primary antiviral prophylaxis (PAP) frequently administered to KTR at risk for csCMVi, including CMV donor (D)+/recipient (R)− and R+ patients after induction immunosuppression with thymoglobulin (R+/TG) until 6- 3-months post-transplant, respectively. Dose adjustments VGC are recommended based on renal...
The COVID-19 pandemic has had worldwide devastating effects on human lives, highlighting the need for tools to predict its development. Dynamics of such public-health threats can often be efficiently analysed through simple models that help make quantitative timely policy decisions. We benchmark a minimal version Susceptible-Infected-Removed model infectious diseases (SIR) coupled with least-squares Statistical Heuristic Regression (SHR) based lognormal distribution. derived three free...
We study realization spaces of matroids over hyperfields (in the sense Baker and Bowler). More precisely, given a matroid M hyperfield H we determine space all H-matroids M. This can be seen as stratum Grassmannians in Anderson Davis. give different descriptions these (e.g., terms Tutte groups or projective classes), allowing for explicit computations. When at hand is topological, have natural topology. In this case, our models carry correct homeomorphism type. As applications methods obtain...
We study stationary distributions in the context of stochastic reaction networks. In particular, we are interested complex balanced networks and reduction such by assuming a set species (called non-interacting species) degraded fast (and therefore essentially absent network), implying some rates large compared to others. Technically, assume these scaled common parameter $N$ let $N\to\infty$. The limiting distribution as $N\to\infty$ is reduced network obtained algebraic elimination species....
Bayesian networks are widely utilised in various fields, offering elegant representations of factorisations and causal relationships. We use surjective functions to reduce the dimensionality by combining states study preservation their factorisation structure. introduce define corresponding notions, analyse properties, provide examples highly symmetric special cases, enhancing understanding fundamental properties such reductions for networks. also discuss connection between this homogeneous...
Valganciclovir (VGC) is administered as prophylaxis to kidney transplant recipients (KTR) CMV donor (D)+/recipient (R)- and R+ after thymoglobulin-induction (R+/TG). Although VGC dose adjustments based on renal function are recommended, there paucity of real-life data dosing associations with clinical outcomes. This a retrospective Swiss Transplant Cohort Study-embedded observational study, including all adult D+/R- R+/TG KTR between 2010 2020, who received VGC. The primary objective was...
While SARS-CoV-2 infection has direct obvious consequences on patients undergoing dialysis, the COVID-19 pandemic also had an indirect impact health systems. Therefore, we aimed to determine whether era itself was associated with adverse in Swiss dialysis population as compared pre-COVID-19 era, while accounting for of infection.
Most of Switzerland's population and employment opportunities are concentrated in urban areas. Although kidney transplantation (KT) is the preferred therapy for eligible candidates, individuals rural areas face challenges accessing specialized medical services due to longer travel distances. Limited understanding exists regarding patients' perspectives on returning work after KT whether this correlates with their urbanization status, potentially influencing outcomes. Retrospective,...
In 2017, Hughes claimed an equivalence between Tjurs $R^2$ coefficient of discrimination and Youden index for assessing diagnostic test performance on $2\times 2$ contingency tables. We prove impossibility result when averaging over binary outcomes (0s 1s) under any continuous real-valued scoring rule. Our findings clarify the limitations such a possible highlights distinct roles these metrics play in assessment.
Exact results for product-form stationary distributions of Markov chains are interest in different fields. In stochastic reaction networks (CRNs), mostly known special cases where they product-form. However, there is no full characterization the classes whose have We develop an algebraic approach to framework CRNs. Under certain hypotheses on linearity and decomposition state space conservative CRNs, this gives sufficient necessary conditions distributions. Correspondingly, we obtain a...
Abstract We answer two questions raised by Bryant, Francis, and Steel in their work on consensus methods phylogenetics. Consensus apply to every practical instance where it is desired aggregate a set of given phylogenetic trees (say, gene evolution trees) into resulting, “consensus” tree species tree). Various stability criteria have been explored this context, seeking model desirable consistency properties as the experimental data are updated (e.g., more taxa, or trees, mapped). However,...
Abstract We examine reaction networks (CRNs) through their associated continuous-time Markov processes. Studying the dynamics of such is in general hard, both analytically and by simulation. In particular, stationary distributions stochastic are only known some cases. analyze class properties underlying chain CRNs under operation join conditions that form a CRN derived from parts decomposed CRNs. The can be easily checked examples allow recursive application. theory developed enables...